Imaging and influence of glottic and subglottic anatomy in healthy and stenotic patients

健康和狭窄患者声门和声门下解剖结构的成像和影响

• 批准号: 10239212
• 负责人: SCOTT L THOMSON
• 金额: $ 59.42万
• 依托单位: BRIGHAM YOUNG UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10239212
• 关键词: 3-Dimensional; 3D Print; Acoustics; Adoption; Anatomy; Breathing; Cataloging; Characteristics; Child; Clinical; Clinical Protocols; Communication; Computer Simulation; Custom; Data; Data Analyses; Development; Dysphonia; Evaluation; Excision; Geometry; Image; Image Analysis; Impairment; Ionizing radiation; Laboratory Study; Larynx; Literature; Magnetic Resonance Imaging; Medical Imaging; Methodological Studies; Modeling; Morphology; Nature; Noise; Operative Surgical Procedures; Outcome; Patient-Focused Outcomes; Patients; Pattern; Performance at work; Phonation; Population; Positioning Attribute; Postoperative Period; Procedures; Protocols documentation; Quality of life; Radiation exposure; Research; Resolution; Scanning; Scientist; Severities; Signal Transduction; Source; Stenosis; Structure; Structure-Activity Relationship; Surgical Management; Testing; Time; Variant; Voice; Voice Disorders; Voice Quality; Woman; Work; X-Ray Computed Tomography; base; clinical development; data repository; design; imaging capabilities; imaging modality; improved; in vivo; insight; laboratory experiment; preservation; prospective; prototype; psychosocial; public repository; research clinical testing; surgery outcome; three-dimensional modeling; tool; treatment research; vibration; vocal cord

SUMMARY Upper airway stenosis is a condition that significantly impairs breathing and voice. Stenosis-related voice disorders can adversely impact communication, job performance, psychosocial function, and quality of life. Clinical and scientific studies have elucidated important relationships between voice function and stenosis severity and management, but many aspects of these relationships are not fully understood. The objectives of the proposed research are to develop larynx-specific MRI coils and protocols for upper airway stenosis imaging and to determine the impact of glottic and subglottic morphology on voice function in upper airway stenosis patients. Custom imaging coils and protocols will be developed and refined based on physical principles and preliminary tests. MR images in stenosis patients will be acquired pre- and post-operatively. Images will be used to create 3D geometric models for morphometric analysis and posting on an online laryngeal data repository for further research. Retrospective and prospective pre- and post-operative aerodynamic and acoustic studies of patients with upper airway stenosis will be conducted to explore relationships between preoperative voice complaints and pre/post-operative voice changes. Excised larynx and synthetic vocal fold laboratory experiments using 3D-printed airways with adjustable stenoses, in conjunction with complementary computational simulations of phonatory flow-structure-acoustic interactions, will be used to explore fundamental physical relationships between stenosis geometry and changes in flow patterns, vocal fold vibration, and acoustics. Anticipated outcomes include larynx imaging coil prototypes and protocols suitable for the needs of clinical laryngeal imaging evaluations and scientific research, detailed geometric three-dimensional models of the upper airway in healthy and stenosis populations, and deeper insight into the sources of dysphonia in stenosis patients and into the aerodynamic and acoustical changes associated with upper airway stenosis. The ultimate aim is to develop tools and understanding that will lead to improved voice outcomes for patients with upper airway stenosis.

概括 上气道狭窄是一种严重损害呼吸和声音的疾病。与狭窄有关的声音 疾病会对沟通，工作绩效，社会心理功能和生活质量产生不利影响。 临床和科学研究阐明了语音功能与狭窄之间的重要关系 严重性和管理，但是这些关系的许多方面尚未完全理解。目标的目标 拟议的研究是开发针对上气道狭窄成像的喉特异性MRI线圈和协议 并确定光门和次听力形态对上呼吸道狭窄中语音功能的影响 患者。自定义成像线圈和协议将根据物理原理制定和完善 初步测试。狭窄患者的MR图像将在术前和术后获得。图像将被使用 创建用于形态分析的3D几何模型，并在在线喉数据存储库上发布 进一步的研究。回顾性和前瞻性前后的术前和术后空气动力学和声学研究 将进行上呼吸道狭窄的患者，以探索术前声音之间的关系 投诉和术前/术后的声音发生变化。切除的喉部和合成声折叠实验室实验 与互补的计算模拟一起，使用3D打印的气道带有可调节的伸卵 语音流程结构 - 声学相互作用将用于探索基本的物理关系 在狭窄几何形状和流动模式，声带振动和声学之间的变化之间。预期 结果包括喉成像线圈原型和适合临床喉成像需求的方案 评估和科学研究，上呼吸道的详细几何三维模型 和狭窄种群，以及对狭窄患者烦躁不安的来源的更深入的了解 与上气道狭窄相关的空气动力学和声学变化。最终目的是开发工具 并了解这将导致上呼吸道狭窄患者的语音结果改善。