VITAMIN D STATUS AND IMPACT ON BONE MINERALIZATION IN HUMAN MILK FED HISPANIC

母乳喂养的西班牙裔人的维生素 D 状况及其对骨矿化的影响

基本信息

批准号：
8356696
负责人：
STEVEN A ABRAMS
金额：
$ 4.15万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-12-01 至 2011-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8356696
关键词：
25-hydroxyvitamin D Age-Months Autoimmune Diseases Birth Bone Mineral Contents Breast Feeding Caucasians Caucasoid Race Child Childhood Cholecalciferol Clinical Research Data Disease Dual-Energy X-Ray Absorptiometry Frequencies Funding Grant Hispanics Human Milk Immune Individual Infant Intake Life Link Malignant Neoplasms Measures Milk Minerals Mothers National Center for Research Resources Newborn Infant Nutritional Outcome Physiologic calcification Predisposition Principal Investigator Public Health Relative (related person)Reporting Research Research Infrastructure Resources Rickets Risk Serum Skin Source Speed Sun Exposure Supplementation Texas Ultrasonography Umbilical Cord Blood United States National Institutes of Health Urbanization Vitamin D Vitamin D Deficiency bone bone health cohort cost feeding fetal follow-up high risk imprint neonate sound

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT Vitamin D deficiency is widespread and linked to decreased bone mineral content. Little data exists regarding the vitamin D status and the relationship of 25-OHD status to functional bone health outcomes in Hispanic infants. To evaluate this, we plan an observational cohort of full term, healthy, exclusively breastfed Hispanic and Caucasian infants. We hypothesize serum 25-OHD measured in cord blood will be significantly lower in Hispanic than Caucasian infants, with 25-OHD 50% of Hispanic neonates. Hypothesis #2: Speed of sound bone ultrasound (SOS U/S) and dual-energy X-ray absorptiometry (DXA) whole body bone mineral content measured in the first week of life will correlate positively with 25-OHD concentration in cord blood. Hypothesis #3: Supplementation with 400 IU/d of vitamin D3 from birth will allow all infants to achieve 25-OHD levels 20 ng/mL. Baseline-adjusted bone mineral content and SOS U/S will be significantly correlated with 25-OHD status at 3 months. II. SPECIFIC AIMS Primary Aim: To evaluate the relative frequency of vitamin D deficiency in human milk fed Hispanic compared to Caucasian newborn infants in Houston, Texas. Secondary Aims: To determine if infant vitamin D status is related to bone mineral status at birth and to determine the effects of vitamin D supplementation on 25-hydroxyvitamin D (25-OHD) concentration and bone mineral status vitamin D deficient and vitamin D replete infants at 3 months of age. III. BACKGROUND AND SIGNIFICANCE In recent years, severe vitamin D deficiency has resurfaced as a major public health concern. Nutritional rickets is widespread, and a recent report on this disease in Texas showed Hispanic children are at increased risk. Long-term follow-up has demonstrated that vitamin D deficient infants are more likely to have decreased bone mineral status in late childhood. Additionally, vitamin D deficiency has been linked to changes in fetal imprinting and increased susceptibility to autoimmune diseases, immune deficiency, and malignancy. At birth, an infants vitamin D status is entirely dependent on the vitamin D status of the mother. Many studies have shown vitamin D deficiency is very common in mother-child pairs, especially in dark-skinned individuals. However, few data exist regarding the vitamin D status in Hispanic infants. Low milk intakes and decreased sun exposure with urbanization makes this a very high-risk group among infants in Texas.

该子项目是利用资源的众多研究子项目之一由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持并且子项目的主要研究者可能是由其他来源提供的，包括其他 NIH 来源。子项目可能列出的总成本代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。抽象的维生素 D 缺乏现象很普遍，并且与骨矿物质含量减少有关。关于西班牙裔婴儿维生素 D 状态以及 25-OHD 状态与功能性骨骼健康结果之间关系的数据很少。为了评估这一点，我们计划了一个由足月、健康、纯母乳喂养的西班牙裔和白人婴儿组成的观察队列。我们假设，西班牙裔婴儿脐带血中测得的血清 25-OHD 含量显着低于白人婴儿，西班牙裔新生儿中 25-OHD 含量占 50%。假设#2：声速骨超声 (SOS U/S) 和双能 X 射线吸收测定法 (DXA) 在生命第一周测量的全身骨矿物质含量将与脐带血中 25-OHD 浓度呈正相关。假设#3：从出生起每天补充 400 IU 维生素 D3 将使所有婴儿的 25-OHD 水平达到 20 ng/mL。基线调整后的骨矿物质含量和 SOS U/S 将与 3 个月时的 25-OHD 状态显着相关。二. 具体目标主要目的：评估德克萨斯州休斯顿的西班牙裔新生儿与白种人母乳喂养中维生素 D 缺乏的相对频率。次要目标：确定婴儿维生素 D 状态是否与出生时骨矿物质状态相关，并确定补充维生素 D 对 25-羟基维生素 D (25-OHD) 浓度和骨矿物质状态维生素 D 缺乏和维生素 D 补充婴儿的影响3个月大时。三．一、背景及意义近年来，严重的维生素 D 缺乏重新成为一个主要的公共卫生问题。营养性佝偻病很普遍，德克萨斯州最近关于这种疾病的一份报告显示，西班牙裔儿童的风险更高。长期随访表明，缺乏维生素 D 的婴儿在童年后期更有可能出现骨矿物质状况下降。此外，维生素 D 缺乏与胎儿印记的变化以及自身免疫性疾病、免疫缺陷和恶性肿瘤的易感性增加有关。出生时，婴儿的维生素 D 状况完全取决于母亲的维生素 D 状况。许多研究表明，维生素 D 缺乏症在母子中非常常见，尤其是深色皮肤的个体。然而，关于西班牙裔婴儿维生素 D 状况的数据很少。随着城市化进程，牛奶摄入量减少，阳光照射减少，使得这一人群成为德克萨斯州婴儿中的高危人群。