ZINC AND COPPER EXCRETION AND ABSORPTION IN INFANTS WITH OSTOMIES

造口婴儿的锌和铜排泄和吸收

• 批准号: 8356699
• 负责人: STEVEN A ABRAMS
• 金额: $ 1.02万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356699
• 关键词: Ceruloplasmin; Clinical Research; Copper; Enteral Feeding; Enteral Nutrition; Excretory function; Funding; Grant; Hour; Infant; Intestines; Measures; National Center for Research Resources; Ostomy; Output; Patients; Principal Investigator; Research; Research Infrastructure; Resources; Serum; Serum zinc level result; Source; Time; Total Parenteral Nutrition; United States National Institutes of Health; Zinc; absorption; cost; stable isotope

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. ABSTRACT We propose to examine the absorption and excretion of zinc and copper in infants with ostomies. This will be accomplished by measuring baseline excretion and serum levels of zinc, copper, and ceruloplasmin, and by utilizing stable isotopes of zinc and copper to measure absorption and excretion. When an infant with an ostomy is receiving primarily total parenteral nutrition (TPN) with minimal or no enteral feeds, we will collect ostomy output for 24 hours to measure zinc and copper excretion, and will measure serum zinc, copper, and ceruloplasmin levels. We will utilize stable isotopes of zinc and copper at two time points: when the infant still has the ostomy and is receiving primarily enteral nutrition without TPN, and lastly, when/if the patients ostomy is removed with the bowels reanastamosed and the patient is stable on enteral feeds.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 抽象的 我们建议检查术中锌和铜的吸收和排泄。这将通过测量基线排泄和锌，铜和ceruloplasmin的血清水平，以及利用锌和铜的稳定同位素来测量吸收和排泄。当造口术的婴儿主要接受最少或没有肠内饲料的总肠胃外营养（TPN）时，我们将收集骨术输出24小时以测量锌和铜排泄，并测量血清锌，铜和ceruloplasmin水平。我们将在两个时间点利用锌和铜的稳定同位素：当婴儿仍然具有骨术并主要接受不带TPN的肠内营养时，最后，当/如果/如果患者在肠道上切除患者的骨术时，则在肠道上切除了骨术，并且患者在肠内饲料上稳定。