2023 Polyamines Gordon Research Conference and Gordon Research Seminar

2023年多胺戈登研究会议暨戈登研究研讨会

• 批准号: 10675969
• 负责人: ANDRE S BACHMANN
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-25 至 2023-07-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10675969
• 关键词: Academia; Adult; Aging; Alzheimer' s Disease; Amino Acids; Antineoplastic Agents; Applications Grants; Area; Asia; Basic Science; Biological Markers; Biological Models; Biology; Biotechnology; COVID-19 pandemic; Cancer Biology; Cancer Prevention Trial; Cell physiology; Cells; Childhood; Childhood Neurological Disorder; Clinic; Clinical; Clinical Trials; Collaborations; Colon Carcinoma; Communities; DL-alpha-Difluoromethylornithine; Degenerative Disorder; Development; Diabetes Mellitus; Discipline; Disease; Disorder of neurometabolic regulation; Drosophila genus; Drug Targeting; Environment; Epigenetic Process; Europe; FDA approved; Female; Fostering; Funding; Future; Genes; Genetic Transcription; Goals; Grant; Home; Human; Immunobiology; Immunologic Surveillance; Infection; Infusion procedures; Ion Channel; Life; Link; Location; Malignant Neoplasms; Malignant neoplasm of prostate; Mammals; Metabolic; Metabolic Diseases; Metabolism; Names; Natural Products; Neoplasm Metastasis; Neuroblastoma; Neurodevelopmental Disorder; Organism; Outcome; Parasites; Parasitic infection; Participant; Pathway interactions; Pediatric Oncology Group; Pharmaceutical Chemistry; Pharmacologic Substance; Phase I/II Clinical Trial; Physicians; Plants; Play; Polyamines; Postdoctoral Fellow; Prevention; Productivity; Prokaryotic Cells; Proteins; Randomized; Regulation; Request for Applications; Research; Research Personnel; Resort; Role; Running; Scientist; Series; Structural Biologist; Students; Syndrome; Training; Translational Research; Translations; Travel; United States National Institutes of Health; Vertebrates; Virulent; Work; Writing; bench to bedside; cancer chemoprevention; cancer clinical trial; cancer prevention; cancer therapy; career; career development; cost; data exchange; drug discovery; eIF-5A; experience; forging; gain of function mutation; graduate student; human disease; inhibitor; male; meetings; member; microbiome; multidisciplinary; next generation; pathogen; phase II trial; polycation; posters; programs; stemness; success; symposium; translational impact; tumor metabolism; tumorigenesis

Project Summary The Polyamines Gordon Research Conference (GRC) has run continuously since 1975 and provides a multidisciplinary forum that brings together leading polyamine researchers as well as young and established investigators new to the field. The 2023 Polyamines GRC will be held at Waterville Valley Resort in NH, from June 25-30, 2023. This GRC will have a broad focus on the role of polyamines in human diseases, with a major focus on cancer including breakthroughs in cancer metabolism and immune surveillance, advanced clinical trials for cancer prevention & treatment, metastasis and cancer stemness, protein translation, and medicinal chemistry-based cancer drug discovery. Other human diseases include several recently discovered inborn metabolic neurodevelopmental disorders linked to polyamine genes, diabetes, degenerative disorders, and pathogens. The meeting is unique in that it attracts a diverse array of top investigators assessing the control and roles of polyamines across a broad spectrum of model systems (prokaryotes, parasites, Drosophila, plants, vertebrates, and mammals). Polyamines are small, amino acid-derived polycations found in all forms of life and play essential roles in many cellular processes, including transcription, translation, replication, metabolism, epigenetic control, and ion channel functions. The 2023 Polyamines GRC will emphasize targeting polyamine pathways in cancer and other diseases. The Program has a strong mix of basic, translational, and clinical researchers. This GRC is attended by biologists, chemists, physician- scientists, and clinicians, and includes investigators from academia, biotech, and pharmaceutical sectors. The diversity of scientific disciplines is unique among GRCs, is highly stimulating, and will emphasize new findings relating to upstream and downstream pathways, and new diseases only recently linked to alterations in polyamine biology. We will bring the latest studies, new investigators to the field, and early career investigators to this forum. Of the 28 named speakers, 22 are new since the last GRC and have never spoken and/or are early career scientists. We will also choose 5 speakers from the Gordon Research Seminar (GRS) and the posters, which will add more new speakers. The specific aims seek to obtain funds to support 42 GRC & 15 GRS registrations, and travel costs for 15 GRC/GRS participants. The long-term objective is to enhance understanding of the interplay between polyamine metabolism and human diseases, and to enhance the training of young scientists from diverse backgrounds to become contributing members of the polyamine scientific community. Presentations by invited speakers will be 25-30 minutes, with a 10-minute discussion. The GRC will be held in conjunction with the 8th Polyamines, providing graduate students and fellows with a student-run venue that fosters exchange of data and ideas. The GRS makes the GRC a richer experience, by promoting young scientists during the main conference. Interactions between GRS & GRC conferees facilitate sharing of ideas and create new partnerships that will drive the field forward.

项目摘要 多胺戈登研究会议（GRC）自1975年以来一直在不断运行，并提供了 多学科论坛汇集了领先的多胺研究人员以及年轻人 新手的调查人员。 2023年多胺GRC将于新罕布什尔州的沃特维尔谷度假村举行 2023年6月25日至30日。此GRC将广泛关注多胺在人类疾病中的作用， 主要关注癌症，包括癌症代谢和免疫监测的突破，晚期 预防癌症和治疗，转移和癌症的临床试验，蛋白质翻译和 基于药物化学的癌症药物发现。其他人类疾病包括最近发现的几种 与多胺基因，糖尿病，退化性疾病相关的先天代谢神经发育障碍， 和病原体。会议的独特之处在于，它吸引了各种各样的顶级调查员评估 多胺在广泛的模型系统中的控制和作用（原核生物，寄生虫， 果蝇，植物，脊椎动物和哺乳动物）。多胺是在氨基酸衍生的小聚阳离子中发现的 各种形式的生活和在许多蜂窝过程中起着基本作用，包括转录，翻译， 复制，代谢，表观遗传控制和离子通道功能。 2023多胺GRC将 强调在癌症和其他疾病中靶向多胺途径。该程序具有很强的组合 基本，转化和临床研究人员。生物学家，化学家，医师 - 科学家和临床医生，包括来自学术界，生物技术和制药部门的研究人员。这 科学学科的多样性在GRC中是独一无二的，非常刺激，并将强调新的发现 与上游和下游途径有关，而新的疾病直到最近才与变化有关 多胺生物学。我们将将最新的研究，新的研究人员和早期职业调查员带到现场 到这个论坛。在28位命名的演讲者中，有22名是新的GRC，并且从未说话和/或 早期职业科学家。我们还将从戈登研究研讨会（GRS）和 海报，这将增加更多的新扬声器。具体的目的旨在获得支持42 GRC＆15的资金 GRS注册和15个GRC/GRS参与者的旅行费用。长期目标是增强 了解多胺代谢与人类疾病之间的相互作用，并增强 培训来自不同背景的年轻科学家成为多胺的贡献者 科学界。受邀演讲者的演讲将为25-30分钟，讨论10分钟。 GRC将与第八个多胺一起举行，为研究生和研究员提供 学生经营的场地促进了数据和想法的交换。 GRS使GRC成为更丰富的体验， 在主要会议期间促进年轻科学家。 GRS和GRC联合会之间的相互作用有助于 分享想法并建立新的合作伙伴关系，以推动该领域的前进。