Cochlear Mechanics, Wave Propagation, and Compression

耳蜗力学、波传播和压缩

• 批准号: 8501937
• 负责人: Stephen T Neely
• 金额: $ 33.64万
• 依托单位: FATHER FLANAGAN'S BOYS' HOME
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8501937
• 关键词: Accounting; Address; Affect; Area; Auditory Brainstem Responses; Cochlea; Cochlear Hearing Loss; Complex; Dependence; Distant; Ear; Frequencies; Generations; Goals; Growth; Hearing Aids; Human; Intervention; Knowledge; Labyrinth; Masks; Measurement; Measures; Mechanics; Methods; Modeling; Noise; Pattern; Phase; Process; Property; Psychophysics; Research; Signal Transduction; Source; Stimulus; Testing; Time; Travel; Work; base; clinically relevant; computerized data processing; hearing impairment; human subject; improved; insight; interest; mathematical model; otoacoustic emission; pressure; programs; public health relevance; response; simulation; sound; tool

DESCRIPTION (provided by applicant): The proposed program of research will increase our knowledge of cochlear function through a combination of theoretical and empirical studies addressing fundamental processes in ways that have both basic and translational implications. The program focuses on two interrelated areas: (1) the level-dependence of cochlear delays and (2) the effect on cochlear response growth at a particular frequency due to the presence of suppressors at other frequencies. Suppression and level-dependent latency share a common mechanism that is primarily responsible for cochlear compression. These areas represent features of normal cochlear function that are affected by cochlear hearing loss and potentially may be remediated by external hearing aids that incorporate sophisticated signal-processing strategies. The first two Aims of the proposal are to further understand (1) cochlear-reflectance generation and (2) the latency and masking of cochlear transients. Cochlear reflectance is defined as a transfer function between pressure waves entering and exiting the cochlea, and has advantages over other measures of cochlear responses. The remaining Aims are to determine the influence of (3) high-frequency suppression on cochlear distortion generators and (4) low- frequency suppression on cochlear compression. Through the work related to these four Aims, questions that possess both basic scientific interest and applied clinical relevance wil be answered by combined application of measurement and modeling efforts.

描述（由申请人提供）：拟议的研究计划将通过理论和实证研究相结合，以具有基本和转化意义的方式解决基本过程，从而增加我们对耳蜗功能的了解。该计划重点关注两个相互关联的领域：（1）耳蜗延迟的水平依赖性；（2）由于其他频率存在抑制器而对特定频率的耳蜗响应增长的影响。抑制和电平相关的延迟共享一个主要负责耳蜗压缩的共同机制。这些区域代表了正常耳蜗功能的特征，这些特征受到耳蜗听力损失的影响，并且可能可以通过包含复杂信号处理策略的外部助听器进行修复。该提案的前两个目标是进一步了解 (1) 耳蜗反射率的生成和 (2) 耳蜗瞬变的延迟和掩蔽。耳蜗反射率被定义为进入和离开耳蜗的压力波之间的传递函数，并且比其他耳蜗响应测量具有优势。其余目标是确定 (3) 高频抑制对耳蜗失真发生器的影响以及 (4) 低频抑制对耳蜗压缩的影响。通过与这四个目标相关的工作，具有基本科学兴趣和应用临床相关性的问题将通过测量和建模工作的结合应用得到解答。