Influence of surface adhesion forces on vocal fold stress and function

表面粘附力对声带应力和功能的影响

• 批准号: 7850320
• 负责人: SCOTT L THOMSON
• 金额: $ 4.2万
• 依托单位: BRIGHAM YOUNG UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7850320
• 关键词: Adhesions; Adhesives; Area; Awareness; Behavior; Caring; Data; Dehydration; Development; Elements; Frequencies; Goals; Human; Individual; Lead; Liquid substance; Medical; Modeling; Mono-S; Mucous body substance; Phonation; Procedures; Production; Property; Prostheses and Implants; Research; Research Project Grants; Source; Stress; Study models; Surface; Thick; Tissue Engineering; Tissues; Voice; Voice Disorders; airway surface liquid; clinical care; design; improved; pressure; research study; respiratory; two-dimensional; vibration; vocal cord

DESCRIPTION (provided by applicant): Stress within vocal fold tissue is a primary source of vocal fold discomfort and damage. Identifying the influence of various factors that contribute to vocal fold stress can lead to improved clinical care, improved medical procedures, and increased awareness of individuals in the workforce who rely on voice use. One source of vocal fold stress is that which results from increased adhesive properties of the glottal airway surface liquid (ASL). Such situations can arise, for example, from dehydration. The goal of the proposed research is to develop models for studying the glottal ASL and use these models to explore the sensitivity of vocal fold stress and function to ASL adhesion forces. Pursuit of this goal is planned through the use of complementary analytical, synthetic, and computational vocal fold models according to the following research aims: Specific Aim 1: Develop airway surface liquid models for use in computational vocal fold models. Develop analytical and computational (finite element) models of glottal airway surface liquid (ASL). Incorporate two- layer ASL representation, namely, Newtonian sol layer and non-Newtonian mucus layer. Validate models with experiments carried out using mono- and bi-layer Newtonian and non-Newtonian fluids, including sol and mucus simulants. Specific Aim 2: Incorporate airway surface liquid models in self-oscillating computational vocal fold models. Incorporate ASL models into self-oscillating models of vocal fold vibration, including a two-dimensional, body- cover finite element (FE) vocal fold model and a three-dimensional, multi-tissue-layer FE vocal fold model. Validate models with data from experiments using synthetic self-oscillating vocal fold models. Specific Aim 3: Investigate sensitivity of vocal fold stress and function during phonation to airway surface liquid properties using computational vocal fold models. Using the FE vocal fold + ASL models (Specific Aim 2), identify conditions in which ASL adhesion forces become sufficiently large so as to significantly influence vocal fold stress and function. Perform parametric sensitivity studies using different values of ASL thickness and properties, vocal fold tissue layer geometry and properties, and oscillation parameters. Observables include stress within the vocal fold cover, oscillation frequency and amplitude, open quotient, glottal airflow waveforms, and frequency vs. pressure and flow rate vs. pressure relationships. Accomplishing the above aims will impact several areas of voice care and research, including: engineered tissue development for replacing damaged vocal fold tissue, vocal fold prosthesis and implant design, voice disorder treatment, and voice production research. Project Narrative: The airway surface liquid (ASL) lines the human respiratory airways. Under certain conditions the glottal ASL is subject to dehydration and other property changes that may adversely influence voice production. The objective of the proposed research is to develop models of the glottal ASL and explore its influence on vocal fold tissue stress and vibratory behavior.

描述（由申请人提供）：声带组织中的压力是声带不适和损害的主要来源。确定导致声带压力的各种因素的影响可以改善临床护理，改善医疗程序，并提高依靠语音使用的劳动力中个人的认识。声带应力的一种来源是，它是由于Glottal气道表面液体（ASL）的粘附性能增加而产生的。例如，这种情况可能是由于脱水而产生的。拟议的研究的目的是开发用于研究震颤ASL的模型，并使用这些模型探索声带应力和功能对ASL粘附力的敏感性。根据以下研究目的，使用互补的分析，合成和计算人声折叠模型来计划实现此目标的追求：特定目的1：开发气道表面液体模型以用于计算人声折叠模型。开发glottal气道表面液体（ASL）的分析和计算（有限元）模型。结合两层ASL表示形式，即牛顿溶胶层和非牛顿粘液层。使用单层牛顿和非牛顿液（包括溶胶和粘液模拟物）进行的实验验证模型。特定目的2：将气道表面液体模型纳入自我振荡的计算声折叠模型。将ASL模型纳入声带振动的自动振荡模型中，包括二维，身体覆盖有限元（Fe）人声折叠模型和三维，多组织的FE人声折叠模型。使用合成自我振荡的人声折叠模型从实验中验证模型。特定目的3：使用计算声折型模型调查发声期间声带应力和功能对气道表面液体性质的敏感性。使用Fe人声折叠 + ASL模型（特定目标2），确定ASL粘附力变得足够大的条件，以显着影响声带应力和功能。使用ASL厚度和性质的不同值，声带折叠组织层几何形状和性能以及振荡参数进行参数灵敏度研究。可观察的物品包括在声带盖内的压力，振荡频率和振幅，开放式商，气流气流波形以及频率与压力和流量与压力关系的频率与压力关系。完成上述目标将影响语音护理和研究的几个领域，包括：工程组织开发，用于替换受损的声带组织，声带折叠假体和植入物设计，语音障碍处理和语音生产研究。 项目叙述：气道表面液体（ASL）在人呼吸道气道上排列。在某些条件下，震颤ASL会受到脱水和其他可能影响语音产生的特性变化。拟议的研究的目的是开发glottal ASL的模型，并探索其对声带组织应力和振动行为的影响。