STUDIES IN ALZHEIMER'S DISEASE

阿尔茨海默病的研究

• 批准号: 8171733
• 负责人: Robert C. Elston
• 金额: $ 0.49万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171733
• 关键词: African; African American; Alzheimer' s Disease; Apolipoprotein E; Cognitive; Communities; Computer Retrieval of Information on Scientific Projects Database; Dementia; Disease; Education; Elderly; Funding; Gene Frequency; Grant; Institution; Interview; Kenya; Language; Methods; Nigeria; Research; Research Personnel; Resources; Sampling; Screening procedure; Sensitivity and Specificity; Source; Susceptibility Gene; Translating; United States National Institutes of Health; age related; informant; vascular factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous studies have established cross-cultural methods to screen for ageing- related dementia and susceptibility genes, in particular Alzheimer's disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant function (DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100% sensitivities, the specificities of the DF scores were remarkably similar (93.75%) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E epsilon 4 allele frequencies were high (approximately 30%) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 先前的研究已经建立了跨文化方法，以筛选相关的痴呆症和易感基因，尤其是尼日利亚的加拿大克里，非裔美国人和约鲁巴人中的阿尔茨海默氏病（AD）。我们确定了痴呆症的社区筛查访谈（CSID）是否可以使用肯尼亚的主要语言Kikuyu来评估阿尔茨海默氏症类型的痴呆症。使用两组认知和线人得分的系数，计算了100个老年人（> 65年）Nyeri Kenyans中的每个判别功能（DF）得分。当选择100％敏感性的截止点时，在肯尼亚样本中，DF评分的特异性非常相似（93.75％）。我们建议可以利用改编的CSID来检测东非人之间的痴呆症。我们还表明，载脂蛋白E EPSILON 4等位基因频率很高（约30％），并且在正常受试者和可能AD的受试者之间没有差异。没有证据表明教育多年或血管因素与痴呆状态有关。