CENTER FOR MOLECULAR, CELLULAR, AND TRANSLATIONAL IMMUNOLOGY

分子、细胞和翻译免疫学中心

• 批准号: 8364912
• 负责人: WILLIAM R GREEN
• 金额: $ 118.5万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364912
• 关键词: Award; Basic Science; Biology; Centers of Research Excellence; Development; Faculty; Foundations; Funding; Goals; Grant; Human; Immunology; Investigation; Lung; Medical center; Mentors; Molecular; National Center for Research Resources; Norris Cotton Cancer Center; Phase; Pilot Projects; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Services; Source; United States National Institutes of Health; Universities; Vermont; base; bench to bedside; cost; medical schools; programs; success; systems research; translational approach

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Based on the success of the initial 10-year award, the ultimate goals of this COBRE renewal application are to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and Translational Immunological Research, and to transition this COBRE Center for Immunological Research (COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five years. With the foundation of a long-standing Immunology Program, which has now been substantially enhanced by COBRE support, this proposal takes advantage of a highly interactive core of collaborative faculty at Dartmouth Medical School (DMS) and Dartmouth Hitchcock Medical Center (DHMC). With this expanded investigator base, a Phase III COBRE award will provide the resources to build the needed infrastructure to sustain the COBRE-CIR, further grow the Program, and facilitate inter-disciplinary basic science to translational immunological research. This infrastructure will include the continued mentored development of our immunological faculty, especially those investigators previously supported by COBRE; expansion of the COBRE Cores and their full integration with existing complementary cores and shared services at DMS/DHMC, particularly the Norris Cotton Cancer Center and the other Immunology and "Lung Biology" COBREs at Dartmouth and the University of Vermont; and an enhanced Pilot Project Program with targeting to mentored, collaborative, and/or translational/human systems research. Together with substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of investigators, already expanded and matured by the COBRE mechanism, can be further developed to complete the formation of a sustainable Center for Immunological Research that is grounded in excellent basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside application of hypothesis-driven research, and has a regional, if not also national, impact.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 DESCRIPTION (provided by applicant): Based on the success of the initial 10-year award, the ultimate goals of this COBRE renewal application are to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and Translational Immunological Research, and to transition this COBRE Center for Immunological Research (COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five years.凭借长期存在的免疫学计划的基础，该计划已通过COBRE支持大大增强，该提案利用了达特茅斯医学院（DMS）和达特茅斯希区柯克医疗中心（DHMC）的高度互动互动核心。借助扩大的研究者基础，III期COBRE奖将为建立所需的基础设施提供资源，以维持鞋底CIR，进一步发展该计划，并促进跨学科的基础科学，从而转化免疫学研究。这种基础设施将包括我们免疫学教师的持续指导发展，尤其是那些先前在科布雷支持的调查人员中；在DMS/DHMC（尤其是诺里斯棉花癌中心）和其他免疫学和其他免疫学和“肺部生物学”大约COBRES的DMS/DHMC的现有互补核心和共享服务的全面整合，并在达特茅斯大学和佛蒙特大学的“肺生物学”大约COBRES上扩展；以及一项增强的试点项目计划，其针对指导，协作和/或翻译/人类系统研究。 Together with substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of investigators, already expanded and matured by the COBRE mechanism, can be further developed to complete the formation of a sustainable Center for Immunological Research that is grounded in excellent basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside application of hypothesis-driven research, and has a regional, if not also national, 影响。