A Diet Intervention Study To Mitigate Fatigue Symptoms And To Improve Muscle And Physical Function In Older Adults With Post-Acute COVID-19 Syndrome

一项饮食干预研究，旨在减轻患有急性后 COVID-19 综合症的老年人的疲劳症状并改善肌肉和身体功能

• 批准号: 10734981
• 负责人: Galya Bigman
• 金额: $ 12.42万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10734981
• 关键词: 2019-nCoV; Abate; Academia; Adherence; Adult; Aging; American; Anti-Inflammatory Agents; Attenuated; Baltimore; Biological Markers; Black Populations; COVID-19; Clinical Trials; Complex; Control Groups; Coupled; Deterioration; Diet; Dietary Fiber; Dietary Intervention; Dietitian; Disease; Dual-Energy X-Ray Absorptiometry; Education; Elderly; Equilibrium; Equipment and supply inventories; Exhibits; Fatigue; Feasibility Studies; Food; Fruit; Future; Geriatrics; Hand Strength; Health; Healthy Eating; Hispanic Populations; Hour; Individual; Infection; Inflammation; Inflammatory; Intake; Interleukin-6; Intervention; Intervention Studies; Leadership; Life; Long COVID; Maryland; Measures; Mentored Research Scientist Development Award; Mentors; Mentorship; Muscle; Muscle Weakness; Muscle function; Not Hispanic or Latino; Nutrient; Nutritional; Nutritional Study; Omega-3 Fatty Acids; Participant; Pathology; Physical Function; Physical Performance; Plants; Proteins; Public Health; Randomized; Randomized, Controlled Trials; Recommendation; Recovery; Research Personnel; Sampling; Seafood; Structure; Symptoms; Systemic disease; Testing; Thinness; Training; Translating; Underrepresented Minority; Universities; Vegetables; Vitamin D; Walking; Whey Protein; Woman; aged; attentional control; bean; career; common symptom; comparison control; coronavirus disease; dietary; dietary guidelines; eligible participant; ethnic minority; experience; group intervention; improved; indexing; men; multidisciplinary; muscle form; nutrition; pandemic disease; preservation; prevent; racial minority; skills; statistics

Nearly one in five American adults who survived the coronavirus disease (COVID-19) are still suffering from post-acute COVID-19 syndrome (PACS),42 a complex systemic disease manifests in fatigue and muscle weakness that substantially limits one or more major life activities.35-41,92 For older adults, having PACS coupled with an inadequate diet may compound their health deterioration and hasten their physical function decline. 43- 44 Nutritional studies demonstrate that a whole diet comprises foods high in anti-inflammatory activities, e.g., whole grains, fruits, vegetables, and omega-3 fatty acid-rich foods substantially reduce disease-related fatigue, likely by reducing inflammation.49-50 U.S. adults who followed the Dietary Guidelines for Americans (DGA) were more likely to preserve muscle grip strength than those who did not.17 Since fatigue and physical function are interrelated, a ‘Whole-Diet Approach’56,61,62 aligned with the DGA60 with a focus on nutrients high anti- inflammatory activities may be an effective strategy to ameliorate recovery from PACS in older adults. This project proposes to examine, in a 16-week randomized-controlled dietary intervention, the effect of the ‘Whole- Diet Approach’ on mitigating symptoms of PACS related to nutrition, e.g., fatigue and muscle weakness and will explore the underlying mechanisms via biomarkers. The sample will comprise men and women aged 50 years or older with PACS, including underrepresented minorities (50% Non-Hispanic-Blacks). At baseline, N=56 eligible participants will be randomized to either: 1) a dietary intervention following the new DGA with a focus on nutrients high in anti-inflammatory activities via foods and or supplements (e.g., vitamin D, omega-3, and whey); or 2) attention control. Aim 1. In a 16-week, randomized-controlled trial, we will examine the effect of the Whole-Diet Approach (WDA) on the Healthy Eating Index (HEI) and fatigue compared to attention control in adults with PACS. Aim 2. To assess the impact of the dietary intervention following the WDA on muscle mass, strength, and physical function compared to attention control in adults with PACS. Aim 3. To explore the mechanism of decreased fatigue and improved muscle and physical function by examining changes in nutritional and inflammatory biomarkers from baseline to 16 weeks. The proposed dietary intervention to attenuate PACS in older adults is a feasible study relevant to public health. The University of Maryland Baltimore provides a unique opportunity to be trained by a multidisciplinary team of mentors who are experts in clinical trials, muscle, physical function, nutrition, geriatrics, statistics, and COVID-19 to conduct this study successfully. The findings can be translated into a new strategy to counteract fatigue and physical function decline following PACS. The K01 Award will provide me with the training I need to become an independent investigator in dietary trials to advance the field of nutrition and aging while gaining the skills and experience in leadership and mentorship to launch my career in academia.

在冠状病毒病（Covid-19）中幸存下来的近五分之一的美国成年人仍患有 急性后共导致-19综合征（PACS），42一种复杂的全身性疾病在疲劳和肌肉中表现出来 实质上限制了一项或多项重大生活活动的弱点。老年人35-41,92，使PACS耦合 饮食不足可能会使他们的健康定义加剧，并加快其身体功能下降。 43-- 44营养研究表明，整个饮食包括抗炎活动中的食物，例如 全谷物，水果，蔬菜和欧米茄3脂肪酸富含脂肪的食物大大减轻了与疾病相关的疲劳， 可能通过减少炎症。49-50位遵循美国人饮食指南（DGA）的美国成年人是 比没有那些的更有可能保持肌肉抓地力。17因为疲劳和身体功能是 相互关联的“全境方法” 56,61,62与DGA60保持一致，重点是营养高。 炎症活动可能是改善老年人中PAC恢复的有效策略。这 项目提案，以16周的随机控制饮食干预措施检查整个饮食的影响 饮食方法'缓解与营养有关的PAC的症状，例如疲劳和肌肉无力和 将通过生物标志物探索潜在的机制。样本将完成50岁的男人和女性 PAC的年龄或以上的年限，包括代表性不足的少数族裔（50％非西班牙裔黑人）。基线， n = 56名合格的参与者将被随机分配给：1）新DGA之后的饮食干预措施 通过食物和或补充剂（例如，维生素D，Omega-3， 为什么）;或2）注意力控制。 目的1。在一项为期16周的随机控制试验中，我们将检查整个方法的效果 （WDA）与患有PAC的成年人的注意力控制相比，健康饮食指数（HEI）和疲劳。 目标2。评估WDA后饮食干预对肌肉质量，力量和力量的影响 与PAC的成年人的注意力控制相比。 目标3。探索减轻疲劳的机制，通过 检查从基线到16周的营养和炎症生物标志物的变化。 拟议的饮食干预措施减轻老年人的PAC是一项与公众有关的可行研究 健康。马里兰州巴尔的摩大学提供了一个独特的机会，可以通过多学科培训 是临床试验，肌肉，身体机能，营养，老年医学，统计和统计专家的导师团队 COVID-19成功地进行了这项研究。这些发现可以转化为一种新策略来抵消 PACS之后的疲劳和身体机能下降。 K01奖将为我提供我需要的培训 成为饮食试验中的独立研究者，以促进营养和衰老领域 领导和心态方面的技能和经验，以启动我在学术界的职业。