Multidisciplinary Training in Brain Disorders and Development

脑部疾病和发育的多学科培训

• 批准号: 8073980
• 负责人: John William Swann
• 金额: $ 12.57万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8073980
• 关键词: Brain Diseases; Development; Training; multidisciplinary

DESCRIPTION (provided by applicant): The goal of this postdoctoral training program is to train young scientists, particularly physician scientists, and promote careers focused on understating and developing treatments for developmental brain disorders. Multidisciplinary training is planned in scientific disciplines relevant to the study of neurodevelopmental disorders. Thus, 21 training faculty have been selected from 5 departments. They include: 3 MDs, 2 MD/PhDs and 16 PhDs. There are: 11 Professors, 4 Associate Professors and 6 Assistant Professors. There are currently 70 postdoctoral students training in laboratories of the faculty and include 10 MD/PhDs, 10 MDs and 50 PhDs. Dr. John Swann will continue to serve as the Program Director and will be responsible for the day-to-day operation of the program. Drs. Huda Zoghbi and Jeff Noebels will continue to serve as co-directors. Major areas of training include the genetic and molecular basis of neurodevelopmental disorders including but not limited to: Rett syndrome, Angelman syndrome, Fragile X syndrome and Autism. Another concentrated area of training is in epilepsy where the molecular bases of the inherited as well as acquired epilepsies are studied. All laboratories employ cutting edge biotechnology to create and study relevant animals models of disease in order to not only understand the biological basis for these disorders but to screen potential new therapies that could lead to clinical trials and eventually enter clinical practice. During the current funding cycle, 10 postdoctoral students have thus far entered our training program and 6 are already faculty members at major universities. These include 3 MD/PhD child neurologists that have been awarded K08 grants and are now pursuing research careers. Three training tracks are offered. One is for MD/PhDs and MDs with substantial research experience. Another is for less experienced MDs where training is more formal and includes laboratory rotations and graduate courses. PhDs receive substantial training in clinical aspects of neurodevelopmental disorders through Dinner Discussions, clinical conferences and subspecialty clinics. Baylor College of Medicine and Texas Children's Hospital have committed substantial resources to the study of the neurobiology of disease and are currently planning the creation of the "Texas Children's Neurological Research Institute" which promises to become a major center for postdoctoral training for generations to come. By training outstanding research scientists, we feel new understandings and treatments for the devastating developmental disorders in infants and young children will emerge.

描述（由申请人提供）：该博士后培训计划的目的是培训年轻科学家，特别是医师科学家，并促进专注于低估和开发发育性脑疾病治疗的职业。多学科培训计划在与神经发育障碍研究有关的科学学科中。因此，从5个部门选出了21位培训教师。它们包括：3个MD，2个MD/PHD和16位。有：11位教授，4位副教授和6名助理教授。目前，有70名教师实验室的博士后学生培训，包括10名MD/Phds，10个MDS和50位博士学位。约翰·斯旺（John Swann）博士将继续担任该计划主任，并将负责该计划的日常运作。博士。 Huda Zoghbi和Jeff Noebels将继续担任联合导演。训练的主要领域包括神经发育障碍的遗传和分子基础，包括但不限于：RETT综合征，Angelman综合征，脆弱的X综合征和自闭症。训练的另一个集中区域是癫痫病，研究了遗传的分子底部以及所获得的癫痫。所有实验室都采用最先进的生物技术来创建和研究相关的疾病模型，以便不仅了解这些疾病的生物学基础，而且还要筛选可能导致临床试验并最终进入临床实践的潜在新疗法。在当前的资金周期中，到目前为止，有10名博士后学生进入了我们的培训计划，其中6名已经是主要大学的教职员工。其中包括3名MD/PhD儿童神经科医生，这些医生已获得K08赠款并正在从事研究职业。提供了三个训练轨道。一种用于具有丰富研究经验的MD/PHD和MD。另一个是对于经验不足的医学博士，培训更正式，包括实验室轮换和研究生课程。通过晚餐讨论，临床会议和专科诊所，博士在神经发育障碍的临床方面接受了大量培训。贝勒医学院和德克萨斯州儿童医院已为疾病神经生物学研究提供了大量资源，目前正计划创建“德克萨斯州儿童神经研究所”，该研究所有望成为以后几代人的主要培训中心。通过培训杰出的研究科学家，我们会发现婴儿和幼儿的毁灭性发育障碍的新理解和治疗方法。