THE INTERFERON RESPONSE OF A MODEL CHIROPTERAN BAT; THE BLACK FLYING FOX, PTEROP

翼手目蝙蝠模型的干扰素反应；

• 批准号: 8360211
• 负责人: MICHELLE L BAKER
• 金额: $ 5.94万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360211
• 关键词: Antibodies; Antiviral Agents; Antiviral Response; Cell Line; Cells; Centers of Research Excellence; Chiroptera; Clinical; Coronavirus; Evolution; Family Pteropodidae; Funding; Gene Expression Profile; Genes; Genus Pteropus; Grant; Henipavirus; Human; Immune; Immune response; Immunity; Immunology; Interferons; Livestock; Mammals; Modeling; Morbidity - disease rate; National Center for Research Resources; Nature; Principal Investigator; Rabies virus; Reagent; Research; Research Infrastructure; Resources; Severe Acute Respiratory Syndrome; Simuliidae; Source; United States National Institutes of Health; Viral; Virus; Virus Diseases; companion animal; cost; gene discovery; insight; mortality; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bats are the natural host reservoir for a range of emerging and re-emerging viruses, including SARS-like Coronaviruses, Ebola, Henipaviruses and Rabies viruses. Many of the viruses carried by bats result in significant morbidity and mortality in humans, livestock and companion animals yet rarely result in clinical consequences in bats. However, the mechanisms responsible for the control of viral replication in bats are not understood and there is little information available on any aspect of antiviral immunity in bats. Our research seeks to understand the nature of antiviral immunity in bats using the model species, the Australian flying fox, Pteropus alecto. We are using a variety of approaches to examine the nature of innate and adaptive immune responses in bats including the characterization of genes known to be involved in antiviral immunity in other mammals and gene discovery using transcriptome analysis. We have also begun to investigate the expression of immune genes in virus infected cells and cell lines and develop bat specific antibody reagents. Understanding the antiviral responses of bats is crucial if we are to develop new treatments to control viral diseases in other mammals and will provide important insights into the evolution of antiviral immunity in mammals in general.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 蝙蝠是一系列新兴病毒的天然宿主储层，包括SARS样冠状病毒，埃博拉病毒，HENIPAVIRASE和狂犬病病毒。 蝙蝠携带的许多病毒导致人类，牲畜和伴侣动物的显着发病率和死亡率，但很少导致蝙蝠的临床后果。 但是，尚不了解负责控制蝙蝠病毒复制的机制，并且几乎没有有关蝙蝠抗病毒免疫力的任何信息。 我们的研究试图使用模型物种，澳大利亚飞狐，pteropus alecto了解蝙蝠中抗病毒免疫的性质。 我们正在使用多种方法来检查蝙蝠中先天和适应性免疫反应的性质，包括使用转录组分析的其他哺乳动物中已知的基因表征与其他哺乳动物中有关的基因和基因发现。 我们还开始研究病毒感染细胞和细胞系中免疫基因的表达，并发展出BAT特异性抗体试剂。 如果我们要开发新的治疗方法来控制其他哺乳动物的病毒疾病，并且将为哺乳动物的抗病毒免疫进化提供重要的见解，那么了解蝙蝠的抗病毒反应至关重要。