THE MAINTENANCE OF FETAL MATERNAL TOLERANCE IN MARSUPIALS

有袋动物胎儿母体耐受性的维持

• 批准号: 7171260
• 负责人: MICHELLE L BAKER
• 金额: $ 20.38万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171260
• 关键词: immunity; molecular genetics; immunity; molecular genetics

DESCRIPTION (provided by applicant): A unique confluence of expertise in the areas of evolutionary/ comparative and theoretical immunobiology currently exists among the community of scholars working in New Mexico. The primary goal of this proposal is, through the opportunities provided by the COBRE program; establish a research center at the University of New Mexico with a thematic focus in these disciplines. The center will strengthen the ties among these senior investigators and so create a nurturing and vibrant environment where junior scholars with interests in theoretical and evolutionary immunobiology can prosper intellectually and become independently funded to pursue their interests in this area. This proposal builds on a tangible commitment made by the Department of Biology at UNM to strengthen this research area, and will foster increased connectivity with outstanding investigators with similar interests in University of New Mexico (UNM) Department of Computer Science and the Los Alamos National Laboratories (LANL). The Santa Fe Institute (SFI), located midway between UNM and LANL, has in the past fostered close ties between the mentors and will serve as a venue for many programmatic events. Evolutionary and theoretical aspects of immunology increasingly need to lie within the purview of the NIH. Indeed, there is a growing awareness of the great value of a solid theoretical basis for understanding how host defense systems work when confronted with infectious organisms or neoplasia. Also, our understanding of the important but neglected field of innate immunity, including human innate immunity, has been significantly advanced by discoveries made with fruit flies, pointing out the value of comparative models in illuminating the functions of mammalian immune systems. We seek to create an environment that regularly brings theoreticians and empiricists together, thus gaining new theoretical and historical perspectives on how immune systems evolve, and how sustainable and effective defense from pathogens is achieved. This program features four projects by outstanding and eligible investigators who are currently in place. It will also enable us to hire new faculty members to gain additional critical mass in these research areas, and provides urgently needed funds to strengthen the research infrastructure for our investigators. The research areas outlined are recognized by the scientific community as exciting and important. New Mexico has a growing reputation of leadership in these areas, and they present a novel opportunity to promulgate an ascendant field in which New Mexicans can define the cutting edge and that can not be easily duplicated anywhere else in the world.

描述（由申请人提供）： 在新墨西哥州工作的学者社区中，目前存在着进化/比较和理论免疫生物学领域的专业知识的独特融合。 该提案的主要目标是通过毛毛额计划提供的机会；在新墨西哥大学建立一个研究中心，在这些学科中以主题为重点。 该中心将加强这些高级研究人员之间的联系，并创造一个充满活力和充满活力的环境，在该环境中，对理论和进化免疫生物学有兴趣的初级学者可以在理智上繁荣发展，并获得独立资助，以追求他们在这一领域的利益。 这项提案是基于生物学系在UNM上做出的切实承诺，以加强该研究领域，并将促进与新墨西哥大学（UNM）计算机科学系和洛斯阿拉莫斯国家实验室（LANL）相似的杰出研究人员的连通性。 位于UNM和Lanl之间的中途圣达菲研究所（SFI）过去曾在导师之间建立了紧密的联系，并将成为许多程序性活动的场所。 免疫学的进化和理论方面越来越需要属于NIH的权限。 确实，人们对了解宿主防御系统的良好价值的巨大价值越来越认识，当与传染性生物或肿瘤面对面时如何工作。 同样，我们对包括人类先天免疫在内的重要但被忽视的先天免疫领域的理解已经通过水果蝇的发现显着提高，并指出了比较模型在阐明哺乳动物免疫系统功能方面的价值。 我们试图创造一个定期将理论家和经验主义者聚集在一起的环境，从而获得有关免疫系统如何发展以及如何实现病原体的可持续和有效防御的新理论和历史观点。 该计划的特色是目前有杰出且合格的调查员的四个项目。 它还将使我们能够聘请新的教职员工在这些研究领域获得额外的临界量，并提供急需的资金来加强研究人员的研究基础设施。 概述的研究领域被科学界认为是令人兴奋和重要的。 新墨西哥州在这些领域的领导地位越来越多，他们提供了一个新的机会来颁布一个上升的领域，在该领域中，新墨西哥人可以定义最前沿，并且在世界其他任何地方都无法轻易复制。