Biostatistics and Data Management Core

生物统计和数据管理核心

• 批准号: 10665902
• 负责人: Jiangang Liao
• 金额: $ 36.86万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665902
• 关键词: Accreditation; Adopted; Bioinformatics; Biological Markers; Biometry; Biostatistics Core; Characteristics; Clinical; Clinical Sciences; Clinical Trials; Collaborations; Communication; Communities; Computer software; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Reporting; Database Management Systems; Databases; Enrollment; Ensure; Environment; Experimental Designs; Funding; Future; Goals; Health; Health Sciences; Human; Human Resources; Individual; Infrastructure; Institution; Instruction; Laboratories; Manuscripts; Measurement; Methodology; Monitor; Monitoring Clinical Trials; Pilot Projects; Policies; Preparation; Progress Reports; Public Health; Publications; Reporting; Reproducibility; Research; Research Institute; Research Personnel; Research Project Grants; Resources; Running; Safety; Science; Security; Services; Statistical Data Interpretation; Statistical Methods; System; Techniques; Technology; Testing; Tobacco; Toxic effect; Training; Training Programs; United States National Institutes of Health; Update; Walking; Work; addiction; base; career; career development; clinical translation; complex data; course development; data integrity; data management; data sharing; database design; design; electronic data; experience; improved; innovation; instructor; lectures; meetings; member; operation; population based; skills; student mentoring; symposium; tobacco products; tobacco regulation; web app

PROJECT SUMMARY / ABSTRACT: Biostatistics and Data Management Core The Biostatistics and Data Management Core will provide support for the three Main Projects, Pilot Projects and trainees. The Core has a team of experienced biostatisticians and other quantitative experts with a wide diversity of skills, including innovative statistical analysis, REDCAP database design and management, clinical trials monitoring and reporting and bioinformatics. The Core has developed a large infrastructure in the previous funding period (Penn State TCORS; P50 DA036107) and has worked closely with each of the project leaders. The Core will be an integral part of the whole Project. Its members will participate in regular project meetings and will provide timely and high-quality service by welcoming walk-in discussion and by quick turnaround in data analysis (1-3 workdays). The Core Director will also present progress reports at each of the External Advisory Board meetings. The core will take steps to enhance the rigor and reproducibility of the research, using the REDCAP database management system to ensure data accuracy, providing weekly reports of study progress, and ensuring that have a set of clearly defined scientific questions before data collection and analysis begins, using best-practice and transparent statistical methods. Overall, the three Main Projects, Pilot Projects and Career Development activities test hypotheses about tobacco products and their impact on addiction, toxicity and health effects. The biostatistics Core staff have become well versed in tobacco research, have co-authored TCORS publications, and provide advice on statistical approaches as they relate to tobacco-specific issues. They will participate in the Career Enhancement Training Program, including mentoring of students and serving as class instructors in the TCORS-accredited courses. Additionally, they will be statistical consultants to the pilot projects, including providing assistance with power calculations, design issues and statistical analyses of results.

项目摘要/摘要：生物统计学和数据管理核心 生物统计和数据管理核心将为三个主要项目、试点项目和 实习生。核心拥有一支由经验丰富的生物统计学家和其他多元化的定量专家组成的团队 技能，包括创新统计分析、REDCAP 数据库设计和管理、临床试验 监测和报告以及生物信息学。核心在过去开发了大型基础设施 资助期间（宾夕法尼亚州立大学 TCORS；P50 DA036107），并与每个项目负责人密切合作。 核心将是整个项目的一个组成部分。其成员将参加定期项目会议 并将通过欢迎直接讨论和快速的数据周转来提供及时和高质量的服务 分析（1-3 个工作日）。核心董事还将在每次外部咨询会上提交进度报告 董事会会议。核心将采取措施提高研究的严谨性和可重复性，利用 REDCAP数据库管理系统确保数据准确性，每周提供研究进展报告， 并确保在数据收集和分析开始之前有一套明确定义的科学问题， 使用最佳实践和透明的统计方法。总体而言，三个主要项目、试点项目和 职业发展活动测试有关烟草产品的假设及其对成瘾、毒性的影响 和健康影响。生物统计学核心人员精通烟草研究，共同撰写了 TCORS 出版物，并提供与烟草特定问题相关的统计方法的建议。 他们将参加职业提升培训计划，包括指导学生和服务 作为 TCORS 认证课程的班级讲师。此外，他们还将担任试点的统计顾问 项目，包括提供功率计算、设计问题和结果统计分析方面的帮助。