Advancing Physiological Signal Analysis for Mind-Body Research

推进身心研究的生理信号分析

• 批准号: 8298946
• 负责人: Barry S Oken
• 金额: $ 19.65万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8298946
• 关键词: Adherence; Algorithms; Basic Science; Behavioral; Brain; Caregivers; Clinical; Clinical Research; Clinical Trials; Complementary Medicine; Complex; Computer software; Data; Dementia; Development; Devices; Doctor of Philosophy; Educational Curriculum; Elderly; Electroencephalography; Environment; Faculty; Funding; Goals; Grant; Health; Health Promotion and Care; Home environment; Hour; Information Theory; Intervention; Intervention Studies; K-Series Research Career Programs; Laboratories; Lead; Measurement; Measures; Medical; Meditation; Mentors; Mentorship; Methodology; Mind-Body Intervention; Mind-Body Method; Neurosciences; Nonlinear Dynamics; Personal Digital Assistant; Phase; Physiological; Postdoctoral Fellow; Procedures; Publications; Qualifying; Relative (related person); Research; Research Personnel; Role; Sampling; Science; Signal Transduction; Stress; System; Techniques; Time; Training; United States National Institutes of Health; Universities; Veterans; Wages; Work; base; body-mind; career development; data acquisition; experience; graduate student; heart rate variability; improved; innovation; interest; lectures; mindfulness; mindfulness meditation; pre-doctoral; programs; public health relevance; user-friendly

DESCRIPTION (provided by applicant): This mid-career development award will provide protected time for Dr. Oken to mentor and to advance his capability in physiological signal acquisition and analysis. While already a successful mentor, as evidenced by his mentees becoming successful NIH-funded academicians, his time has been and will be further limited by the lack of any salary support for the T32 he directs. This successful T32 currently has 5 post-doctoral and one pre-doctoral candidate. The pre-doctoral candidate is the first on the T32 and she has declared Dr Oken to be her primary mentor for her Behavioral Neuroscience PhD thesis. In addition to increasing current mentorship roles, the K24 will allow Dr. Oken to develop a formal curricula for the T32 he directs, give CAM-related lectures to non-CAM clinical research and basic science trainees, and to allocate time to the mentorship and career development program that the OHSU associate dean is developing. Besides sufficient funding to better mentor others, Dr. Oken will also spend a significant portion of this career development award advancing his lab's capability for signal analysis and acquisition including the enhanced use of a 24-hour recording device that is interfaced with a personal digital assistant. This development will utilize the technical support of Mikel Aickin, PhD, Deniz Erdgomus, PhD, and Roger Ellingson, MSEE. These systems will be available to those on the T32 and other junior faculty interested in these techniques. Some of the career development funds will allow Dr. Oken to take graduate level Systems Science courses at Portland State University. The analysis techniques will aid development of: a physiologic measure of adherence to and quality of meditation interventions; a measure of interelectrode EEG correlation based on information theory that is likely more valid than parametric synchrony measures already used by others in the field; and a stress- sensitive measure of 24-hour heart rate variability. The personal digital assistant interfaced to the 24-hour recording device allows for frequent, experience-based sampling of self-rated measures relevant to mind-body such as perceived stress and mindfulness outside the laboratory in the subject's usual environment. These measurements will be related to the physiological measurements using systems science approaches. PUBLIC HEALTH RELEVANCE: The general goal of this application is to promote Dr. Oken's ability to better mentor clinical complementary medicine researchers and to advance the field of mind-body research. This will be done by allowing Dr. Oken to decrease some of his administrative and clinical responsibilities and by developing new physiologic measures that can be used in mind-body research, including measures of stress, adherence to interventions, and positive effects on the brain. From a practical perspective this application will lead to more qualified young CAM clinical researchers and to improved clinical trials of mind-body medicine. Improved understanding of the benefits of mind-body medicine and possibly even improving mind-body techniques themselves has broad health implications to almost all medical care and health promotion.

描述（由申请人提供）：这项职业中期发展奖将为Oken博士提供指导的保护时间，并提高其在生理信号获取和分析方面的能力。尽管已经成为成功的导师，但他的受训者证明了成功的NIH资助的院士，但由于缺乏对他指示的T32的薪水支持，他的时代已经并且将受到进一步的限制。该成功的T32目前有5个博士后和1名候选人。博士前候选人是T32上的第一个候选人，她宣布Oken博士是她的行为神经科学博士学位论文的主要导师。除了增加当前的指导角色外，K24还将允许Oken博士为他指导的T32开发正式课程，为非CAM临床研究和基础科学学员提供与CAM相关的讲座，并将时间分配给OHSU Asseciate Dean正在发展的指导和职业发展计划。除了足够的资金以更好地指导他人之外，Oken博士还将花费大部分职业发展奖，推动其实验室的信号分析和收购能力，包括增强使用与个人数字助手相连的24小时录音设备的使用。这一发展将利用Mikel Aickin博士，Deniz Erdgomus博士和MSEE的Roger Ellingson的技术支持。这些系统将适用于T32和其他对这些技术感兴趣的初级教师的人。一些职业发展资金将使Oken博士可以参加波特兰州立大学的研究生水平系统科学课程。分析技术将有助于开发：对冥想干预措施的依从性和质量的生理度量；基于信息理论的电极间脑电图相关性的度量可能比现场其他人已经使用的参数同步度量更有效。以及24小时心率变异性的应激敏感度量。连接到24小时录制设备的个人数字助理可以频繁地，基于经验的基于经验的措施采样与心身有关的自我评估措施，例如在受试者通常的环境中实验室之外的感知压力和正念。这些测量将与使用系统科学方法的生理测量有关。 公共卫生相关性：该应用程序的一般目标是促进Oken博士更好地指导临床补充医学研究人员并推进思维体研究领域的能力。这将通过允许Oken博士减少他的某些行政和临床责任，并制定可用于思维身体研究的新生理措施，包括压力的度量，遵守干预措施以及对大脑的积极影响。从实际的角度来看，该应用将导致更合格的年轻CAM临床研究人员，并改善心身医学的临床试验。对思维医学的好处，甚至可能改善思维技术本身的理解，对几乎所有的医疗和健康促进都具有广泛的健康影响。