THE INTERFERON RESPONSE OF A MODEL CHIROPTERAN BAT; THE BLACK FLYING FOX, PTEROP

翼手目蝙蝠模型的干扰素反应；

• 批准号: 8168271
• 负责人: MICHELLE L BAKER
• 金额: $ 4.52万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168271
• 关键词: Antiviral Agents; Chiroptera; Clinical; Computer Retrieval of Information on Scientific Projects Database; Disease; Family Pteropodidae; Funding; Genus Pteropus; Grant; Human; Immune response; Immune system; Immunity; Institution; Interferons; Livestock; Modeling; Nose; Population; Predisposition; Reagent; Research; Research Personnel; Resources; Role; Simuliidae; Source; Symptoms; Syndrome; United States National Institutes of Health; Viral; Virus; Virus Diseases; companion animal; insight; mortality; response; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bats are natural host reservoirs for a variety of viruses, many of which are responsible for significant illness and mortality in humans, livestock and companion animals. Although bats may be persistently infected with many viruses, they rarely display clinical symptoms. Thus, bats appear to be able to co-exist with viruses and may have evolved mechanisms to rapidly control viral replication while still allowing transmission and occasional spillover to more susceptible species. In contrast to the ability of bats to tolerate viruses, the recent discovery of white nose syndrome (WNS), a fungal disease that has resulted in the devastation of some Northeastern US bat populations has revealed a potential susceptibility of bats to fungal diseases. Despite the devastation of bats due to WNS, and their central role in harboring and transmitting viral diseases, there is currently little information on the immune system of bats and few reagents exist to study the bat's immune response. Information on the immune response of bats would provide important insights into how bats escape the clinical manifestations of viral infection and the reasons for their susceptibility to WNS. In this proposal we are using the black flying fox, Pteropus alecto as a model to investigate the role of the interferon (IFN) response in antiviral immunity in bats to determine whether differences in the IFN response contribute to the ability of bats escape the clinical manifestations of disease following viral infection.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 蝙蝠是各种病毒的天然宿主储藏物，其中许多病毒造成了人类，牲畜和伴侣动物的重大疾病和死亡率。 尽管蝙蝠可能持续感染了许多病毒，但它们很少表现出临床症状。 因此，蝙蝠似乎能够与病毒共存，并可能发展了机制以快速控制病毒复制，同时仍可以传播和偶尔向更易感物种溢出。 与蝙蝠耐受病毒的能力相反，最近发现白鼻综合征（WNS）是一种真菌疾病，导致了一些美国东北蝙蝠种群的破坏，揭示了蝙蝠对真菌疾病的潜在敏感性。 尽管由于WNS引起的蝙蝠造成了破坏及其在携带和传播病毒疾病中的核心作用，但目前几乎没有关于蝙蝠的免疫系统的信息，并且很少有试剂无法研究BAT的免疫反应。有关蝙蝠免疫反应的信息将为蝙蝠如何逃脱病毒感染的临床表现以及其对WN敏感的原因提供重要的见解。 在此提案中，我们使用黑色飞狐，pteropus alecto作为研究蝙蝠中抗病毒药物在抗病毒药物中的作用（IFN）反应的作用，以确定IFN反应的差异是否有助于蝙蝠的能力逃脱临床表现。病毒感染后的疾病。