STUDIES IN ALZHEIMER'S DISEASE

阿尔茨海默病的研究

• 批准号: 8171733
• 负责人: Robert C. Elston
• 金额: $ 0.49万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171733
• 关键词: African; African American; Alzheimer' s Disease; Apolipoprotein E; Cognitive; Communities; Computer Retrieval of Information on Scientific Projects Database; Dementia; Disease; Education; Elderly; Funding; Gene Frequency; Grant; Institution; Interview; Kenya; Language; Methods; Nigeria; Research; Research Personnel; Resources; Sampling; Screening procedure; Sensitivity and Specificity; Source; Susceptibility Gene; Translating; United States National Institutes of Health; age related; informant; vascular factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous studies have established cross-cultural methods to screen for ageing- related dementia and susceptibility genes, in particular Alzheimer's disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant function (DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100% sensitivities, the specificities of the DF scores were remarkably similar (93.75%) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E epsilon 4 allele frequencies were high (approximately 30%) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 先前的研究已经建立了跨文化方法来筛查与衰老相关的痴呆症和易感基因，特别是加拿大克里族人、非裔美国人和尼日利亚约鲁巴人中的阿尔茨海默病（AD）。我们确定了痴呆症社区筛查访谈（CSID）（翻译成肯尼亚主要语言基库尤语）是否可用于评估阿尔茨海默型痴呆症。使用两组认知和知情者得分系数，为 100 名老年人（> 65 岁）Nyeri 肯尼亚人每人计算了两个判别函数 (DF) 得分。当选择 100% 敏感性的截止点时，肯尼亚样本中 DF 分数的特异性非常相似 (93.75%)。我们建议改编后的 CSID 可用于检测东非人的痴呆症。我们还表明，载脂蛋白 E epsilon 4 等位基因频率很高（约 30%），并且在正常受试者和可能患有 AD 的受试者之间没有差异。没有证据表明受教育年限或血管因素与痴呆状态有关。