SACCADIC EYE MOVEMENT STUDIES

眼球扫视运动研究

• 批准号: 7349357
• 负责人: Chris R. S. Kaneko
• 金额: $ 13.2万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349357
• 关键词: SACCADIC; EYE; MOVEMENT; STUDIES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of our work is to understand how the brain functions. To do this, we study the output (motor) portions, using the oculomotor system as a model, specifically those fast movements known as saccadic eye movements. We continue our studies of brainstem mechanisms of saccade generation and have recently focused on the dynamics of the eye and the function of the nucleus reticularis tegmenti pontis (nrtp). Our study on eye mechanics (1) documented the dynamics of eye detailing important new constraints on any hypothesis of how eye movements are controlled by the brain. Our study of the nrtp (2) showed that about half the saccade-related neurons located therein may contribute to adaptive plasticity of the saccade system. Because the major input to nrtp comes from the superior colliculus, we have begun to study (4) the role of that structure in adaptive plasticity as well. My investigation of the long-lead burst neurons of the rostral pons (3) identified neurons that may act as a trigger for saccades and disproved several other previously hypothesized functions for these neurons. We continue to investigate the functions of the structures involved in saccade production and are beginning to study (5) the role of the midline cerebellum in those processes. These results not only advance our understanding of how the brain processes information in order to formulate actions based on that information, but they are also basic to the differential neurological diagnosis based on eye-movement signs now commonly used clinically as well as to our understanding of oculomotor processes. They also provide a foundation for studies of more complex aspects of central nervous system function such as interactions between motor systems (e.g., eye and head during orientation) or sensory and motor systems (e.g., the visual and oculomotor systems) and more abstract functions such as attention.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。我们工作的目的是了解大脑的功能。为此，我们使用眼动系统作为模型研究了输出（运动）部分，特别是那些称为saccadic眼动的快速运动。我们继续研究扫视生成的脑干机制，最近专注于眼睛的动力学和网细胞核的功能。我们对眼睛力学的研究（1）记录了眼睛的动力学，详细介绍了有关大脑如何控制眼动的任何假设的重要新约束。我们对NRTP（2）的研究表明，位于扫视相关的神经元的一半可能有助于扫视系统的自适应可塑性。由于NRTP的主要输入来自上丘，我们已经开始研究（4）该结构在自适应可塑性中的作用。我对Rostral PON的长长爆发神经元（3）的研究确定了神经元，这些神经元可能充当扫视的触发，并反驳了这些神经元的其他几个先前假设的功能。我们继续研究扫视生产中涉及的结构的功能，并开始研究（5）中线小脑在这些过程中的作用。这些结果不仅可以提高我们对大脑如何根据该信息制定动作的信息的理解，而且它们也是基于现在通常在临床上使用的眼动迹象以及我们对眼球运动过程的理解的差异神经诊断的基础。它们还为研究中枢神经系统功能的更复杂方面的研究提供了基础，例如运动系统（例如，在方向时的眼睛和头部）之间的相互作用，感觉和运动系统（例如，视觉和动眼动物系统）以及更多的抽象功能，例如注意力。