Pediatric Research: Bench to Bedside to Curbside

儿科研究：从长凳到床边再到路边

• 批准号: 8065861
• 负责人: NINA F SCHOR
• 金额: $ 24.3万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8065861
• 关键词: Pediatric Research; bench to bedside

DESCRIPTION (provided by applicant): Although some recognition of the unique aspects of the biology of the developing child clearly began in the 1800's, pediatrics did not evolve as an independent intellectual and clinical discipline until the 1900's. Since then, this relative newcomer to both the clinic and the research laboratory has begun to bear considerable fruit. Identification of the gene defects responsible for metabolic and degenerative diseases and new models for care delivery and preventive medicine in inner cities are examples of contributions of pediatric research to the body of knowledge that spans the gap between the clinic and the basic science laboratory. However, increasing emphasis on revenue generation, care for those who constitute the taxpaying and voting workforce, and repayment of medical school debt have made it increasingly difficult to attract, foster, and maintain a cadre of individuals whose interests are in the development of a translational body of pediatric knowledge and the dialogue between the laboratory bench and the pediatric clinic and community. It is absolutely vital that we establish and nurture venues in which to train researchers at the interfaces between developmental biology and clinical practice and between the academic sector and the community. The present application proposes to take advantage of the high quality, interactive, and interdisciplinary faculty and environment of the University of Rochester to give clinically trained fellows the opportunity to engage in and understand basic, clinical, and/or translational research, develop in these fellows the thinking skills and knowledge base that will allow their application of basic biological principles towards enhancing and developing our understanding of the developmental origins and mechanisms of chronic disease throughout the lifespan. As the productive lifespan of individuals with childhood diseases increases and as our population ages, this understanding becomes crucial to development of preventive and severity-limiting strategies for human disease. PUBLIC HEALTH RELEVANCE: The proposed program will train clinically oriented fellows in research that bridges between laboratory bench and patient bedside and between patient bedside and community. This research will be aimed at understanding the childhood antecedents of chronic disease across the lifespan - a critical emphasis as our population ages and as children with previously life-threatening diseases can now live into productive adulthood.

描述（由申请人提供）：虽然从 1800 年代开始，人们就清楚地认识到发育中儿童的生物学独特之处，但儿科直到 1900 年代才发展成为一门独立的知识和临床学科。从那时起，这个相对较新的临床和研究实验室已经开始结出可观的成果。识别导致代谢和退行性疾病的基因缺陷以及内城区护理服务和预防医学的新模式是儿科研究对跨越诊所和基础科学实验室之间差距的知识体系做出贡献的例子。然而，对创收、对纳税和投票劳动力的关心以及医学院债务偿还的日益重视，使得吸引、培养和维持一支以转化医学发展为己任的骨干队伍变得越来越困难。儿科知识体系以及实验室工作台与儿科诊所和社区之间的对话。我们建立和培育在发育生物学和临床实践之间以及学术部门和社区之间的界面上培训研究人员的场所是绝对重要的。本申请建议利用罗切斯特大学高质量、互动性和跨学科的师资和环境，为受过临床培训的研究员提供参与和理解基础、临床和/或转化研究的机会，并在这些研究员中发展思维技能和知识基础将使他们能够应用基本的生物学原理来增强和发展我们对整个生命周期慢性疾病的发育起源和机制的理解。随着患有儿童疾病的人的生产寿命的延长以及人口的老龄化，这种理解对于制定人类疾病的预防和严重程度限制策略变得至关重要。 公共卫生相关性：拟议的计划将培训面向临床的研究人员，以在实验室工作台和患者床边以及患者床边和社区之间架起桥梁。这项研究旨在了解整个生命周期中慢性疾病的童年前因——随着人口老龄化以及以前患有危及生命疾病的儿童现在可以进入富有成效的成年期，这一点至关重要。