VITAMIN D STATUS AND IMPACT ON BONE MINERALIZATION IN HUMAN MILK FED HISPANIC

母乳喂养的西班牙裔人的维生素 D 状况及其对骨矿化的影响

• 批准号: 8356696
• 负责人: STEVEN A ABRAMS
• 金额: $ 4.15万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356696
• 关键词: 25-hydroxyvitamin D; Age-Months; Autoimmune Diseases; Birth; Bone Mineral Contents; Breast Feeding; Caucasians; Caucasoid Race; Child; Childhood; Cholecalciferol; Clinical Research; Data; Disease; Dual-Energy X-Ray Absorptiometry; Frequencies; Funding; Grant; Hispanics; Human Milk; Immune; Individual; Infant; Intake; Life; Link; Malignant Neoplasms; Measures; Milk; Minerals; Mothers; National Center for Research Resources; Newborn Infant; Nutritional; Outcome; Physiologic calcification; Predisposition; Principal Investigator; Public Health; Relative (related person); Reporting; Research; Research Infrastructure; Resources; Rickets; Risk; Serum; Skin; Source; Speed; Sun Exposure; Supplementation; Texas; Ultrasonography; Umbilical Cord Blood; United States National Institutes of Health; Urbanization; Vitamin D; Vitamin D Deficiency; bone; bone health; cohort; cost; feeding; fetal; follow-up; high risk; imprint; neonate; sound; 25-hydroxyvitamin D; Age-Months; Autoimmune Diseases; Birth; Bone Mineral Contents; Breast Feeding; Caucasians; Caucasoid Race; Child; Childhood; Cholecalciferol; Clinical Research; Data; Disease; Dual-Energy X-Ray Absorptiometry; Frequencies; Funding; Grant; Hispanics; Human Milk; Immune; Individual; Infant; Intake; Life; Link; Malignant Neoplasms; Measures; Milk; Minerals; Mothers; National Center for Research Resources; Newborn Infant; Nutritional; Outcome; Physiologic calcification; Predisposition; Principal Investigator; Public Health; Relative (related person); Reporting; Research; Research Infrastructure; Resources; Rickets; Risk; Serum; Skin; Source; Speed; Sun Exposure; Supplementation; Texas; Ultrasonography; Umbilical Cord Blood; United States National Institutes of Health; Urbanization; Vitamin D; Vitamin D Deficiency; bone; bone health; cohort; cost; feeding; fetal; follow-up; high risk; imprint; neonate; sound

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT Vitamin D deficiency is widespread and linked to decreased bone mineral content. Little data exists regarding the vitamin D status and the relationship of 25-OHD status to functional bone health outcomes in Hispanic infants. To evaluate this, we plan an observational cohort of full term, healthy, exclusively breastfed Hispanic and Caucasian infants. We hypothesize serum 25-OHD measured in cord blood will be significantly lower in Hispanic than Caucasian infants, with 25-OHD 50% of Hispanic neonates. Hypothesis #2: Speed of sound bone ultrasound (SOS U/S) and dual-energy X-ray absorptiometry (DXA) whole body bone mineral content measured in the first week of life will correlate positively with 25-OHD concentration in cord blood. Hypothesis #3: Supplementation with 400 IU/d of vitamin D3 from birth will allow all infants to achieve 25-OHD levels 20 ng/mL. Baseline-adjusted bone mineral content and SOS U/S will be significantly correlated with 25-OHD status at 3 months. II. SPECIFIC AIMS Primary Aim: To evaluate the relative frequency of vitamin D deficiency in human milk fed Hispanic compared to Caucasian newborn infants in Houston, Texas. Secondary Aims: To determine if infant vitamin D status is related to bone mineral status at birth and to determine the effects of vitamin D supplementation on 25-hydroxyvitamin D (25-OHD) concentration and bone mineral status vitamin D deficient and vitamin D replete infants at 3 months of age. III. BACKGROUND AND SIGNIFICANCE In recent years, severe vitamin D deficiency has resurfaced as a major public health concern. Nutritional rickets is widespread, and a recent report on this disease in Texas showed Hispanic children are at increased risk. Long-term follow-up has demonstrated that vitamin D deficient infants are more likely to have decreased bone mineral status in late childhood. Additionally, vitamin D deficiency has been linked to changes in fetal imprinting and increased susceptibility to autoimmune diseases, immune deficiency, and malignancy. At birth, an infants vitamin D status is entirely dependent on the vitamin D status of the mother. Many studies have shown vitamin D deficiency is very common in mother-child pairs, especially in dark-skinned individuals. However, few data exist regarding the vitamin D status in Hispanic infants. Low milk intakes and decreased sun exposure with urbanization makes this a very high-risk group among infants in Texas.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 抽象的 维生素D缺乏症广泛，与骨矿物质含量降低有关。 关于维生素D状况以及25-OHD状态与西班牙裔婴儿功能性骨骼健康结果的关系很少。 为了评估这一点，我们计划了一个完整期限，健康，仅母乳喂养的西班牙裔和高加索婴儿的观察队列。 我们假设在西班牙裔中测得的血清血清25-OHD将明显低于高加索婴儿，其中25％的西班牙裔新生儿50％。 假设2：声骨超声（SOS U/s）和双能X射线吸收仪（DXA）在生命的第一周中测得的全身骨矿物质含量将与脐带血的25-OHD浓度呈正相关。 假设3：补充400 IU/d的维生素D3将使所有婴儿都能达到25欧元的水平20 ng/ml。基线调整后的骨矿物质含量和SOS U/S将与3个月时25-OHD状态显着相关。 ii。 具体目标 主要目的：评估与德克萨斯州休斯顿的高加索新生婴儿相比，人类牛奶中维生素D缺乏症的相对频率。 次要目的：确定婴儿维生素D状态是否与出生时的骨矿物质状态有关，并确定补充维生素D对25-羟基维生素D（25-OHD）浓度和骨矿物质状态D缺乏症和维生素D缺乏和维生素D的影响。 iii。 背景和意义 近年来，严重的维生素D缺乏症已重新浮出水面，这是一个主要的公共卫生问题。营养液能广泛，德克萨斯州这种疾病的最新报告显示，西班牙裔儿童的风险增加。长期随访表明，维生素D缺乏婴儿在儿童后期更有可能降低骨矿物质状态。此外，维生素D缺乏症与胎儿印记的变化以及对自身免疫性疾病，免疫缺陷和恶性肿瘤的敏感性增加有关。出生时，婴儿D状态完全取决于母亲的维生素D状态。许多研究表明，维生素D缺乏症在母子对，尤其是在黑皮肤的个体中很常见。但是，关于西班牙裔婴儿的维生素D状况的数据很少。低牛奶摄入量和随着城市化的阳光暴露减少，这使得这是德克萨斯州婴儿的高风险。