Advancing Physiological Signal Analysis for Mind-Body Research

推进身心研究的生理信号分析

• 批准号: 8114160
• 负责人: Barry S Oken
• 金额: $ 19.28万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8114160
• 关键词: Adherence; Algorithms; Basic Science; Behavioral; Brain; Caregivers; Clinical; Clinical Research; Clinical Trials; Complementary Medicine; Complex; Computer software; Data; Dementia; Development; Devices; Doctor of Philosophy; Educational Curriculum; Elderly; Electroencephalography; Environment; Faculty; Funding; Goals; Grant; Health; Health Promotion and Care; Home environment; Hour; Information Theory; Intervention; Intervention Studies; K-Series Research Career Programs; Laboratories; Lead; Measurement; Measures; Medical; Meditation; Mentors; Mentorship; Methodology; Mind-Body Intervention; Mind-Body Method; Neurosciences; Nonlinear Dynamics; Personal Digital Assistant; Phase; Physiological; Postdoctoral Fellow; Procedures; Publications; Qualifying; Relative (related person); Research; Research Personnel; Role; Sampling; Science; Signal Transduction; Stress; System; Techniques; Time; Training; United States National Institutes of Health; Universities; Veterans; Wages; Work; base; body-mind; career development; data acquisition; experience; graduate student; heart rate variability; improved; innovation; interest; lectures; mindfulness; mindfulness meditation; pre-doctoral; programs; public health relevance; user-friendly

DESCRIPTION (provided by applicant): This mid-career development award will provide protected time for Dr. Oken to mentor and to advance his capability in physiological signal acquisition and analysis. While already a successful mentor, as evidenced by his mentees becoming successful NIH-funded academicians, his time has been and will be further limited by the lack of any salary support for the T32 he directs. This successful T32 currently has 5 post-doctoral and one pre-doctoral candidate. The pre-doctoral candidate is the first on the T32 and she has declared Dr Oken to be her primary mentor for her Behavioral Neuroscience PhD thesis. In addition to increasing current mentorship roles, the K24 will allow Dr. Oken to develop a formal curricula for the T32 he directs, give CAM-related lectures to non-CAM clinical research and basic science trainees, and to allocate time to the mentorship and career development program that the OHSU associate dean is developing. Besides sufficient funding to better mentor others, Dr. Oken will also spend a significant portion of this career development award advancing his lab's capability for signal analysis and acquisition including the enhanced use of a 24-hour recording device that is interfaced with a personal digital assistant. This development will utilize the technical support of Mikel Aickin, PhD, Deniz Erdgomus, PhD, and Roger Ellingson, MSEE. These systems will be available to those on the T32 and other junior faculty interested in these techniques. Some of the career development funds will allow Dr. Oken to take graduate level Systems Science courses at Portland State University. The analysis techniques will aid development of: a physiologic measure of adherence to and quality of meditation interventions; a measure of interelectrode EEG correlation based on information theory that is likely more valid than parametric synchrony measures already used by others in the field; and a stress- sensitive measure of 24-hour heart rate variability. The personal digital assistant interfaced to the 24-hour recording device allows for frequent, experience-based sampling of self-rated measures relevant to mind-body such as perceived stress and mindfulness outside the laboratory in the subject's usual environment. These measurements will be related to the physiological measurements using systems science approaches. PUBLIC HEALTH RELEVANCE: The general goal of this application is to promote Dr. Oken's ability to better mentor clinical complementary medicine researchers and to advance the field of mind-body research. This will be done by allowing Dr. Oken to decrease some of his administrative and clinical responsibilities and by developing new physiologic measures that can be used in mind-body research, including measures of stress, adherence to interventions, and positive effects on the brain. From a practical perspective this application will lead to more qualified young CAM clinical researchers and to improved clinical trials of mind-body medicine. Improved understanding of the benefits of mind-body medicine and possibly even improving mind-body techniques themselves has broad health implications to almost all medical care and health promotion.

描述（由申请人提供）：该职业中期发展奖将为 Oken 博士提供受保护的时间来指导和提高他在生理信号采集和分析方面的能力。虽然他已经是一位成功的导师，正如他的学员成为 NIH 资助的成功院士所证明的那样，但由于他所领导的 T32 缺乏任何薪资支持，他的时间已经并将进一步受到限制。本次成功的T32目前拥有5名博士后和1名博士生。这位博士前候选人是 T32 上的第一位博士生，她已宣布奥肯博士为她行为神经科学博士论文的主要导师。除了增加当前的指导角色外，K24 还将允许 Oken 博士为他指导的 T32 开发正式课程，向非 CAM 临床研究和基础科学学员提供 CAM 相关讲座，并分配时间给指导和指导。 OHSU 副院长正在制定职业发展计划。除了足够的资金来更好地指导他人之外，奥肯博士还将花费职业发展奖的很大一部分来提高他的实验室的信号分析和采集能力，包括加强使用与个人数字助理连接的 24 小时记录设备。这一开发将利用 Mikel Aickin 博士、Deniz Erdgomus 博士和 Roger Ellingson 电机工程学硕士的技术支持。这些系统将提供给 T32 人员和其他对这些技术感兴趣的初级教师。部分职业发展资金将允许奥肯博士在波特兰州立大学修读研究生水平的系统科学课程。分析技术将有助于开发： 冥想干预的依从性和质量的生理测量；基于信息论的电极间脑电图相关性测量，可能比该领域其他人已经使用的参数同步测量更有效；以及 24 小时心率变异性的压力敏感测量。与 24 小时记录设备连接的个人数字助理允许对与身心相关的自评测量进行频繁的、基于经验的采样，例如实验室外受试者通常环境中的感知压力和正念。这些测量将与使用系统科学方法的生理测量相关。 公共卫生相关性：此应用程序的总体目标是提高 Oken 博士更好地指导临床补充医学研究人员并推进身心研究领域的能力。这将通过允许奥肯博士减少他的一些行政和临床职责，并开发可用于身心研究的新生理测量方法来实现，包括压力测量、坚持干预措施以及对大脑的积极影响。从实践的角度来看，这一应用将带来更多合格的年轻 CAM 临床研究人员，并改善身心医学的临床试验。提高对身心医学益处的了解，甚至可能改进身心技术本身，对几乎所有医疗保健和健康促进都有广泛的健康影响。