Center for Molecular, Cellular, and Translational Immunology

分子、细胞和转化免疫学中心

• 批准号: 8256739
• 负责人: WILLIAM R GREEN
• 金额: $ 118.21万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8256739
• 关键词: Antigens; Autoimmunity; Award; Basic Science; Biology; Biomedical Research; Centers of Research Excellence; Characteristics; Commit; Communicable Diseases; Consultations; Core Facility; Development; Disease; Doctor of Medicine; Doctor of Philosophy; Education; Ensure; Faculty; Flow Cytometry Shared Resource; Foundations; Funding; Goals; Human; Hypersensitivity; Immune response; Immune system; Immunologic Monitoring; Immunology; Infection; Inflammation; Institutes; Instruction; Investigation; Laboratories; Lung; Malignant Neoplasms; Medical center; Mentors; Mission; Molecular; Mus; National Center for Research Resources; National Institute of Allergy and Infectious Disease; Natural Immunity; Norris Cotton Cancer Center; Patient Care; Phase; Pilot Projects; Qualifying; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Services; Speed; Syndrome; Technology; Transgenic Organisms; United States National Institutes of Health; Universities; Vaccines; Vermont; base; bench to bedside; career; catalyst; congenic; immunopathology; medical schools; microbial; operation; programs; response; success; systems research; translational approach; tumor

Based on the success ofthe initial 10-year award, the ultimate goals of this COBRE renewal application are to complete the establishment at Dartmouth of a nationally recognized Center for Molecular, Cellular, and Translational Immunological Research, and to transition this COBRE Center for Immunological Research (COBRE-CIR) to an infrastructure-based, freestanding (from COBRE funding), sustainable center in five years. With the foundation of a long-standing Immunology Program, which has now been substantially enhanced by COBRE support, this proposal takes advantage of a highly interactive core of collaborative faculty at Dartmouth Medical School (DMS) and Dartmouth Hitchcock Medical Center (DHMC). With this expanded investigator base, a Phase III COBRE award will provide the resources to build the needed infrastructure to sustain the COBRE-CIR, further grow the Program, and facilitate inter-disciplinary basic science to translational immunological research. This infrastructure will include the continued mentored development of our immunlogical faculty, especially those investigators previously supported by COBRE; expansion ofthe COBRE Cores and their full integration with existing complementary cores and shared services at DMS/DHMC, particularly the Norris Cotton Cancer Center and the other Immunology and "Lung Biology" COBREs at Dartmouth and the Univesrity of Vermont; and an enhanced Pilot Projdect Program with targeting to mentored, collaborative, and/or translational/human systems research. Together with substantive Institutional commitment by DMS/DHMC, there is confidence that the strong existing cadre of investigators, already expanded and matured by the COBRE mechanism, can be further developed to complete the formation of a sustainable Center for Immunological Research that is grounded in excellent basic science investigation, embraces a translational approach to promote bidirectional bench-to-bedside application of hypothesis-driven research, and has a regional, if not also national, impact.

基于最初的10年奖励的成功，此cobre更新申请的最终目标是 在达特茅斯（Dartmouth）建立一个全国公认的分子，细胞和 转化免疫研究，并过渡这个毛病免疫研究中心 （COBRE-CIR）到基于基础设施的自由主义（来自柯布尔资金），可持续中心五个 年。凭借长期存在的免疫学计划的基础 通过COBRE支持增强，该建议利用了高度互动的协作核心 达特茅斯医学院（DMS）和达特茅斯希区柯克医学中心（DHMC）的教师。与此 扩大的研究者基础，III期鞋带奖将为建立所需的资源提供资源 基础设施以维持鞋底，进一步发展计划并促进跨学科基本 科学转化免疫学研究。该基础设施将包括持续的指导 开发我们的免疫教师，特别是那些先前在科布雷支持的研究人员； 扩展毛核的扩展及其与现有互补核的完整整合并共享 DMS/DHMC的服务，尤其是诺里斯棉花癌中心和其他免疫学和“肺 生物学“达特茅斯和佛蒙特州的Univerile的Cobres；以及增强的飞行员Projdect计划 针对指导，协作和/或翻译/人类系统研究的定位。一起 DMS/DHMC实质性的机构承诺，有信心，有强大的现有干部 研究人员已经扩大并已被鞋底机制扩展和成熟，可以进一步开发 完成以优秀为基础的可持续免疫研究中心的形成 基础科学调查，采用了一种转化方法来促进双向基准对床边 采用假设驱动的研究，并具有区域性（即使不是民族）的影响。