GENETIC ANALYSIS WORKSHOP 16

遗传分析研讨会 16

• 批准号: 8171715
• 负责人: Robert C. Elston
• 金额: $ 3.95万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171715
• 关键词: Complex; Computer Retrieval of Information on Scientific Projects Database; Data; Data Set; Educational workshop; Environmental Risk Factor; Epidemiologist; Framingham Heart Study; Funding; Genetic; Genetic Determinism; Genotype; Grant; Individual; Institution; Lipids; Methods; Modeling; Multicenter Studies; Myocardial Infarction; Paper; Participant; Phenotype; Publishing; Research; Research Personnel; Resources; Rheumatoid Arthritis; Sampling; Serum; Simulate; Single Nucleotide Polymorphism; Source; United States National Institutes of Health; Work; base; case control; genetic analysis; genetic pedigree

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Every two years a Genetic Analysis Workship (GAW) is held, at which internationally reputed genetic epidemiologists analyze real and simulated data sets in order to demonstrate new methods of genetic analysis. For the 16th GAW, for which analytical work was begun in 2008, two real and one simulated data set were available. The first real data set comprised case-control data, including phenotypes and genotypes for nearly 550,000 single-nucleotide polymorphisms (SNPs) on 2,062 participants, from a multicenter study of the genetics of rheumatoid arthritis. The second real data set comprised 765 pedigrees from the Framingham Heart Study, including dozens of phenotypes from nine examination period and genotypes for 550,000 SNPs on a total of 6,752 typed individuals. The simulated data set consisted of 100 replicate samples based on 6,476 of the Framingham study participants included in the second real data set. Phenotypes, including myocardial infarction and serum lipid levels, were simulated using a complex model incorporating many interacting genetic determinants and environmental factors, providing the genetic epidemiologist with a rich variety of analytical possibilities. Papers from this workshop are now published.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 每两年一次进行遗传分析工作（GAW），在该工作中，国际知名的遗传流行病学家分析了真实和模拟数据集，以证明遗传分析的新方法。 对于2008年开始分析工作的第16个GAW，可以使用两个真实和一个模拟数据集。 第一个真实数据集包含病例对照数据，包括来自2,062名参与者的近550,000个单核苷酸多态性（SNP）的表型和基因型，以及类风湿关节炎遗传学的多中心研究。 第二个真实数据集包括来自弗雷明汉心脏研究的765个血统，其中包括9个检查期的数十种表型和550,000个SNP的基因型，总共有6,752个类型的个体。 模拟数据集由100个重复样本组成，基于第二个真实数据集中包含的6,476名弗雷明汉研究参与者。 使用融合许多相互作用的遗传决定因素和环境因素的复杂模型模拟了包括心肌梗塞和血清脂质水平在内的表型，从而为遗传流行病学家提供了各种各样的分析可能性。 该研讨会的论文现已发表。