Methods Core

方法核心

基本信息

批准号：
10631220
负责人：
BRUCE Lawrence ROLLMAN
金额：
$ 146.29万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-17 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10631220
关键词：
Adult Advanced Development Area Autopsy Award Black race Caregivers Cellular Phone Childhood Clinical Collaborations Consent Data Database Management Systems Development Electronic Health Record Eligibility Determination Emerging Technologies Ensure Evaluation Faculty Future Goals Health Insurance Portability and Accountability Act Health Services Research Healthcare Infrastructure Intervention Knowledge Machine Learning Medical center Mental Depression Mental Health Mental Health Services Methodology Methods Natural Language Processing Online Systems Patients Predictive Analytics Prevention Research Primary Care Provider Qualitative Methods Qualitative Research Reporting Research Research Methodology Research Personnel Resource Sharing Resources Risk Risk Assessment Safety Scientist Site Software Design Standardization Structure Teenagers Testing Text Training Universities Update Work Youth adolescent suicide analytical method career comorbidity cultural competence data centers data management data sharing experience follow up assessment health equity health equity promotion high-risk adolescents human centered design implementation science improved innovation integrated care machine learning algorithm mobile sensing patient engagement primary care practice primary care setting programs psychologic recruit screening service engagement suicidal suicidal behavior suicidal risk therapy development uptake

项目摘要

The Specific Aims of the Methods Core are to support a shared infrastructure that will enable ETUDES investigators to efficiently conduct the proposed Signature R01 which includes “Prediction and Assessment of Risk in Teens” (PART) and “integrated Care to Help At-Risk Teens” (iCHART) RCT, and three R34 treatment development studies described within this competitive renewal of our current P50 Center award. This Core will also advance the development of several emerging technologies to identify youth at risk for suicide with a special focus on engaging Black youth; advancing health equity; support and expand the number of early career scientists (ECSs) engaged in adolescent suicide prevention research; and serve as both a local and national resource sharing research expertise and new knowledge. The Methods Core will provide operational, analytic, and development support to achieve these aims through: (1) Shared data management and statistical collaboration to provide consistent and efficient support across all ETUDES Center studies; (2) Use of proven- effective, HIPAA-compliant and scalable methods to identify and consent study patients and meet recruitment targets without burdening busy providers and office staff; (3) Support for a centralized, well-supervised, highly trained, and culturally-competent team of assessors who will confirm subject eligibility, administer a standardized battery of baseline and follow-up assessments, and promote subject retention; (4) Support emerging smartphone research methods including mobile sensing of smartphone data and an update of the psychologic autopsy for the 21’st Century; (5) Machine learning and natural language processing of free-text unstructured electronic health records to predict suicidal behavior; (6) Expertise in qualitative research methods and human-centered design to engage patients, caregivers, and providers and iteratively improve our interventions and inform new Center projects; and (7) Application of implementation science methods to ensure our predictive analytic methods and interventions promote health equity and meet the needs of patients, caregivers, and providers in pediatric primary care to optimize future uptake.

方法核心的具体目标是支持共享基础设施，使 ETUDES 调查人员有效地执行拟议的签名 R01，其中包括“预测和评估青少年的风险”(PART) 和“帮助高危青少年的综合护理”(iCHART) RCT，以及三种 R34 治疗我们当前 P50 中心奖项的竞争更新中描述了发展研究。还推动了一些新兴技术的开发，以识别有自杀风险的青少年关注黑人青年的参与；促进健康公平；支持和扩大早期职业的数量；从事青少年自杀预防研究的科学家（ECS）；并作为地方和国家的科学家资源共享研究专业知识和新知识。方法核心将提供操作、分析、通过以下方式实现这些目标的发展支持： (1) 共享数据管理和统计合作为所有 ETUDES 中心研究提供一致和有效的支持；(2) 使用经过验证的- 有效、符合 HIPAA 且可扩展的方法来识别和同意研究患者并满足招募要求（三）支持集中、监督、高度集中训练有素且具有文化能力的评估员团队将确认受试者资格，管理标准化 (4) 支持新兴智能手机研究方法包括智能手机数据的移动传感和心理尸检的更新 21世纪；（5）自由文本非结构化电子的机器学习和自然语言处理预测自杀行为的健康记录；（6）定性研究方法和以人为本的专业知识；旨在吸引患者、护理人员和提供者，并迭代改进我们的干预措施并为新的信息提供信息中心项目；以及 (7) 应用实施科学方法来确保我们的预测分析方法和干预措施促进健康公平并满足患者、护理人员和提供者的需求儿科初级保健，以优化未来的吸收。