EVALUATION OF CALCIUM, VITAMIN D, MAGNESIUM AND ZINC ABSORPTION IN HEALTHY

评估钙、维生素 D、镁和锌的健康吸收情况

• 批准号: 8356713
• 负责人: STEVEN A ABRAMS
• 金额: $ 10.33万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356713
• 关键词: Affect; Age; Calcium; Child; Cholecalciferol; Clinical Research; Copper; Data; Development; Diet; Evaluation; Funding; Goals; Grant; Health; Human Experimentation; Intake; Iron; Magnesium; Methods; Minerals; Minerals Nutrition; National Center for Research Resources; Nutritional; Outcome; Population Study; Principal Investigator; Recommendation; Research; Research Infrastructure; Resources; Source; Supplementation; Techniques; United States National Institutes of Health; Vitamin D; Zinc; absorption; base; calcium absorption; control trial; cost; evidence base; nutritional guideline; stable isotope

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT The goal of our research is to provide data to enhance the development of nutritional guidelines, especially as related to mineral nutrition, in children. Using human experimentation, we are studying methods of delivering the key minerals of calcium, zinc and iron in the diet so as to optimize health outcomes. We will conduct a controlled trial of vitamin D supplementation to assess the effects of vitamin D status on calcium absorption in small children. We will evaluate the effects of differing intakes of zinc on zinc and copper absorption. These studies will utilize stable isotope techniques so as to provide accurate, practically applicable information which may be obtained from the study populations in a safe manner. These data will have global application and provide a strong basis for evidence-based nutritional recommendations to be developed. I. HYPOTHESIS Hypothesis #1: Calcium absorption will not be significantly affected by providing children 8 weeks of supplementation with 1000 IU/d of vitamin D3. Hypothesis #2: There will be no significant relationship between intake and true dietary absorption of zinc. There will be a significant negative relationship between magnesium intake and absorption efficiency. II. SPECIFIC AIMS Objective #1: To evaluate the effects of supplemental vitamin D in enhancing calcium absorption in healthy children 4 to 8 yrs of age. Objective #2: Assess the absorption of magnesium and zinc in healthy children 4 to 8 yrs of age.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 抽象的 我们研究的目的是提供数据，以增强儿童营养准则的制定，尤其是与矿物营养有关的数据。使用人类实验，我们正在研究饮食中钙，锌和铁的关键矿物质的方法，以优化健康结果。我们将进行补充维生素D的对照试验，以评估维生素D状态对小儿童钙吸收的影响。我们将评估锌不同摄入量对锌和铜吸收的影响。这些研究将利用稳定的同位素技术，以提供准确的，实际上适用的信息，这些信息可以安全地从研究人群中获得。这些数据将具有全球应用，并为要开发的基于证据的营养建议提供了强大的基础。 I.假设 假设1：通过为儿童提供8周补充维生素D3的儿童，钙吸收不会显着影响。 假设2：摄入量与锌的真正饮食吸收之间将没有显着关系。镁摄入量与吸收效率之间将存在显着的负相关关系。 ii。 具体目标 目标＃1：评估补充维生素D对增强4至8岁健康儿童钙吸收的影响。 目标＃2：评估健康儿童4至8岁的健康儿童的吸收。