Neural Signatures of Enhanced Central Auditory Gain in Hyperacusis

听觉过敏中枢听觉增益增强的神经特征

• 批准号: 10285833
• 负责人: Kelly Nicole Jahn
• 金额: $ 4.6万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10285833
• 关键词: Acoustic Nerve; Acoustics; Address; Adverse reactions; Affective; Age; Animal Model; Area; Arousal; Auditory; Auditory Threshold; Auditory system; Behavioral; Biological Assay; Biological Markers; Caliber; Clinical; Clinical Research; Code; Development; Diagnosis; Diagnostic; Disease; Distress; Ear; Electroencephalography; Electrophysiology (science); Emotional; Employment; Exhibits; Eye; Face; Fright; Functional disorder; Galvanic Skin Response; General Population; Goals; Growth; Hearing; Hearing problem; Heart Rate; Heterogeneity; Hyperactivity; Hyperacusis; Hypersensitivity; Individual; Injury; Intervention; Investigation; K-Series Research Career Programs; Laboratories; Lead; Libraries; Limbic System; Link; Loudness; Loudness Perception; Maps; Massachusetts; Measures; Mentored Research Scientist Development Award; Mentors; Mentorship; Methods; Monitor; Movement; Mus; Negative Valence; Neuraxis; Output; Pain; Patient Self-Report; Patients; Perception; Peripheral; Physiological; Plant Roots; Prevalence; Psychoacoustics; Psychophysics; Pupil; Quality of life; Questionnaires; Reflex action; Reporting; Research; Scientist; Secondary to; Social isolation; Stimulus; Symptoms; Testing; Training; accurate diagnosis; associated symptom; auditory pathway; avoidance behavior; behavior measurement; clinical diagnostics; comorbidity; deafness; effective therapy; emotional distress; hearing impairment; human model; human subject; negative affect; neurophysiology; normal hearing; psychosocial; relating to nervous system; response; social; sound; tool

PROJECT SUMMARY/ABSTRACT Hyperacusis is a common and debilitating auditory disorder wherein sounds of moderate intensity are described as unbearably loud, aversive, or even painful. Hyperacusis often has a profoundly negative impact on quality of life, leading to loss of employment, social isolation, and severe psychiatric co-morbidities. Despite the prevalence and heterogeneity of self-reported auditory and emotional sequelae secondary to hyperacusis, its characterization remains largely qualitative. Clinicians lack quantitative and objective neurophysiological markers that would illuminate the neural basis for hyperacusis and allow accurate diagnosis and surveillance of psychoacoustic and distress-related symptoms. In this mentored career development award, the Candidate proposes a training plan to develop objective, non-invasive physiological biomarkers that can quantitatively dissociate complaints of enhanced loudness perception and sound-evoked distress in individuals with hyperacusis, and which have the potential to evolve into a new class of clinical diagnostic tools for evaluating sound intolerance. Supported by decades of research on acoustic injury in animal models, we posit that many of the sound intolerance symptoms associated with hyperacusis share a common root related to maladaptive hyperexcitability (i.e., increased gain) in the central auditory and limbic systems. In Aim 1, the Candidate will implement a battery of perceptual and electroencephalography (EEG) measures to test the hypothesis that subjects with hyperacusis have steeper electrophysiological sound-level growth in the central auditory system and heightened loudness perception as compared to age-matched neurotypical controls. In Aim 2, the Candidate will use complementary behavioral and objective measures of arousal and affective sound quality to test the hypothesis that individuals with hyperacusis exhibit greater subjective and physiological sound-evoked arousal (i.e., larger changes in pupil diameter, skin conductance, heart rate, and facial micro-movements) for emotionally neutral stimuli than age-matched neurotypical controls. The Candidate has assembled a mentorship team of world-class clinicians and auditory neuroscientists that have expertise in a range of relevant areas for the proposal including electrophysiological and psychophysical measures of central gain in humans and animal models. The Eaton-Peabody Laboratories at Massachusetts Eye and Ear is the world’s leading center for the study of hearing and deafness, allowing ample opportunities for research and professional development. The K01 award will allow the Candidate to reshape the reach and sophistication of the clinical research questions that she can pursue, providing a crucial stepping-stone toward her goal of developing into an independent clinician-scientist.

项目摘要/摘要 Hyper Acusis是一种常见且令人衰弱的听觉障碍，其中描述了中等强度的声音 令人难以置信的响亮，厌恶甚至痛苦。 Hyper Acusis通常对质量产生深远的负面影响 生活，导致失业，社会隔离和严重的精神病合并症。尽管流行 自我报告的听觉和情感后遗症的异质性继发于Hypersis，它 表征在很大程度上仍然是定性的。临床医生缺乏定量和客观的神经生理学 标记可以阐明神经基础的神经基础，并允许准确的诊断和监视 精神声音和与遇险有关的符号。在这个事业发展奖中，候选人 提案制定培训计划，以制定客观的非侵入性物理生物标志物，可以定量 解除对具有增强的响度感知和声音诱发的人的抱怨 Hyper Acusis，它们有可能发展为一类新的临床诊断工具来评估 声音intlerance。在动物模型中数十年来关于声学损伤的研究的支持下，我们肯定了许多 与超丘脑有关 中央听觉和边缘系统中的过度兴奋性（即增加增益）。在AIM 1中，候选人将 实施一系列感知和脑电图（EEG）的措施，以检验以下假设 HyperSusis的受试者在中央听觉系统中具有钢铁的电生理声音水平增长 与年龄匹配的神经型对照相比，响度的增强感。在AIM 2中，候选人 将使用唤醒和情感音质的完整行为和客观测量来测试 假设患有超源的人暴露了更大的主观和物理声音诱发的唤醒 （即，瞳孔直径，皮肤电导，心率和面部微动物的更大变化）在情感上 中性刺激比年龄匹配的神经型对照。候选人组建了一个心态团队 世界一流的临床医生和听觉神经科学家在一系列相关领域具有专业知识 提案，包括人类和动物中心收益的电生理和心理物理测量 型号。马萨诸塞州Eye and Ear的Eaton-Peabody Laboratories是世界领先的领先中心 听力和死亡的研究，为研究和专业发展提供了充足的机会。 K01奖将使候选人能够重塑临床研究问题的影响力和复杂性 她可以追求，为她发展成为独立的目标提供了至关重要的垫脚石 临床科学家。