Translational Molecular Pediatric Research

转化分子儿科研究

• 批准号: 8088945
• 负责人: NINA F SCHOR
• 金额: $ 35.1万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-25 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8088945
• 关键词: Biology; Child; Childhood; Clinical; Development; Developmental Biology; Discipline; Disease; Environment; Faculty; Fostering; Funding; Generations; Individual; Knowledge; Molecular; Molecular Biology; Pediatric Research; Pediatrics; Research Personnel; Thinking; Training; Translational Research; Universities; interest; knowledge base; medical schools; skills

DESCRIPTION (provided by applicant): Although some recognition of the unique aspects of the biology of the developing child clearly began in the 1800's, pediatrics did not evolve as an independent intellectual and clinical discipline until the 1900's. Only relatively recently have emerging molecular principles been systematically applied to the understanding and treatment of diseases of childhood. However, increasing emphasis on revenue generation, decreasing availability of institutional start-up funds for new investigators, and the individual's imperative for repayment of medical school debt have made it increasingly difficult to attract, foster, and maintain a cadre of individuals whose interests are in the development of a translational body of molecular and developmental pediatric knowledge. It is absolutely vital that we establish and nurture venues in which to train researchers at the interfaces between molecular and developmental biology and pediatrics. The present application proposes to take advantage of the high quality, interactive, and interdisciplinary faculty and environment of the University of Rochester to give clinically trained junior faculty the opportunity to engage in and understand basic, and translational research, develop in these fellows the thinking skills and knowledge base that will allow their application of basic molecular principles towards enhancing and developing our understanding of the developmental origins and mechanisms of childhood disease. PUBLIC HEALTH RELEVANCE: The proposed program will train clinically oriented junior faculty to prepare them for and launch them in careers in molecular pediatrics research. This research will be aimed at understanding and treating diseases of childhood.

描述（由申请人提供）：虽然从 1800 年代开始，人们就清楚地认识到发育中儿童的生物学独特之处，但儿科直到 1900 年代才发展成为一门独立的知识和临床学科。直到最近，新兴的分子原理才被系统地应用于儿童疾病的理解和治疗。然而，对创收的日益重视、新研究者可用机构启动资金的减少以及个人偿还医学院债务的迫切性，使得吸引、培养和维持一支与自己利益相关的个人骨干队伍变得越来越困难。分子和发育儿科知识转化体的发展。我们建立和培育在分子和发育生物学与儿科之间的交叉领域培训研究人员的场所是绝对重要的。本申请旨在利用罗切斯特大学高质量、互动和跨学科的师资队伍和环境，为受过临床培训的初级教师提供参与和理解基础研究和转化研究的机会，培养这些研究员的思维能力和知识库，使他们能够应用基本分子原理来增强和发展我们对儿童疾病的发育起源和机制的理解。 公共健康相关性：拟议的计划将培训面向临床的初级教师，为他们做好准备并启动他们从事分子儿科研究的职业。这项研究旨在了解和治疗儿童疾病。