NUTRITIONAL MANAGEMENT OF INFANTS WITH BRONCHOPULMONARY DYSPLASIA (BPD): EFFE

支气管肺发育不良 (BPD) 婴儿的营养管理：EFFE

• 批准号: 8166685
• 负责人: STEVEN A ABRAMS
• 金额: $ 0.78万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166685
• 关键词: Affect; Body Composition; Bronchopulmonary Dysplasia; Chronic; Computer Retrieval of Information on Scientific Projects Database; Disease Management; Funding; Grant; Growth; Growth and Development function; Head circumference; Hospitalization; Human Milk; Infant; Institution; Intake; Lead; Length; Liquid substance; Lung; Minerals; Nutritional; Outcome; Pulmonary Edema; Research; Research Personnel; Resources; Respiratory physiology; Source; United States National Institutes of Health; Very Low Birth Weight Infant; Weight Gain; bone; calcium absorption; calcium metabolism; density; expectation; feeding; improved; in utero

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bronchopulmonary Dysplasia (BPD) affects approximately one-fourth of very low birth weight infants (VLBW) and results in chronic pulmonary sequelae and the potential for impaired growth and development. Although somatic growth is associated with improved lung function, management of this disorder frequently includes fluid restriction to minimize pulmonary edema. The optimal way to maximize nutritional intake when fluid is restricted and the effects of the common practice of increasing caloric density (above 24 kcal/oz) on growth, calcium metabolism and bone mineral status are unknown. Despite restricted volume intake, providing either preterm formula or human milk fortified to 27 kcal/oz (0.9 kcal/mL) for 6 weeks to VLBW infants with evolving BPD will lead to calcium absorption, bone and somatic growth in infants comparable to infants who do not have BPD and are fed higher volumes of fortified human milk or formula at 24 kcal/oz (0.8 kcal/mL). These results will support the use of high caloric density feedings in infants with BPD to achieve both bone and overall growth outcomes close to those achievable in utero. Weight gain in each group will average 15-20 g/kg/d, consistent with expectations and mean length (1.0 cm/wk) and head circumference (0.8 cm/wk) will similarly increase at in utero levels. Primary Aim: To compare the effects of different feeding strategies on calcium absorption in Very Low Birth Weight (VLBW) infants with and without evolving bronchopulmonary dysplasia (BPD). Secondary Aim: To evaluate growth and body composition in VLBW infants provided 120 kcal/kg/d feeding during hospitalization.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 支气管肺发育不良（BPD）影响了大约四分之一的非常低的出生体重婴儿（VLBW），并导致慢性肺后遗症，并可能导致生长和发育受损。尽管体细胞生长与肺功能的改善有关，但该疾病的管理通常包括液体限制以最大程度地减少肺水肿。当液体受到限制时，最大化营养摄入量的最佳方法以及增加热量密度（高于24 kcal/oz）对生长，钙代谢和骨矿物质状态的常见实践的影响尚不清楚。 Despite restricted volume intake, providing either preterm formula or human milk fortified to 27 kcal/oz (0.9 kcal/mL) for 6 weeks to VLBW infants with evolving BPD will lead to calcium absorption, bone and somatic growth in infants comparable to infants who do not have BPD and are fed higher volumes of fortified human milk or formula at 24 kcal/oz (0.8 kcal/mL).这些结果将支持在BPD婴儿中使用高热量密度喂养，以达到骨骼和总体生长结果，接近子宫内可实现的结果。每组的体重增加平均为15-20 g/kg/d，与期望和平均长度（1.0 cm/wk）一致，并且头圆周（0.8 cm/wk）在子宫级水平上类似地增加。 主要目的：比较不同喂养策略对具有和不发展支气管肺发育不良（BPD）的非常低出生体重（VLBW）婴儿中钙吸收的影响。 次要目的：评估VLBW婴儿的生长和身体成分，在住院期间提供了120 kcal/kg/d的喂养。