MOLECULAR TARGETS FOR AA PROSTATE CANCER PATIENTS USING MIRNA PROFILING

使用 Mirna 分析确定 AA 前列腺癌患者的分子靶点

• 批准号: 8357143
• 负责人: Clayton Yates
• 金额: $ 8.65万
• 依托单位: TUSKEGEE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357143
• 关键词: African American; Biomedical Research; Cancer Patient; Caucasians; Caucasoid Race; Epigenetic Process; Funding; Gene Expression Regulation; Grant; Malignant neoplasm of prostate; MicroRNAs; Molecular Target; National Center for Research Resources; Principal Investigator; Regulation; Research; Research Infrastructure; Resources; Source; Testing; United States National Institutes of Health; cost; male; tumor; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall objective of this proposal is to test the hypothesis that differential expression of miRNA in African American vs Caucasian males contributes to the epigenetic regulation of gene expression throughout prostate cancer progression, and that this regulation is influenced by the tumor microenvironment.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该提案的总体目标是检验以下假设：非洲裔美国人与白人男性中 miRNA 的差异表达有助于整个前列腺癌进展过程中基因表达的表观遗传调控，并且这种调控受到肿瘤微环境的影响。