COCHLEAR MECHANICS, WAVE PROPAGATION, AND COMPRESSION

耳蜗力学、波传播和压缩

基本信息

批准号：
10319973
负责人：
Stephen T Neely
金额：
$ 32.68万
依托单位：
FATHER FLANAGAN'S BOYS' HOME
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10319973
关键词：
Acoustic Nerve Acoustics Address Affect Amplifiers Area Auditory Auditory Threshold Auditory system Basilar Membrane Behavioral Clinical Cochlea Complex Computer Models Computer Simulation Confusion Dependence Development Diagnosis Dimensions Elements Exhibits Frequencies Functional disorder Goals Growth Hearing Hearing Aids Human Impairment Inner Hair Cells Investigation Knowledge Labyrinth Liquid substance Loudness Measurement Mechanics Methods Modeling Motion Noise Non-linear Models Organ Outer Hair Cells Pattern Perception Peripheral Physiological Process Property Recording of previous events Research Residual state Role Sensorineural Hearing Loss Signal Transduction Speech Statistical Data Interpretation Stimulus Testing base behavior measurement clinically relevant hearing impairment human data human model human subject improved innovation interest mechanical properties method development middle ear novel otoacoustic emission pressure programs relating to nervous system remediation satisfaction signal processing simulation sound theories transmission process

Acoustic Nerve Acoustics Address Affect Amplifiers Area Auditory Auditory Threshold Auditory system Basilar Membrane Behavioral Clinical Cochlea Complex Computer Models Computer Simulation Confusion Dependence Development Diagnosis Dimensions Elements Exhibits Frequencies Functional disorder Goals Growth Hearing Hearing Aids Human Impairment Inner Hair Cells Investigation Knowledge Labyrinth Liquid substance Loudness Measurement Mechanics Methods Modeling Motion Noise Non-linear Models Organ Outer Hair Cells Pattern Perception Peripheral Physiological Process Property Recording of previous events Research Residual state Role Sensorineural Hearing Loss Signal Transduction Speech Statistical Data Interpretation Stimulus Testing base behavior measurement clinically relevant hearing impairment human data human model human subject improved innovation interest mechanical properties method development middle ear novel otoacoustic emission pressure programs relating to nervous system remediation satisfaction signal processing simulation sound theories transmission process

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项目摘要

PROJECT SUMMARY/ABSTRACT COCHLEAR MECHANICS, WAVE PROPAGATION, AND COMPRESSION The proposed project continues a program of research that is improving our knowledge of cochlear function through a combination of theoretical and empirical studies of fundamental processes in the peripheral auditory system that have both basic and translational implications. The first aim addresses a theoretical issue concerning power amplification in cochlear mechanics. It posits a mechanism for amplification in a four- chamber cochlear model and investigates consistency with experimental observations. This aim tests supporting evidence for the existence of a hypothetical cochlear amplifier. The second aim focuses on further development of a method for measurement of acoustic emissions from the inner ear that are evoked by wide- band noise stimuli. Signal processing and statistical analysis of these cochlear-reflectance measurements will improve their sensitivity to hearing loss and improve the accuracy of their prediction of hearing threshold. The remaining two aims of this project both utilize a cochlear-processing simulation, which is based on an existing nonlinear model of cochlear mechanics. Through a combination of computational modeling and behavioral measurements these aims will investigate two perceptual phenomena: consonant recognition and loudness growth. These aims will both test the hypothesis that cochlear processing produces spectro-temporal features that are closer to observed perception than features derived directly from the acoustic signal. Through efforts related to all four aims, questions that possess both basic scientific interest and applied clinical relevance will be addressed by combined application of measurement and modeling efforts.

项目摘要/摘要人工耳蜗，波传播和压缩拟议的项目继续进行一项研究计划，以提高我们对人工耳蜗的了解通过对周围基本过程的理论和经验研究的结合来功能具有基本和翻译含义的听觉系统。第一个目的解决了理论问题关于耳蜗力学中的功率扩增。它提出了在四个 - 腔室耳蜗模型并研究了与实验观测的一致性。此目标测试支持存在假设的耳蜗放大器的证据。第二个目标重点是进一步开发一种测量内耳的声学排放的方法，该方法被广泛引起带噪声刺激。这些耳蜗反射测量的信号处理和统计分析将提高他们对听力损失的敏感性，并提高其听力阈值预测的准确性。这该项目的剩余两个目标既利用了人工耳蜗，这是基于现有的人工耳蜗的非线性模型。通过计算建模和行为的结合测量这些目标将研究两种感知现象：辅音认可和响度生长。这些目标都将测试人工耳蜗产生光谱特征的假设比直接从声学信号得出的特征更接近观察到的感知。通过努力与所有四个目标相关，具有基本科学兴趣和应用临床相关性的问题将会通过合并的测量和建模工作来解决。