GENETIC ANALYSIS WORKSHOP 16

遗传分析研讨会 16

• 批准号: 8171715
• 负责人: Robert C. Elston
• 金额: $ 3.95万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171715
• 关键词: Complex; Computer Retrieval of Information on Scientific Projects Database; Data; Data Set; Educational workshop; Environmental Risk Factor; Epidemiologist; Framingham Heart Study; Funding; Genetic; Genetic Determinism; Genotype; Grant; Individual; Institution; Lipids; Methods; Modeling; Multicenter Studies; Myocardial Infarction; Paper; Participant; Phenotype; Publishing; Research; Research Personnel; Resources; Rheumatoid Arthritis; Sampling; Serum; Simulate; Single Nucleotide Polymorphism; Source; United States National Institutes of Health; Work; base; case control; genetic analysis; genetic pedigree

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Every two years a Genetic Analysis Workship (GAW) is held, at which internationally reputed genetic epidemiologists analyze real and simulated data sets in order to demonstrate new methods of genetic analysis. For the 16th GAW, for which analytical work was begun in 2008, two real and one simulated data set were available. The first real data set comprised case-control data, including phenotypes and genotypes for nearly 550,000 single-nucleotide polymorphisms (SNPs) on 2,062 participants, from a multicenter study of the genetics of rheumatoid arthritis. The second real data set comprised 765 pedigrees from the Framingham Heart Study, including dozens of phenotypes from nine examination period and genotypes for 550,000 SNPs on a total of 6,752 typed individuals. The simulated data set consisted of 100 replicate samples based on 6,476 of the Framingham study participants included in the second real data set. Phenotypes, including myocardial infarction and serum lipid levels, were simulated using a complex model incorporating many interacting genetic determinants and environmental factors, providing the genetic epidemiologist with a rich variety of analytical possibilities. Papers from this workshop are now published.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 每两年举办一次遗传分析研讨会（GAW），国际知名的遗传流行病学家分析真实和模拟的数据集，以展示遗传分析的新方法。 第 16 届 GAW 的分析工作于 2008 年开始，提供了两个真实数据集和一个模拟数据集。 第一个真实数据集包含病例对照数据，包括来自类风湿性关节炎遗传学多中心研究的 2,062 名参与者的近 550,000 个单核苷酸多态性 (SNP) 的表型和基因型。 第二个真实数据集包含来自 Framingham 心脏研究的 765 个家系，包括来自 9 个检查周期的数十个表型以及总共 6,752 个分型个体的 550,000 个 SNP 的基因型。 模拟数据集由 100 个重复样本组成，这些样本基于第二个真实数据集中包含的 6,476 名 Framingham 研究参与者。 使用包含许多相互作用的遗传决定因素和环境因素的复杂模型模拟表型，包括心肌梗死和血清脂质水平，为遗传流行病学家提供了丰富的分析可能性。 本次研讨会的论文现已出版。