Racial and social contextual factors in relation to epigenome and bladder cancer outcome.

与表观基因组和膀胱癌结果相关的种族和社会背景因素。

• 批准号: 10762268
• 负责人: Nagireddy Putluri
• 金额: $ 4万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-21 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10762268
• 关键词: Address; African American; African American population; American; Antineoplastic Agents; Behavior; Biological; Biological Factors; Biology; Biomedical Research; Cancer Patient; Cancer Research Project; Carcinogens; Categories; Censuses; Characteristics; Clinical; Collaborations; Communities; Community Developments; Community Health; Comprehensive Cancer Center; Consent; Cross-Sectional Studies; Cystectomy; DNA; DNA Methylation; Data; Data Set; Development; Disadvantaged; Disease Progression; Disparate; Disparity; Drug Kinetics; Economics; Education; Environment; Environmental Risk Factor; Environmental and Occupational Exposure; Epigenetic Process; Ethnic Origin; European; Event; Exhibits; Faculty; Functional disorder; Genes; Geographic Information Systems; Health; Health Services Accessibility; Historically Black Colleges and Universities; Housing; Human; Incidence; Individual; Industry; Inferior; Infrastructure; Institution; Intervention; Interview; Interviewer; Joints; Life Cycle Stages; Link; Location; Malignant Neoplasms; Malignant neoplasm of urinary bladder; Measures; Mediating; Medicine; Methylation; Minority Groups; Modification; Molecular and Cellular Biology; Neighborhoods; Neoplasm Circulating Cells; Neoplasm Metastasis; Occupational; Occupational Exposure; Outcome; Outcome Measure; Pathway interactions; Patients; Persons; Pilot Projects; Plants; Play; Policies; Policy Research; Printing; Prognostic Marker; Public Health; Race; Recording of previous events; Reporting; Research; Resource Sharing; Risk; Role; Rubber; Running; Smoking History; Social Environment; Source; Specimen; Surveys; Testing; Texas; Textiles; Tissue Sample; Tumor Bank; U.S. Department of Housing and Urban Development; Universities; Work; Workplace; Xenobiotics; anticancer research; built environment; cancer health disparity; carcinogenicity; college; community engagement; contextual factors; drug discovery; education research; epigenome; epigenomics; ethnic minority; experience; health care availability; health data; health disparity populations; member; methylation pattern; mortality; neighborhood disadvantage; outreach; programs; racial disparity; racial minority; recruit; social culture; social factors; social health determinants; socioeconomics; software systems; stressor; timeline; tumor; tumor progression

CURED PILOT Project 2 Summary This proposal entails strengthening the efforts between Dan L Duncan Comprehensive Cancer Center (DLDCCC) at Baylor College of Medicine (BCM) and Texas Southern University (TSU), an institution serving underserved health disparity populations and a historically black college and university (HBCU), to establish the Baylor-Texas Southern P20 consortium or BCM-TSU P20 Collaborative Union for Cancer Research, Education and Disparities (CURED). BCM-TSU P20 CURED will develop the infrastructure for a cancer research program with a specific focus on cancer health disparities (including biology, outcomes, and access to treatment) and community engagement with a joint Cancer Research Education Program. This collaboration builds upon complementary expertise in cancer health disparities at DLDCCC/BCM and TSU, cancer drug discovery and pharmacokinetics at TSU, and robust patient and community- focused outreach and engagement focused on predominantly minority populations of both institutions with complementary expertise and allowance of shared resources and ongoing joint endeavors with both institutions. The proposal for BCM-TSU P20 CURED includes the Center of Excellence for Housing and Community Development Policy Research (CEHCDPR), a U.S. Department of Housing and Urban Development Center of Excellence, at TSU as a member of the research team. Faculty with CEHCDPR will partner with faculty from the Department of Molecular and Cellular Biology at BCM to study the associations between the social determinants of health (SDOH) and bladder cancer to understand the racial disparities in disease progression, in which African Americans experience more severe outcomes than Whites. CEHCDPR will develop a SDOH interviewer-administered survey that will include questions about socioeconomic characteristic, smoking history, and health care access, and residential and workplace history. BCM will administer the survey to consenting bladder cancer patients. Once BCM has completed the survey, CEHCDPR will use Geographic Information Systems software to geolocate each patient’s historical residential location. CEHCDPR will compile data layers from existing sources, including US Census and US EPA, on the socioeconomic and environmental conditions of the patient’s residential neighborhoods. Concurrently, BCM will run DNA testing of tissue samples from the patients who completed the survey. The CEHCDPR and BCM datasets will be combined and CEHCDPR will analyze the data to evaluate the association between the SDOH and the cancer DNA data.

固化飞行员项目2摘要 该提案需要加强丹·邓肯综合癌症中心之间的努力 （DLDCCC）在贝勒医学院（BCM）和德克萨斯州南部大学（TSU）的机构 为服务不足的健康差异人群以及历史悠久的黑人学院和大学（HBCU）服务， 建立Baylor-Texas Southern P20财团或BCM-TSU P20癌症协作联盟 研究，教育和差异（治愈）。 BCM-TSU P20固化将开发用于 癌症研究计划特别关注癌症健康分布（包括生物学，结果， 并获得治疗）和通过联合癌症研究教育计划的社区参与。 这项合作建立在DLDCCC/BCM癌症健康分布的完整专业知识的基础上 以及TSU的TSU，TSU的癌症药物发现和药代动力学以及健壮的患者和社区 - 重点关注的外展和参与重点是这两个机构的主要少数人口 具有完善的专业知识以及共享资源的津贴以及与 这两个机构。 BCM-TSU P20固化的建议包括住房和社区卓越中心 美国住房和城市发展中心部的发展政策研究（CEHCDPR） 卓越，在TSU担任研究团队的成员。与Cehcdpr的教师将与教师合作 来自BCM的分子和细胞生物学系，研究 健康的社会决定者（SDOH）和膀胱癌了解疾病的种族分布 进步，非裔美国人比白人更严重的结果。 Cehcdpr Will 制定SDOH面试官管理的调查，其中包括有关社会经济的问题 特征，吸烟历史和医疗保健访问以及居民和工作场所历史。 BCM Will 进行调查以同意膀胱癌患者。 BCM完成调查后， CEHCDPR将使用地理信息系统软件将每个患者的病史分解 居民位置。 CEHCDPR将从现有来源（包括美国人口普查和 美国EPA，关于患者居民社区的社会经济和环境状况。 同时，BCM将对完成调查的患者进行组织样品的DNA测试。 CEHCDPR和BCM数据集将组合，CEHCDPR将分析数据以评估 SDOH与癌症DNA数据之间的关联。