Establishment of Specific Pathogen Free Rhesus Macaques Colonies (U42)

无特定病原体恒河猴群体（U42）的建立

• 批准号: 8601761
• 负责人: Kerry L. Taylor
• 金额: $ 35.43万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8601761
• 关键词: AIDS Vaccines; Acquired Immunodeficiency Syndrome; Address; Adult; Affect; Animals; Antiviral Agents; Bioinformatics; Biological Assay; Biomedical Research; Breeding; Cause of Death; Cercopithecine Herpesvirus 1; Disease; Employment; Ensure; Female; Funding; Future; Genetic; Genetic Variation; Genotype; Grant; HIV; HIV therapy; HIV vaccine; HIV-1; Health; Housing; Human; Immune system; Infection; Infectious Agent; Label; Life; Macaca; Macaca mulatta; Major Histocompatibility Complex; Modeling; National Center for Research Resources; Oregon; Pathogenesis; Population; Primate Lentiviruses; Primates; Principal Investigator; Production; Protein Microchips; Proteins; Public Health; Reporting; Request for Applications; Research; Research Infrastructure; Resource Informatics; Resources; Retroviridae; SIV; Solutions; Specific Pathogen Frees; T-Cell Leukemia; Target Populations; Technology; Testing; Time; United States Public Health Service; Vaccine Research; Vaccines; Viral; Virus; aged; animal model development; base; cost; data integration; design; genetic profiling; germ free condition; health organization; innovation; killings; leukemia virus; next generation; nonhuman primate; novel; offspring; pandemic disease; pathogen; programs; public health relevance; screening; simian human immunodeficiency virus; tool; tv watching; vaccine development; vaccine efficacy

DESCRIPTION (provided by applicant): A safe and effective vaccine remains the best hope of controlling the human immunodeficiency virus (HIV) pandemic. Because of the similarity of the immune system of the Indian-origin rhesus macaques and humans, vaccine development is heavily dependent on the SIV and SHIV macaque models. The need for Indian rhesus macaques for AIDS-related research continues to exceed availability. Efficient domestic breeding programs managed to produce well characterized animals that enhance their use in biomedical research and offer the best long term solution for the current shortage of Indian-origin rhesus macaques for AIDS vaccine and pathogenesis studies and to insure future availability. The purposes of this proposal are to continue to support and characterize the specific pathogen-free Indian rhesus AIDS Research Colony resource that was established in the past ten-year grant period.

描述（由申请人提供）：安全有效的疫苗仍然是控制人类免疫缺陷病毒（HIV）大流行的最大希望。由于印度恒河猴和人类的免疫系统相似，疫苗的开发在很大程度上依赖于 SIV 和 SHIV 猕猴模型。艾滋病相关研究对印度恒河猴的需求继续超出其供应量。高效的国内育种计划设法培育出特征良好的动物，增强其在生物医学研究中的应用，并为目前用于艾滋病疫苗和发病机制研究的印度恒河猴短缺问题提供最佳的长期解决方案，并确保未来的可用性。该提案的目的是继续支持和描述在过去十年资助期内建立的特定无病原体印度恒河猴艾滋病研究群体资源。