Biostatistics, Information, and Computational Biology

生物统计学、信息和计算生物学

• 批准号: 10460210
• 负责人: SUSAN G. HILSENBECK
• 金额: $ 27.18万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-19 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10460210
• 关键词: Bioinformatics; Biometry; Cancer Center; Clinical; Clinical Trials; Collaborations; Complex; Comprehensive Cancer Center; Computational Biology; Computer software; Computerized Medical Records Systems; Consultations; Cost Sharing; Custom; Data Analyses; Data Management Resources; Data Reporting; Database Management Systems; Databases; Development; Ensure; Experimental Designs; Fertilization; Genomics; Human Resources; Informatics; Institution; Licensing; Maintenance; Medicine; Methods; Pathology; Proteome; Randomized; Research Personnel; Resources; Sample Size; Science; Services; Testing; Translational Research; biobank; biomedical informatics; college; cost effectiveness; data management; data sharing; design; experience; experimental study; flexibility; informatics shared resource; malignant breast neoplasm; member; pre-clinical; proteogenomics; skills; statistics; tool

PROJECT SUMMARY In this renewal SPORE application, the former Biostatistics and Data Management Core is renamed to better reflect our expanded services. We have considerable experience working as a team with groups of investigators in general and this group of SPORE investigators in particular. All projects in our SPORE application will require statistical support for a range of preclinical and clinical experiments. All three projects propose clinical trials, and we have a strong track record of electronic clinical trial data management for both small single institution trials and more complex randomized multi-institution trials. All projects will also benefit from our expanded support for bioinformatics and integrative proteogenomic analysis. We also provide data management support to Core 1 (Pathology and Biobanking). New informatic development in support of biobanking and clinical annotation, undertaken and cost shared with several other large projects is a significant benefit to the SPORE. In our experience, centralized quantitative science support ensures that the biostatisticians, bioinformaticians and informatics professionals are completely familiar with all aspects of the Projects and Cores. This provides continuity, increases efficiency, and ensures that appropriate methods are applied. This also increases cross-Project data sharing. The Informatics and Statistics Core (ISC) will provide three broad types of services: (1) Comprehensive biostatistical consultation, experimental design, data analysis and reporting; (2) Integrative proteome-genomic bioinformatic consultation, experimental design, data analysis and reporting; (3) Development, customization, integration and maintenance of databases and data management systems to support data management needs of SPORE projects and cores. As a by-product, when necessary, the Core can also develop new methods or adapt existing methods from other arenas to meet the unique needs of the SPORE. The SPORE benefits greatly from having a dedicated and experienced team with a range of skills. The Core can also draw flexibly on the resources and personnel in the Cancer Center Biostatistics and Informatics Shared Resource and the Zhang Lab to augment expertise, or alter access to resources as needs change. Sample size considerations, experimental designs, and overviews of planned analyses for all projects were prepared in collaboration with the Core. In addition, deep understanding of SPORE data and analysis needs, in turn, drives database and application development, ensuring that informatic solutions meet the broad, as well as project-specific, needs of the SPORE. A hallmark of SPOREs is flexibility to terminate futile studies and pursue new leads. With dedicated Core personnel, we can also help investigators design new studies and test new hypotheses that may arise by cross-fertilization of these related projects.

项目概要 在此更新的 SPORE 应用程序中，以前的生物统计和数据管理核心更名为 更好地反映我们扩展的服务。我们拥有丰富的团队合作经验 一般调查员，特别是这组 SPORE 调查员。我们 SPORE 中的所有项目 应用程序需要一系列临床前和临床实验的统计支持。所有三个项目 提出临床试验，我们在电子临床试验数据管理方面拥有良好的记录 小型单机构试验和更复杂的随机多机构试验。所有项目也将受益 来自我们对生物信息学和综合蛋白质组分析的扩大支持。我们还提供数据 对核心 1（病理学和生物样本库）的管理支持。新的信息化发展支持 与其他几个大型项目进行生物样本库和临床注释并分担成本是一项重要的工作 对孢子有好处。 根据我们的经验，集中的定量科学支持可确保生物统计学家， 生物信息学家和信息学专业人员完全熟悉该项目的各个方面，并且 核心。这提供了连续性，提高了效率，并确保应用适当的方法。这 还增加了跨项目数据共享。信息学和统计核心（ISC）将提供三个广泛的 服务类型：（1）综合生物统计咨询、实验设计、数据分析和 报告； (2) 蛋白质组-基因组综合生物信息咨询、实验设计、数据分析和 报告； (3) 数据库和数据管理的开发、定制、集成和维护 支持 SPORE 项目和核心的数据管理需求的系统。作为副产品，必要时， 核心还可以开发新方法或采用其他领域的现有方法来满足独特的需求 孢子的。 SPORE 受益于拥有一支敬业且经验丰富且具备各种技能的团队。这 Core还可以灵活利用癌症中心生物统计和信息学的资源和人员 共享资源和张实验室可增强专业知识，或根据需求变化改变对资源的访问。 所有项目的样本量考虑、实验设计和计划分析概述 与核心合作准备。此外，对SPORE数据和分析需求的深入理解，在 反过来，推动数据库和应用程序开发，确保信息解决方案满足广泛的需求 SPORE 项目特定的需求。 SPORE 的一个特点是能够灵活地终止徒劳的研究并追求 新的线索。凭借专门的核心人员，我们还可以帮助研究人员设计新的研究并测试新的研究 这些相关项目的交叉作用可能产生的假设。