SACCADE STUDIES

扫视研究

• 批准号: 8172741
• 负责人: Chris R. S. Kaneko
• 金额: $ 15.51万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172741
• 关键词: Attention; Biological Models; Brain; Cell Nucleus; Cerebellar vermis structure; Complex; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Eye; Eye Movements; Face; Feedback; Foundations; Funding; Generations; Goals; Grant; Head; Institution; Methods; Modeling; Motor; Motor output; Movement; Nervous System Physiology; Neuraxis; Neurologic; Nucleus fastigii; Output; Physiological; Process; Production; Research; Research Personnel; Resources; Saccades; Source; System; Testing; United States National Institutes of Health; Visual; Work; abstracting; base; improved; information processing; oculomotor; research study; sensorimotor system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ultimate goal of our work is to understand how the brain functions. Because of the immensity of such an undertaking, it is only possible to study a small portion of brain function. We have chosen to study the output (motor) portion of brain function and we use the oculomotor system as our model system. Specifically, we study those fast movements known as saccadic eye movements. We continue our studies of mechanisms of saccade generation and have recently focused on the function of the caudal Fastigial nucleus (cFN), which is the output nucleus of the midline cerebellar vermis. Our studies consist of 3 related experiments to test what the function of the cFN is during the production of normal saccades. Specifically, we will use anatomical and physiological methods to test two hypotheses of cFN function; that of a feedback comparator that controls saccade amplitude versus an end-point controller that adjusts saccade amplitude in the face of unforeseen perturbations. Our anticipated results will change fundamentally, the way that we think saccades are produced. Not only will they improve our understanding of oculomotor processes but they may provide a new model for cerebellar function. If successful, the experiments will not only advance our understanding of how the brain processes information in order to formulate actions based on that information, but they are also basic to the differential neurological diagnosis based on eye-movement signs now commonly used clinically. Our results also provide a foundation for studies of more complex aspects of central nervous system function such as interactions between motor systems (e.g., eye and head during orientation) or sensory and motor systems (e.g., the visual and oculomotor systems) and more abstract functions such as attention.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们工作的最终目标是了解大脑的功能。由于这种事业的巨大，只能研究一小部分脑功能。我们选择研究大脑功能的输出（运动）部分，并将眼动系统作为模型系统。 具体而言，我们研究了那些称为saccadic眼动的快速运动。 我们继续研究扫视生成的机制，最近专注于尾尾核（CFN）的功能，后者是中线小脑vermis的输出核。我们的研究包括3个相关实验，以测试正常扫视过程中CFN的功能。具体而言，我们将使用解剖学和生理方法来检验CFN功能的两个假设。反馈比较器控制扫视幅度与终点控制器的反馈比较器的那些是在面对不可预见的扰动时调整扫视幅度的。我们预期的结果将从根本上发生变化，这是我们认为扫视的方式。它们不仅会提高我们对眼动过程的理解，而且还可以为小脑功能提供新的模型。如果成功的话，实验不仅会提高我们对大脑如何处理信息以基于该信息制定动作的理解，而且它们也是基于目前通常在临床上常用的眼动迹象的差异神经诊断的基础。我们的结果还为研究中枢神经系统功能的更复杂方面的研究提供了基础，例如运动系统（例如，在方向上的眼睛和头部）之间的相互作用，或感觉和运动系统（例如，视觉和眼动物系统）以及更多的抽象功能，例如注意力。