Tissue Procurement

组织采购

• 批准号: 8181103
• 负责人: JONATHAN R POLLACK
• 金额: $ 8.24万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8181103
• 关键词: Accountability; Area; Autopsy; Blood specimen; Cancer Center; Cancer Patient; Cells; Collection; Consent; DNA; Data; Databases; Ensure; Equipment and supply inventories; Fees; Freezing; Future; Genomics; Goals; Individual; Leukocytes; Link; Malignant Neoplasms; Normal tissue morphology; Paraffin; Patients; Plasma; Policies; Process; Proteomics; Recommendation; Research; Research Personnel; Resource Sharing; Services; Specimen; Staining method; Stains; Standardization; Technology; Tissue Banking; Tissue Banks; Tissue Procurements; Tissues; Tumor Tissue; Universities; Work; anticancer research; cancer genomics; cancer stem cell; cost; experience; medical schools; meetings; molecular imaging; operation; programs; repository; surgery material; tumor; virtual

The overall objective of the Tissue Procurement Facility (TPF) Shared Resource is to procure and provide needed tissue specimens to Stanford Cancer Center investigators to support their cancer-related research. TPF activities and services include collecting and banking freshly frozen tumor and normal tissue from excess surgical material and from autopsy, providing fresh tumor tissue for viable cell studies, processing and banking blood specimens (plasma, serum, leukocyte DNA) from cancer patients, maintaining a tissue database with links to clinicopathological data, providing histological staining and pathological review and coordinating patient consent and ensuring regulatory compliance. As a centralized shared resource, the TPF adds value through experience, efficiency, standardization, accountability, protection of patient confidentially and timely completion of research. An oversight committee provides recommendations on facility policies and activities, and performs scientific and logistical review of service requests. Though largely supported by the Cancer Center and the School of Medicine, operating costs are defrayed by modest user fees. In the past 12 months alone, the TPF has provided over 450 fresh and frozen tissue specimens to 25 Cancer Center investigators from eight Cancer Center programs, to support cutting-edge cancer research in diverse areas, including cancer genomics, cancer stem cells and molecular imaging. The TPF also provides a portal to a "virtual bank" linking inventories of specialized "satellite" repositories, including collections of hematological and neurosurgical specimens. Future plans include increasing specimen capture to meet growing investigator needs, and expanding a new paraffin block collection.

组织采购设施 (TPF) 共享资源的总体目标是为斯坦福癌症中心的研究人员采购和提供所需的组织标本，以支持他们的癌症相关研究。 TPF 的活动和服务包括从多余的手术材料和尸检中收集和储存新鲜冷冻的肿瘤和正常组织，为活细胞研究提供新鲜的肿瘤组织，处理和储存癌症患者的血液样本（血浆、血清、白细胞 DNA），维护具有临床病理学数据链接的组织数据库，提供组织学染色和病理学审查，并协调患者同意并确保监管合规性。作为集中共享资源，TPF 通过经验、效率、标准化、问责制、患者机密保护和及时完成研究来增加价值。监督委员会就设施政策和活动提供建议，并对设施进行科学和后勤审查 服务请求。尽管很大程度上得到了癌症中心和医学院的支持，但运营成本是通过适度的使用费来支付的。仅在过去 12 个月内，TPF 就已向来自 8 个癌症中心项目的 25 名癌症中心研究人员提供了超过 450 份新鲜和冷冻组织标本，以支持癌症基因组学、癌症干细胞和分子成像等不同领域的前沿癌症研究。 TPF 还提供了一个连接专门“卫星”存储库库存的“虚拟银行”门户，其中包括血液学和神经外科标本的收藏。未来的计划包括增加标本采集以满足不断增长的研究人员需求，以及扩大新的石蜡块收藏。