Influence of subglottic anatomy on voice production

声门下解剖结构对发声的影响

• 批准号: 8094310
• 负责人: SCOTT L THOMSON
• 金额: $ 33.64万
• 依托单位: BRIGHAM YOUNG UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8094310
• 关键词: Acoustics; Adult; Affect; Aftercare; Anatomy; Area; Caring; Characteristics; Computer Simulation; Connective Tissue; Coupling; Data; Excision; Experimental Models; Female; Frequencies; Goals; Healed; Health; Image; Imagery; Intervention; Larynx; Lead; Life; Measures; Mechanics; Medical; Modeling; Motion; Motivation; Muscle; Operative Surgical Procedures; Outcome; Paralysed; Patients; Phonation; Positioning Attribute; Postoperative Period; Procedures; Production; Prostheses and Implants; Research; Research Personnel; Resolution; Role; Simulate; Slice; Source; Speech; Stenosis; Stress; Subglottis structure; Testing; Tissues; Voice; Voice Disorders; Voice Quality; X-Ray Computed Tomography; clinical care; conditioning; design; glottis; healing; improved; male; model development; models and simulation; physical model; pressure; reconstruction; repository; research study; routine care; sound frequency; vibration; virtual; vocal cord

DESCRIPTION (provided by applicant): Vocal fold vibration is caused by a three-way coupling between laryngeal aerodynamics, acoustics, and tissue dynamics. Research focused on the glottic and supraglottic laryngeal regions has led to improved clinical care and medical procedures. Less understood is the role of the subglottic region in vocal fold vibration. However, the subglottis is an important part of speech production. A clear understanding of the geometry and mechanics of the subglottis will show how vocal fold vibration is affected by adverse conditions, such as subglottic stenosis, and corresponding phonosurgical treatment procedures. The goal of the proposed research is to acquire an improved understanding of the role of subglottic anatomy in voice production. This will result from pursuit of the following specific aims: Aim 1: Quantify three-dimensional adult human larynx geometry for use in voice production research. High-resolution, spatially calibrated images of adult human larynges will be collected from computed tomography (CT) and histological image sequences. Micro-CT and histological images will be obtained using excised larynges. These will be used to quantify macroscale glottic and subglottic geometric definitions, including vocal folds, cartilaginous framework, muscles, and connective tissue. The data will be made freely available to other researchers through an on-line repository. Aim 2: Explore the influence of subglottic anatomy on structural, acoustic, and aerodynamic aspects of phonation using complementary synthetic and computational models. Geometric data from Aim 1 will be used to create synthetic and computational self-oscillating laryngeal models, including glottic and subglottic regions. Models with changes in subglottic geometry and composition will be created, tested, and compared with original models. Observables include structural, acoustic, and aerodynamic data. Aim 3: Simulate the results of phonosurgical intervention through computational and synthetic model reconstruction. Patients with subglottic stenosis have CT imaging studies of the larynx available as part of their routine care. Before and after phonosurgical procedure of cricotracheal sleeve resection, the larynx will again be imaged. The images will be used for computational and synthetic model simulation and analysis. The results will be compared with preoperative and postoperative acoustic, aerodynamic, and laryngeal imaging measures. Adjustments to improve phonation will be tested using the computational and physical models. Accomplishing the above aims will impact several areas of voice care and research, including surgical treatment of voice disorders, vocal fold prosthesis and implant design, and voice production research. PUBLIC HEALTH RELEVANCE: The subglottis is an important part of speech production. Voice disorders such as unilateral vocal fold paralysis and subglottic stenosis affect the subglottic region and often require surgical intervention. The goal of the proposed research is to improve our understanding of the role of the subglottis in voice production and to use this understanding to refine and improve real-life phonosurgical procedures.

描述（由申请人提供）：声带振动是由喉空气动力学，声学和组织动力学之间的三路耦合引起的。研究的研究重点是发光和喉部喉部地区，导致了改善的临床护理和医疗程序。不了解的是次声门区域在声带振动中的作用。但是，次洛蒂斯是语音生产的重要组成部分。对次数的几何形状和力学有清晰的了解将表明声带振动如何受到不利条件的影响，例如亚平原狭窄，以及相应的语音外科治疗程序。拟议的研究的目的是提高人们对次声学解剖学在语音生产中的作用的了解。这将源于追求以下特定目标：目标1：量化用于语音生产研究的三维成年人喉几何形状。将从计算机断层扫描（CT）和组织学图像序列中收集成人人喉的高分辨率，空间校准的图像。将使用切除的喉部获得微CT和组织学图像。这些将用于量化宏观镜头的镜头和次宽几何定义，包括人声褶皱，软骨框架，肌肉和结缔组织。数据将通过在线存储库免费提供给其他研究人员。 AIM 2：使用互补的合成模型和计算模型探讨次声底解剖对发音的结构，声学和空气动力学方面的影响。来自AIM 1的几何数据将用于创建合成和计算自我振荡的喉模型，包括震颤和宽整个区域。将创建，测试并与原始模型进行比较的模型，并与原始几何形状和构图发生变化。可观察的内容包括结构，声学和空气动力学数据。 AIM 3：通过计算和合成模型重建模拟声外科干预的结果。次变狭窄的患者对喉部进行CT成像研究，作为其常规护理的一部分。在骨气阀切除术的语音外科手术程序之前和之后，将再次成像喉部。这些图像将用于计算和合成模型仿真和分析。结果将与术前和术后声学，空气动力学和喉部成像措施进行比较。调整以改进发声将使用计算和物理模型进行测试。实现上述目标将影响语音护理和研究的几个领域，包括对语音疾病的外科手术治疗，声带假体和植入物设计以及语音生产研究。公共卫生相关性：次洛蒂斯是语音生产的重要组成部分。语音疾病，例如单方面声折叠瘫痪和次变狭窄，会影响下整个区域，并且通常需要手术干预。拟议的研究的目的是提高我们对sublottis在语音生产中的作用的理解，并利用这种理解来完善和改善现实生活中的声音外科程序。