DEVELOPMENT OF PORTABLE COMPUTER PROGRAMS FOR HUMAN GENETIC ANALYSIS

用于人类遗传分析的便携式计算机程序的开发

• 批准号: 8171710
• 负责人: Robert C. Elston
• 金额: $ 50.41万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171710
• 关键词: Address; Code; Collaborations; Complex; Computer Retrieval of Information on Scientific Projects Database; Computer software; Computers; Data; Data Set; Databases; Development; Family; Funding; Goals; Grant; Human; Human Genetics; Institution; Internet; Java; Joints; Learning; Licensing; Linux; Modeling; Operating System; Phenotype; Relative (related person); Research; Research Personnel; Resources; Running; Source; Source Code; Time; United States National Institutes of Health; base; computer program; design; genetic analysis; genetic epidemiology; genetic linkage analysis; graphical user interface; open source; programs; segregation; simulation; syntax; tool; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The S.A.G.E. (Statistical Analysis for Genetic Epidemiology) computer program package provides researchers with the tools necessary for various types of statistical genetic analysis of human family data. Prior to the funding of this resource, few such computer programs were available, and those in existence were usually poorly documented and not easily transportable from one type of computer to another. This subproject has addressed these problems by developing computer programs for genetic analysis that are well documented and portable between different computers and operating systems. S.A.G.E. version 6.0 was released in January, 2009 and new releases of the software are posted, on average, twice per year. The program is constructed from compiled C++ code and runs on Windows, Unix/Linux, Solaris and MacOS platforms. The software includes a Java-based graphical user interface (GUI) designed to eliminate the need for new users to learn the complex syntax for program configuration. At the same time, advanced users may still create and analyze very sophisticated models using either the GUI or the more traditional command line version of the software. New features in version 6.0 include a completely new program, RELPAL, designed to perform model-free linkage analysis of a multivariate trait using all relative pairs. Significant improvements were made to the ASSOC program to make it better suited for analyzing large SNP data sets. Lastly, the S.A.G.E. source code was made available under the Berkley open source license. The next major release (version 6.1) is expected to include a new utility for managing high-throughput marker phenotypes, joint segregation and linkage analyses, and an efficient, generalized simulation program. A major redesign of S.A.G.E. is currently under consideration with the goal of making the software better integrated with the internet, and supporting collaboration between investigators using a common database.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 S.A.G.E. （遗传流行病学的统计分析）计算机计划软件包为研究人员提供了各种类型的人类家庭数据统计遗传分析所需的工具。 在资助此资源之前，很少有此类计算机程序可用，并且存在的计算机程序通常记录得很差，并且不容易从一种类型的计算机运输到另一种计算机。 该子项目通过开发用于遗传分析的计算机程序来解决这些问题，这些程序在不同的计算机和操作系统之间已有文献记载和便携式。 圣人。 6.0版于2009年1月发布，该软件的新版本平均每年两次发布。 该程序由编译的C ++代码构建，并在Windows，Unix/Linux，Solaris和MacOS平台上运行。 该软件包括基于Java的图形用户界面（GUI），旨在消除新用户学习用于程序配置的复杂语法的需求。 同时，高级用户仍然可以使用GUI或更传统的命令行版本创建和分析非常复杂的模型。 6.0版中的新功能包括一个全新的程序Relpal，旨在使用所有相对对对多元特征进行无模型的链接分析。 对协会计划进行了重大改进，以使其更适合分析大型SNP数据集。 最后，S.A.G.E.根据Berkley开源许可证提供了源代码。 预计下一个主要版本（6.1版）将包括一个新的实用程序，用于管理高通量标记表型，关节隔离和链接分析以及有效的，广义的仿真程序。 S.A.G.E.的重大重新设计目前正在考虑的目的是使软件更好地与Internet集成，并使用常见数据库支持调查人员之间的协作。