BIOSTATISTICS AND INFORMATICS

生物统计学和信息学

基本信息

批准号：
8181004
负责人：
SUSAN G. HILSENBECK
金额：
$ 22.06万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-17 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8181004
关键词：
Address Adult Architecture Area Basic Science Bioinformatics Biological Markers Biology Biometry Biostatistics Shared Resource Breast Cancer Center Cancer Center Support Grant Cancer Grant Supplements (P30)Capital Cellular biology Chad Charge Childhood Clinical Clinical Data Clinical Research Clinical Trials Collaborations Commit Common Data Element Communities Complex Computer software Conduct Clinical Trials Conflict of Interest Contracts DNA Sequence Data Data Analyses Data Base Management Databases Development Discipline Doctor of Philosophy Educational process of instructing Equipment Evaluation Experimental Designs Faculty Fellowship Flow Cytometry Shared Resource Funding Funding Agency Future Genomics Goals Grant Guidelines Human Resources Informatics Information Management Journals Laboratories Laboratory Study Leadership Left Link Malignant Neoplasms Management Information Systems Medical Medicine Methodology Methods Microscopy Mission Molecular Molecular Medicine Monitor Names Nuclear Receptors Paper Pathology Pediatrics Phase II Clinical Trials Play Police Population Sciences Postdoctoral Fellow Preparation Process Production Prostate Published Comment RNA Interference Recording of previous events Recovery Recruitment Activity Reporting Reproduction spores Research Research Infrastructure Research Personnel Research Project Grants Research Support Resource Sharing Resources Review Committee Role Schedule Schools Scientist Screening procedure Services Source Statistical Data Interpretation Strategic Planning Students Supervision System Time Tissue Banking Tissue Banks Training Training Programs Training and Education United States National Institutes of Health Vendor Vocabulary Work anticancer research base cancer Biomedical Informatics Grid cancer cell cancer prevention college cost cost effective data management data mining data sharing design epigenomics experience gene therapy genome-wide high throughput technology improved informatics shared resource interest interoperability meetings member new technology next generation novel strategies oncology open source programs protein expression research study skills tool working group

项目摘要

Biostatistics shared resources have, from the beginning of cancer centers, been a centerpiece of the infrastructure that underpins and adds value to a cancer center. The same holds true today, although needs continue to evolve. At present, within the Dan L Duncan Cancer Center, the Biostatistics and Informatics Shared Resource plays a critical role, and going forward into the next funding period, we propose changes and strategic enhancements that will continue to provide the best possible support of research at the Cancer Center. The resource was initially established as part of the first CCSG application in 2006. The Resource grew, primarily, out of existing capabilities and personnel in the biostatistics group in the Breast Center. Directed by Dr. Susan Hilsenbeck, this group had already established strong grant-funded collaborations with non-Breast Center investigators in what is now the Cancer Cell and Gene Therapy Program, the Nuclear Receptors Program, and the Cancer Prevention and Population Science Program, as well as a broad spectrum of investigators in the Breast Program. During our first funding period we continued to grow strategically, adding faculty, staff and services, according to the plan put forward in our initial application, and to address Cancer Center needs. We first added faculty and staff to increase support for bioinformatic analyses. We expanded expertise to support clinical trials, and now, in this competing renewal, propose to formally add support for other kinds of informatics by inclusion of the Cancer Center's developing informatics group. The primary purpose of the Resource is to support the research efforts of Cancer Center investgators through collaboration on biostatistical and informatic aspects of design, conduct, analysis, and interpretation of clinical and basic science studies. This will be accomplished by providing biostatistical and bioinformatic assistance (general consultation, experimental design, assistance with conduct of clinical trials, statistical analysis, methodologic development and interpretation); informatic support (project management, IT/hardware management, and database development including caBlG integration); statistical review for PRMS and education and training. Future plans include additional faculty and staff recruitment, development of better systems for clinical data management and reporting, and assisting high throughput technology-oriented share-resources, such as the Integrated Microscopy SR or the new Genome-Wide RNAi Screening and Analysis SR, with improved data management and analysis pipelines.

从癌症中心成立之初起，生物统计共享资源就一直是支撑癌症中心并为其增值的基础设施的核心。尽管需求在不断发展，但今天同样如此。目前，在 Dan L Duncan 癌症中心内，生物统计和信息学共享资源发挥着至关重要的作用，进入下一个资助期，我们提出变革和战略增强，这将继续为该中心的研究提供尽可能最好的支持。癌症中心。该资源最初是作为 2006 年第一个 CCSG 应用程序的一部分而建立的。主要是在乳腺中心生物统计小组的现有能力和人员的基础上发展起来的。在 Susan Hilsenbeck 博士的指导下，该小组已经与非乳腺中心研究人员建立了强有力的资助合作关系，即现在的癌细胞和基因治疗计划、核受体计划以及癌症预防和人口科学计划，以及乳房计划中广泛的研究人员。在我们的第一个资助期间，我们继续进行战略性增长，根据我们最初申请中提出的计划增加教职员工和服务，并满足癌症中心的需求。我们首先增加了教职员工以增加对生物信息学分析的支持。我们扩大了专业知识以支持临床试验，现在，在这一竞争性的更新中，我们提议通过纳入癌症中心正在发展的信息学小组来正式增加对其他类型信息学的支持。该资源的主要目的是通过临床和基础科学研究的设计、实施、分析和解释的生物统计和信息方面的合作来支持癌症中心研究人员的研究工作。这将通过提供生物统计和生物信息协助（一般咨询、实验设计、临床试验协助、统计分析、方法开发和解释）来实现；信息支持（项目管理、IT/硬件管理和数据库开发，包括caBlG集成）； PRMS 以及教育和培训的统计审查。未来的计划包括增加教职员工招募、开发更好的临床数据管理和报告系统，并通过改进的数据管理和分析管道协助高通量技术导向的共享资源，例如集成显微镜 SR 或新的全基因组 RNAi 筛选和分析 SR。