Bioinformatics and Genomics Core

生物信息学和基因组学核心

• 批准号: 10436191
• 负责人: WILLIAM R GREEN
• 金额: $ 25.18万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10436191
• 关键词: Address; Bioinformatics; Biology; Biomedical Research; Cancer Education Grant Program; Collaborations; Data; Data Analyses; Data Science; Development; Education; Educational Curriculum; Ensure; Evaluation; Evolution; Experimental Designs; FAIR principles; Faculty; Fostering; Funding; Future; Generations; Genomics; Geographic Locations; Goals; Grant; Institution; Kansas; Lead; Measures; Methods; New Hampshire; Phase; Publications; Reproducibility; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Science; Strategic Planning; Teacher Professional Development; Trainers Training; Training; Training Activity; Training Programs; Training Support; Training and Infrastructure; United States National Institutes of Health; Universities; Workforce Development; computer infrastructure; cost effective; experience; improved; informatics training; innovation; programs; skills; student training; success; undergraduate student

III. Bioinformatics and Genomics Core Abstract The overall goal of the NH-INBRE Bioinformatics and Genomics Core (BGC) is to overcome the gap in bioinformatics expertise by direct support of ongoing and new research projects and fostering integration of bioinformatics into the undergraduate curriculum. The need for support for research projects at Partner and Lead institutions extends through all phases from experimental design to publication. This includes access to state-of-the-art computational infrastructure supported by the NH-INBRE. To address the long-term goals for broad workforce training in bioinformatics, we have developed a set of resources to support core bioinformatics training in the context of a biology curriculum. In the next phase of our NH-INBRE BGC, we propose to expand both the scope of bioinformatics research support and implementation of these curriculum modules both within New Hampshire and nationally by leveraging the participation of the nationwide IDeA network. Finally, we intend to further extend this curriculum support and integrate an important focus on rigor and transparency in bioinformatics. To accomplish these goals, we have three specific aims: Aim 1: Improve the biomedical research capacity of the State of New Hampshire at the eight primarily undergraduate institutions and the two Lead universities of the NH-INBRE by: a) Supporting NH-INBRE research projects and enhancing bioinformatics expertise across the network through training in diverse bioinformatics applications; b) Providing sustainable, accessible, cost-effective, and well-managed computational infrastructure for data analysis, storage, and dissemination. Aim 2: Create a sustainable, scalable, and impactful mechanism for bioinformatics training by continuing to support the integration of bioinformatics into the undergraduate science curriculum. . For this funding period, we propose to extend this curricular support program to at least four additional INBRE Bioinformatics Cores in each of the four IDeA geographical regions, with the long-term goal to extend across all 24 INBRE programs. Aim 3: Establish workforce development training and infrastructure for advancement of Rigor and Reproducibility in bioinformatics by a) Promoting transparency of bioinformatics analysis and b) Establishing best practices for accurately presenting data and methods for INBRE-funded research. Achieving these goals will support the development of key skills and rigorous practices in line with the overarching goals as defined in the NIH strategic plan for data science. In particular, our training and support enforces the FAIR principles where data and analysis should be Findable, Accessible, Interoperable and Reusable.

iii。生物信息学和基因组学核心摘要 NH INBRE生物信息学和基因组学核心（BGC）的总体目标是克服差距 通过直接支持正在进行的新研究项目的直接支持并促进整合的生物信息学专业知识 生物信息学进入本科课程。需要支持合作伙伴的研究项目的支持 牵头机构从实验设计到出版物的所有阶段扩展。这包括访问 NH-INBRE支持的最新计算基础架构。解决长期目标 在生物信息学方面，广泛的劳动力培训，我们已经开发了一组资源来支持核心生物信息学 在生物学课程的背景下进行培训。在NH Inbre BGC的下一阶段，我们建议扩展 这些课程模块的生物信息学研究支持和实施的范围都 新罕布什尔州，在全国范围内利用全国思想网络的参与。最后，我们 打算进一步扩展该课程支持，并将重点放在严格和透明度上 生物信息学。为了实现这些目标，我们有三个具体的目标： 目标1：提高新罕布什尔州的生物医学研究能力，主要是八个 本科机构和NH-INBRE的两所主要大学作者：a）支持NH Inbre 研究项目并通过各种各样的培训来增强整个网络的生物信息学专业知识 生物信息学应用程序； b）提供可持续，易于访问，具有成本效益且管理良好的 用于数据分析，存储和传播的计算基础架构。 目标2：通过继续进行生物信息学培训的可持续，可扩展和有影响力的机制 支持将生物信息学集成到本科科学课程中。 。在此资金期间， 我们建议将此课程支持计划扩展到至少四个额外的差异生物信息学核心 四个思想地理区域中的每个区域中的每个区域都具有长期目标，以扩展所有24个INBRE计划。 目标3：建立劳动力发展培训和基础设施，以提高严格和 通过a）促进生物信息学分析的透明度和b）建立生物信息学的可重复性 准确介绍INBRE资助研究的数据和方法的最佳实践。 实现这些目标将支持关键技能和严格实践的发展 NIH数据科学战略计划中定义的总体目标。特别是我们的培训和支持 执行公平原则，在该公平原则中应找到数据和分析，可访问，可互操作以及 可重复使用的。