Mutidisciplinary Training; Brain Disorders & Development

多学科培训；

• 批准号: 6454102
• 负责人: John William Swann
• 金额: $ 9.09万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6454102
• 关键词: Mutidisciplinary; Training; Brain; Disorders; Development

DESCRIPTION (provided by applicant) The goal of this new postdoctoral program is to train young scientists, particularly physician scientists, and promote careers focused on understanding the basic mechanisms underlying disorders of the developing nervous system. Multidisciplinary training is planned in scientific disciplines relevant to the study of neurodevelopmental disorders. Thus, 19 training faculty were selected from 5 departments. The faculty includes 4 MDs, 2 MD/Ph.Ds and 13 Ph.Ds. Their ranks are: 11 Professors, 3 Associate Professors and 5 Assistant Professors. Dr. Swann will serve as Program Director and be responsible for the day-to-day operation of the program. Dr. Zoghbi and Dr. Noebels will serve as Co-Directors. Major training areas include the genetic and molecular basis of inherited neurodevelopmental disorders including: Rett Syndrome, Angelman's Syndrome, Fragile X Syndrome, Downs Syndrome, Miller-Dicker Lissencephaly and Generalized Spike-Wave Epilepsy. Another, shared focus of study will be epilepsy where neuroscience laboratories use advanced imaging and electrophysiological techniques to study the cellular and molecular abnormalities relevant to chronic models of both inherited and acquired seizure disorders. All the laboratories of the faculty provide expertise in cutting-edge biotechnology for the creation and study of animal models. Three separate training tracks are planned. One is for MD/PhDs and MDs with substantial basic science research experience. Another is for less experienced MDs and the third for PhDs. These latter MD students will be advised by individualized research advisory committees on their choice of laboratory rotations and graduate level courses. PhDs will receive substantial training in the clinical aspects of neurodevelopmental disorders through clinical conferences, subspeciality clinics and hospital rounds. Baylor College of Medicine has committed substantial resources to the study of the basic mechanisms of diseases including those of the developing brain. Laboratory space and core laboratories are outstanding. Pediatric Neurology clinics, laboratories and centers, including a NIH funded Mental Retardation Research Center, will be important resources for postdoctoral trainees. There are currently 84 postdoctoral students in the laboratories of the training faculty, including 14 MD/PhDs, 8 MDs and 62 PhDs. By training a new generation of outstanding research scientists, we hope new approaches for the treatment and cure of devastating developmental disorders in infants and young children will emerge.

描述（由申请人提供） 这个新的博士后项目的目标是培养年轻科学家， 特别是医师科学家，并促进专注于理解的职业 神经系统发育障碍的基本机制。 计划在与该领域相关的科学学科中进行多学科培训 神经发育障碍的研究。至此，19名培训教师被选拔出来 来自5个部门。教师包括 4 名医学博士、2 名医学博士/博士和 13 名博士。他们的 职称：教授11人，副教授3人，助理教授5人。 Swann 博士将担任项目总监并负责日常工作 程序的运行。 Zoghbi 博士和 Noebels 博士将担任 联合董事。主要培训领域包括遗传和分子基础 遗传性神经发育障碍包括：雷特综合症、天使综合症 综合症、脆性 X 综合症、唐氏综合症、米勒-迪克无脑畸形和 全身性棘波癫痫。另一个共同的研究重点是 神经科学实验室使用先进的成像技术和 研究细胞和分子的电生理技术 与遗传性和获得性癫痫发作慢性模型相关的异常 失调。学院的所有实验室都提供以下方面的专业知识： 用于动物模型创建和研究的尖端生物技术。三 计划单独的训练轨道。一种是针对医学博士/博士和医学博士 丰富的基础科学研究经验。另一种是针对经验不足的 医学博士，第三个是博士学位。这些后者的医学博士生将得到以下建议 个性化研究咨询委员会选择实验室 轮换和研究生水平课程。博士将接受大量培训 通过临床研究神经发育障碍的临床方面 会议、亚专科诊所和医院查房。贝勒学院 医学界投入了大量资源来研究基础知识 疾病的机制，包括发育中的大脑的疾病机制。实验室 空间和核心实验室非常出色。小儿神经内科诊所， 实验室和中心，包括 NIH 资助的精神发育迟滞研究 中心，将成为博士后培训生的重要资源。有 目前培养教师实验室有84名博士后学生， 其中医学博士/博士14人，医学博士8人，博士62人。通过培训新一代 杰出的研究科学家，我们希望有新的治疗方法和 治愈婴儿和幼儿的破坏性发育障碍将 出现。