Tissue Procurement Facility

组织采购设施

• 批准号: 7438468
• 负责人: JONATHAN R POLLACK
• 金额: $ 3.55万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-04 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7438468
• 关键词: Accountability; Autopsy; Breast; Cancer Center; Cancer Patient; Cells; Clinical; Collection; Consent; Data; Databases; Equipment and supply inventories; Freezing; Future; Gene Expression; Link; Malignant Neoplasms; Malignant neoplasm of prostate; Normal tissue morphology; Paraffin Tissue; Patients; Policies; Process; Recommendation; Research; Research Personnel; Research Support; Resource Sharing; Serum; Services; Specimen; Staining method; Stains; Standardization; Tissue Procurements; Tissues; Tumor Tissue; Universities; base; clinically relevant; experience; member; programs; repository; surgery material; tumor; virtual

The overall objective of the Tissue Procurement Facility (TPF) is to procure and provide needed tissue specimens to Stanford University Cancer Center investigators to support their cancer-related research. TPF activities and services include collecting and banking freshly-frozen tumor and normal tissues from excess surgical material and from autopsy, providing fresh tumor tissue for viable cell studies, processing and banking serum specimens from cancer patients, maintaining a tissue database with links to clinicopathological data, providing histological staining and pathological review, and coordinating patient consent and assuring regulatory compliance. As a centralized Shared Resource, the TPF adds value through experience, efficiency, standardization, accountability, protection of patient confidentially, and timely completion of research. An advisory board provides recommendations on facility policies and activities, and performs scientific and logistical review of service requests. In FY2005 the TPF, and satellite repositories, have provided tissue specimens to Cancer Center members representing 8 out of 10 Programs. Highlights of the research supported by the Facility include the discovery of clinically-relevant gene-expression subtypes of breast and prostate cancers. The TPF also provides a portal to a "virtual bank" linking inventories of specialized "satellite" repositories, including collections of hematological and neurosurgical specimens. Future plans include an expansion of universal-consent based tissue procurement, increased efforts to bank both paraffin tissue blocks and viable cells, and more detailed clinical annotation of tissue specimens.

组织采购设施（TPF）的总体目标是采购并提供所需的组织 向斯坦福大学癌症中心研究人员的标本支持其与癌症相关的研究。 TPF的活动和服务包括收集和银行新鲜肿瘤和正常组织 过多的手术材料和尸检，为可行的细胞研究提供新鲜的肿瘤组织， 来自癌症患者的加工和银行血清标本，维持具有链接的组织数据库 到临床病理学数据，提供组织学染色和病理综述，并协调 患者同意并确保法规合规性。作为集中式共享资源，TPF添加了 通过经验，效率，标准化，问责制，保护患者的价值 秘密，及时完成研究。顾问委员会提供有关 设施政策和活动，并对服务请求进行科学和后勤回顾。在2005财年 TPF和卫星存储库已向癌症中心成员提供组织标本 代表10个计划中的8个。该设施支持的研究的亮点包括 发现与乳腺癌和前列腺癌的临床相关基因表达亚型。也是TPF 为“虚拟银行”提供了一个门户网站，该门户将专业的“卫星”存储库链接起来，包括 血液学和神经外科标本的集合。未来计划包括扩展 基于通用的基于组织的组织采购，增加了对融资石蜡组织块和 生存的细胞，以及组织标本的更详细的临床注释。