COCHLEAR MECHANICS, WAVE PROPAGATION, AND COMPRESSION

耳蜗力学、波传播和压缩

基本信息

批准号：
10319973
负责人：
Stephen T Neely
金额：
$ 32.68万
依托单位：
FATHER FLANAGAN'S BOYS' HOME
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10319973
关键词：
Acoustic Nerve Acoustics Address Affect Amplifiers Area Auditory Auditory Threshold Auditory system Basilar Membrane Behavioral Clinical Cochlea Complex Computer Models Computer Simulation Confusion Dependence Development Diagnosis Dimensions Elements Exhibits Frequencies Functional disorder Goals Growth Hearing Hearing Aids Human Impairment Inner Hair Cells Investigation Knowledge Labyrinth Liquid substance Loudness Measurement Mechanics Methods Modeling Motion Noise Non-linear Models Organ Outer Hair Cells Pattern Perception Peripheral Physiological Process Property Recording of previous events Research Residual state Role Sensorineural Hearing Loss Signal Transduction Speech Statistical Data Interpretation Stimulus Testing base behavior measurement clinically relevant hearing impairment human data human model human subject improved innovation interest mechanical properties method development middle ear novel otoacoustic emission pressure programs relating to nervous system remediation satisfaction signal processing simulation sound theories transmission process

项目摘要

PROJECT SUMMARY/ABSTRACT COCHLEAR MECHANICS, WAVE PROPAGATION, AND COMPRESSION The proposed project continues a program of research that is improving our knowledge of cochlear function through a combination of theoretical and empirical studies of fundamental processes in the peripheral auditory system that have both basic and translational implications. The first aim addresses a theoretical issue concerning power amplification in cochlear mechanics. It posits a mechanism for amplification in a four- chamber cochlear model and investigates consistency with experimental observations. This aim tests supporting evidence for the existence of a hypothetical cochlear amplifier. The second aim focuses on further development of a method for measurement of acoustic emissions from the inner ear that are evoked by wide- band noise stimuli. Signal processing and statistical analysis of these cochlear-reflectance measurements will improve their sensitivity to hearing loss and improve the accuracy of their prediction of hearing threshold. The remaining two aims of this project both utilize a cochlear-processing simulation, which is based on an existing nonlinear model of cochlear mechanics. Through a combination of computational modeling and behavioral measurements these aims will investigate two perceptual phenomena: consonant recognition and loudness growth. These aims will both test the hypothesis that cochlear processing produces spectro-temporal features that are closer to observed perception than features derived directly from the acoustic signal. Through efforts related to all four aims, questions that possess both basic scientific interest and applied clinical relevance will be addressed by combined application of measurement and modeling efforts.

项目概要/摘要耳蜗力学、波传播和压缩拟议的项目延续了一项研究计划，旨在提高我们对人工耳蜗的了解通过对外围基本过程的理论和实证研究相结合来发挥作用具有基本和翻译意义的听觉系统。第一个目标解决理论问题关于耳蜗力学中的功率放大。它提出了一种四元放大机制腔室耳蜗模型并研究与实验观察的一致性。这个目标测试支持假设的耳蜗放大器存在的证据。第二个目标侧重于进一步开发一种测量内耳声发射的方法，这些声发射是由广泛的带状噪声刺激。这些耳蜗反射测量的信号处理和统计分析将提高他们对听力损失的敏感性并提高他们预测听力阈值的准确性。这该项目的其余两个目标均利用耳蜗处理模拟，该模拟基于现有的耳蜗力学的非线性模型。通过计算建模和行为的结合这些目标将调查两种感知现象：辅音识别和响度生长。这些目标都将检验人工耳蜗处理产生光谱时间特征的假设比直接从声学信号导出的特征更接近观察到的感知。通过努力与所有四个目标相关的问题将具有基本科学兴趣和应用临床相关性通过测量和建模工作的结合应用来解决。