Human Genetic Analysis Resource

人类遗传分析资源

• 批准号: 7897983
• 负责人: Robert C. Elston
• 金额: $ 92.26万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-14 至 2012-06-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7897983
• 关键词: Human; Genetic; Analysis; Resource

This Human Genetic Analysis Resource will facilitate the identification, mapping and characterization of genes that cause complex diseases in man. The Resource will provide services and expertise in human genetic analysis to research workers investigating the familial nature of such diseases. Further statistical methods of analysis and study designs will be developed for this purpose, and well-documented, userfriendly computer programs prepared that can be easily tailored to the needs of other human geneticists and epidemiologists. Theoretical developments will include studies of validity, power and robustness of all procedures developed. Methods of association, segregation and linkage analysis will allow for, e.g., nonnormality, multifactorially caused familial correlations, measured and non-measured environmental effects, both Mendelian and non-Mendelian genetic effects, and non-random sampling. Consulting services in the use of these methods will be provided, and the methods will be applied in collaborative research to several broad areas, including cancer, pulmonary/ cardiovascular diseases, ophthalmologic diseases, neurological diseases, autoimmune diseases, and renal diseases. Human genetic analysts will be trained at the pre- and post-doctoral levels, and short courses given, both nationally and internationally, to train people in statistical analysis for genetic epidemiology and in the use of the computer programs that will be developed. Information about the Resource and its activities will be broadly disseminated at national and international meetings and by maintaining a home page on the World Wide Web.

该人类遗传分析资源将有助于识别、绘图和表征 导致人类复杂疾病的基因。该资源将提供人力资源方面的服务和专业知识 为研究此类疾病的家族性质的研究人员提供遗传分析。进一步统计 为此目的将开发分析和研究设计的方法，并且有详细记录，用户友好 编写的计算机程序可以轻松地根据其他人类遗传学家的需求进行定制 和流行病学家。理论发展将包括对所有方法的有效性、功效和鲁棒性的研究 制定了程序。关联、分离和连锁分析方法将允许例如非正态性、 多因素引起的家庭相关性、测量和非测量的环境影响， 孟德尔和非孟德尔遗传效应，以及非随机抽样。咨询服务在 将提供这些方法的使用，并且这些方法将应用于多个领域的合作研究 广泛的领域，包括癌症、肺/心血管疾病、眼科疾病、神经系统疾病 疾病、自身免疫性疾病和肾脏疾病。 人类基因分析师将接受博士前和博士后级别的培训，并提供短期课程， 在国内和国际上培训遗传流行病学统计分析和遗传流行病学统计分析方面的人员 使用将要开发的计算机程序。有关资源及其活动的信息将 在国家和国际会议上广泛传播，并在 全球资讯网。