An Ultra High Resolution SPECT System Integrated with a High-Field MRI Scanner

与高场 MRI 扫描仪集成的超高分辨率 SPECT 系统

• 批准号: 8193606
• 负责人: Chin-Tu Chen
• 金额: $ 45.29万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8193606
• 关键词: Accounting; Address; Affect; Algorithms; Animals; Anodes; Area; Arts; Autoimmune Process; Bioluminescence; Caliber; Cathodes; CdZnTe; Cell Count; Cells; Chicago; Collimator; Contrast Media; Coupled; Custom; Detection; Development; Diabetes Mellitus; Dimensions; Electronics; Event; Fluorescence; Generations; Grant; Hemorrhage; Image; Imaging Techniques; Immunologic Monitoring; Incidence; Insulin-Dependent Diabetes Mellitus; Laboratories; Laboratory Research; Location; Magnetic Resonance Imaging; Magnetism; Medical; Metabolic; Methods; Mission; Modeling; Monitor; Mus; Non-Insulin-Dependent Diabetes Mellitus; Nuclear; Optics; Performance; Persons; Photons; Positioning Attribute; Positron-Emission Tomography; Quantitative Evaluations; Radioactivity; Radiolabeled; Research; Resolution; Signal Transduction; Stem cells; Structure of beta Cell of islet; System; T-Lymphocyte; Techniques; Thick; Time; Tissues; Transplantation; United States; Wages; Work; absorption; base; cell motility; cellular imaging; cost; design; detector; image reconstruction; imaging modality; in vivo; instrument; iron oxide; islet; light scattering; magnetic field; migration; novel; prototype; radiotracer; research study; response; single photon emission computed tomography; soft tissue; stem; tumor; ultra high resolution

DESCRIPTION (provided by applicant): In this project, we will develop a novel imaging system that combines a high-field MRI scanner and an ultrahigh resolution SPECT system for imaging metabolic and signaling targets in the pancreatic beta cell. This combined system comprises a 9.4 T 30 cm horizontal bore magnet (Oxford Instrument, Oxford, UK) with Bruker Avance Biospec (Bruker-Biospin, Billerica, MA) console equipped with 12 cm shielded gradient with maximum strength of 400mT/m, and a compact and ultrahigh resolution SPECT system that will be fitted inside the 12 cm diameter bore to allow simultaneous MR and SPECT imaging of mouse. The proposed SPECT system is based on an energy-resolved photon counting detector. It consists of pixelated CdZnTe (CZT) crystals (with 350 5m W 350 5m pitch), coupled to a custom- designed readout circuitry that utilizes an energy-resolved photon-counting (ERPC) ASIC (developed by Dr. Meng's group at UI) to readout anode pixels and the NCI-ASIC (developed by Brookhaven National Laboratory and Naval Research Laboratory) to readout the cathode signals. The ERPC detector offers (a) an ultrahigh intrinsic spatial resolution (<400 5m in all three dimensions) for 140keV 3-rays, (b) a wide dynamic range to cover 12-200keV, (c) a proven MRI- compatibility with minimized magnetic components, (d) the ability to extract signals simultaneously induced on adjacent anode pixels and the cathode, which provides critical information for correcting the event positioning error induced by the strong magnetic field, and (e) a compact form factor for packing multiple detectors into the MRI bore. The proposed imaging system combines a high-field (9.4 T) MRI scanner with an ultrahigh SPECT system. It allows an excellent co-registration of the features resolved in both MR and SPECT images. The proposed system will be applied for imaging metabolic and signaling targets in the pancreatic beta cell. The results of studies will enhance our understanding of the advantages and limitations of each imaging modality in specific models of 2cell loss and replication. PUBLIC HEALTH RELEVANCE: Type 2 diabetes mellitus (T2DM) is one of the most important medical problems of our time, with a dramatically increasing incidence affecting over 20 million persons in the United States and accounting for over $200 billion/yr in total medical costs and lost wages. New methods to treat autoimmune Type 1 diabetes would also benefit from an assessment of b-cell mass/function to monitor immune attack and possible ongoing replication as well as the fate of transplanted islets or b-cells generated from stem or other progenitor cells [9-11]. Useful, validated techniques to remains a long sought after target. In this project, we will develop a combined SPECT/MRI system that is dedicated to imaging radiolabeled cells in small lab animals. This system would offer a unique instrument for non-invasively assess b-cell mass and function in mice. We expect also that the combination of the ultrahigh resolution SPECT system and high-field MRI system would make a substantial impact to many other areas, such as in vivo tracking of radiolabeled stem cells and T cells, as well as imaging tumors in small animals.

描述（由申请人提供）：在此项目中，我们将开发一个新型的成像系统，该系统结合了高场MRI扫描仪和一个超高分辨率SPECT系统，用于成像胰腺β单元中的代谢和信号靶标。 This combined system comprises a 9.4 T 30 cm horizo​​ntal bore magnet (Oxford Instrument, Oxford, UK) with Bruker Avance Biospec (Bruker-Biospin, Billerica, MA) console equipped with 12 cm shielded gradient with maximum strength of 400mT/m, and a compact and ultrahigh resolution SPECT system that will be fitted inside the 12 cm diameter bore to allow simultaneous MR and SPECT imaging of 老鼠。拟议的SPECT系统基于能量分辨的光子计数检测器。它由像素化的CDZNTE（CZT）晶体（350 5m W 350 5m螺距）组成，并与定制设计的读数电路相结合，该电路利用能量分辨的光子计数（ERPC）ASIC（ERPC）ASIC（由UI的Meng Group）开发，由UI博士开发，以读取Anci-aver and andode andode and anci-aver and anci-aver and anci-aven and anci-aven broshav and broshav and broshaven broshav and broshav and broshaven broshav and broshav and broshav and broshav and broshaven阴极信号。 The ERPC detector offers (a) an ultrahigh intrinsic spatial resolution (<400 5m in all three dimensions) for 140keV 3-rays, (b) a wide dynamic range to cover 12-200keV, (c) a proven MRI- compatibility with minimized magnetic components, (d) the ability to extract signals simultaneously induced on adjacent anode pixels and the cathode, which provides critical information for correcting the event由强磁场引起的定位误差，以及（e）将多个检测器堆积到MRI孔中的紧凑型构想。提出的成像系统将高场（9.4 T）MRI扫描仪与超高SPECT系统相结合。它允许对在MR和SPECT图像中分析的功能进行出色的共同注册。所提出的系统将用于胰腺β细胞中的成像代谢和信号传导靶标。研究结果将增强我们对2细胞丢失和复制模型中每种成像方式的优势和局限性的理解。 公共卫生相关性：2型糖尿病（T2DM）是我们时代最重要的医疗问题之一，在美国影响了超过2000万人的发病率，总计超过2000亿美元/年，总医疗费用和工资损失。治疗自身免疫性1型糖尿病的新方法也将受益于对B细胞质量/功能的评估，以监测免疫攻击和可能的持续复制以及由STEM或其他祖细胞产生的移植胰岛或B细胞的命运[9-11]。有用的，经过验证的技术仍然是长期追求的目标。在这个项目中，我们将开发一个组合的SPECT/MRI系统，该系统专用于小型实验室动物中的放射性标记细胞。该系统将提供一种独特的仪器，用于非侵入性评估小鼠的B细胞质量和功能。我们还期望超高分辨率SPECT系统和高场MRI系统的结合将对许多其他区域产生重大影响，例如放射性标记的干细胞和T细胞的体内跟踪以及小动物中的肿瘤。