COCHLEAR MECHANICS, WAVE PROPAGATION, AND COMPRESSION

耳蜗力学、波传播和压缩

• 批准号: 8047962
• 负责人: Stephen T Neely
• 金额: $ 37.5万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8047962
• 关键词: Accounting; Acoustic Nerve; Acoustics; Address; Amplifiers; Appearance; Area; Auditory; Basilar Membrane; Behavioral; Cochlea; Computer Simulation; Data; Development; Evaluation; Experimental Models; External auditory canal; Failure; Frequencies; Goals; Growth; Hearing; Hearing Aids; Hearing problem; Human; Individual; Lead; Linear Regressions; Liquid substance; Literature; Loudness; Masks; Measurement; Measures; Mechanics; Methods; Modeling; Nerve Fibers; Output; Peripheral; Phase; Property; Psychometrics; Public Health; Research; Research Design; Research Personnel; Sense Organs; Side; Signal Transduction; Simulate; Stimulus; Study models; Techniques; Testing; Time; Travel; Width; Work; base; clinically significant; design; experience; hearing impairment; human subject; method development; notch protein; novel; otoacoustic emission; pressure; programs; remediation; research study; response; sound; theories; two-dimensional

DESCRIPTION (provided by applicant): This research program focuses on theoretical and empirical studies that address current issues in cochlear mechanics relevant to noninvasive evaluation of cochlear function. The major objectives of these studies are to understand cochlear-wave propagation and to characterize cochlear compression. These objectives are approached through six specific aims. The first three aims focus on aspects of cochlear-wave propagation through modeling efforts directed at the following theoretical issues: (1) appropriate characterization of cochlear-amplifier gain; (2) a more complete understanding of distortion-product retrograde wave propagation; and (3) understanding the mechanisms that underlie notches in basilar-membrane measurements. The next three aims characterize cochlear compression growth through a combination of empirical studies involving human subjects and theoretical work involving models of cochlear mechanics. Specifically, these three studies are designed to increase our understanding of the relation between: (4) compression growth rate (CGR) and the slope of forward-masking psychometric functions; (5) CGR and suppression growth rate; and (6) CGR and cochlear reflectance. The modeling work will facilitate interpretation of the measurements and provide a deeper understanding of cochlear wave-propagation, cochlear compression, and negative damping regions. Reliable estimation of CGR is clinically significant for the remediation of hearing loss because its deviation from normal provides a precise estimate of the amount of compression that an external hearing aid needs to provide. The goal of the proposed research is the development of a computational model of cochlear mechanics that will facilitate the interpretation of noninvasive measures of peripheral auditory status in humans. This work is relevant to public-health because people with hearing loss not only have problems hearing soft sounds, they also experience sounds growing louder too quickly. Understanding how the sense organ of hearing (the cochlea) influences the growth of loudness should provide useful information for the design of hearing aids tailored to individual needs.

描述（由申请人提供）：本研究计划的重点是理论和经验研究，这些研究涉及与无创力相关的人工耳蜗功能评估的人工耳蜗机制中的当前问题。这些研究的主要目标是了解耳蜗波传播并表征人工耳蜗。这些目标是通过六个具体目标实现的。前三个目的是通过建模努力针对以下理论问题的建模工作来关注人工耳蜗传播的各个方面：（1）适当的人工耳蜗增益的表征； （2）对失真产物逆行波传播的更完整理解； （3）理解基底膜测量中缺口的机制。接下来的三个目标是通过涉及人类受试者的经验研究和涉及人工耳蜗模型的理论工作的结合来表征人工耳蜗压缩的生长。具体而言，这三项研究旨在提高我们对：（4）压缩生长速率（CGR）和前向掩盖心理测量功能的斜率的理解； （5）CGR和抑制增长率； （6）CGR和人工耳蜗。建模工作将促进对测量结果的解释，并更深入地理解耳蜗波 - 刺激，耳蜗压缩和负阻尼区域。可靠的CGR估计对于补救听力损失具有临床意义，因为其与正常的偏差提供了对外部助听器需要提供的压缩量的精确估计。拟议的研究的目的是开发人工耳蜗的计算模型，该模型将促进人类外围听觉状况无创测量的解释。这项工作与公共卫生有关，因为有听力损失的人不仅遇到柔和的声音遇到问题，而且声音的声音也太快了。了解听力器官（耳蜗）如何影响响​​度的增长应为设计满足个人需求的助听器设计提供有用的信息。