CONTE CENTER

孔特中心

• 批准号: 8172366
• 负责人: Stuart Zola
• 金额: $ 4.39万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172366
• 关键词: Animals; Anxiety; Behavior; Behavioral; Brain; Brain Chemistry; Brain imaging; Cerebrum; Cocaine; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Development; Emotional; Emotions; Extinction (Psychology); Fright; Funding; Grant; Implant; Institution; Investigation; Life Stress; Memory; Monkeys; Positron-Emission Tomography; Research; Research Personnel; Resistance; Resources; Self Administration; Source; Stress; Telemetry; Testing; Training; United States National Institutes of Health; cohort; glucose metabolism; neurochemistry; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project has three studies that utilize the cohorts of stressed and control nonhuman primates generated during the previous funding period of the Conte grant. Study 1 investigators examined the effects of early stress on subsequent cognitive abilities, with an emphasis on declarative and non-declarative memory functions. Study 2 investigators looked at the effects of early stress on the development of emotional behavior, with an emphasis on fear and anxiety, and changes in cerebral glucose metabolism. Study 3 investigator asked whether early stress results in acquiring cocaine self-administration more rapidly than control monkeys, and whether there is more resistance to extinction compared to control monkeys. The studies used structural and/or functional brain imaging to clarify the relationship between behavioral changes and changes in brain, and will look at neurochemical assessments to clarify the relation between behavioral changes and brain chemistry due to early life stress. Study 1 and Study 2 use the same groups of monkeys. This is both an efficient use of a very valuable resource that allows us to compare findings in two different domains of behavior, i.e., memory and emotion, in the same animals. By necessity, an entirely separate group of monkeys is being used for Study 3. Monkeys continued to be tested. Several have been fitted with telemetry implants and undergone PET studies. Study 3 monkeys are nearing completion of training. This was the final year of funding under the Conte Center grant. The animals are being reassigned to projects that will allow us to continue investigations into the effects of early life stress.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目有三项研究，利用了在孔戴赠款的前一期资金期间产生的压力和控制非人类灵长类动物的同类。 研究1研究者研究了早期应力对随后的认知能力的影响，并着重于声明性和非定性记忆功能。 研究2研究者研究了早期压力对情绪行为发展的影响，重点是恐惧和焦虑，以及脑葡萄糖代谢的变化。 研究3研究者询问早期应力是否会比对照猴子更快地获得可卡因自我给药，以及与对照猴子相比，对灭绝的抵抗力更大。 研究使用结构和/或功能性脑成像来阐明行为变化与大脑变化之间的关系，并将研究神经化学评估，以阐明由于早期生命应力而导致的行为变化与大脑化学之间的关系。 研究1和研究2使用相同的一组猴子。这既是对非常有价值的资源的有效利用，它使我们能够在两个不同的行为领域（即记忆和情感）中比较同一动物中的​​记忆和情感。必要时，正在使用一组完全独立的猴子进行研究3。 猴子继续进行测试。 一些人已经配备了遥测植入物和宠物研究。研究3猴即将完成培训。 这是孔戴中心拨款下资金的最后一年。这些动物被重新分配到将使我们能够继续调查早期生活压力的影响的项目。