SENSITIVE MEMORY TESTS FOR DIFFERENTIATING MCI SUBGROUPS

用于区分 MCI 子组的灵敏内存测试

• 批准号: 8357430
• 负责人: Stuart Zola
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357430
• 关键词: Alzheimer' s Disease; Award; Behavioral; Clinical; Eye; Funding; Goals; Grant; Impaired cognition; International; Memory; National Center for Research Resources; Nervous system structure; Paired Comparison; Patients; Performance; Populations at Risk; Primates; Principal Investigator; Recruitment Activity; Research; Research Infrastructure; Research Project Grants; Research Subjects; Resources; Risk; Source; Subgroup; Technology; Testing; Therapeutic Intervention; Time; United States National Institutes of Health; Visual; Work; abstracting; base; clinical Diagnosis; cost; symposium

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This research project is part of an Alzheimer's Disease Research Center (ADRC) grant awarded in 2005. The major goal of this work is to determine whether sensitive behavioral tasks, together with eye-tracking technology, will reveal a profile of performance in MCI patients that is useful in predicting the onset of Alzheimer's disease. Research subjects were recruited from the ADRC Clinical Core and were tested annually. We have successfully administered the preferential looking task together with eye-tracking in these subjects over several years and are now reviewing performance of these subjects in Year 1 together with their current clinical diagnosis. Our findings, which form the basis of an abstract submission to the International Conference on Alzheimer's Disease (ICAD) 2011, show that those subjects that performed poorly on the visual paired comparison task in the first year of testing are very likely to convert to AD within 4 years. This work is important since it allows us to identify the subset of MCI patients that are most at risk for oncoming cognitive decline. Once therapeutic interventions become available, this would be a key at-risk population to be targeted, at a time when the nervous system is less compromised and, accordingly, more likely to benefit.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该研究项目是阿尔茨海默病研究中心 (ADRC) 2005 年授予的资助的一部分。这项工作的主要目标是确定敏感行为任务与眼动追踪技术是否能够揭示 MCI 患者的表现概况：可用于预测阿尔茨海默病的发病。研究对象是从 ADRC 临床核心招募的，每年进行一次测试。几年来，我们已经成功地对这些受试者进行了优先注视任务和眼球追踪，现在正在审查这些受试者在第一年的表现以及他们当前的临床诊断。我们的研究结果构成了向 2011 年阿尔茨海默病国际会议 (ICAD) 提交的摘要的基础，该结果表明，那些在第一年测试中在视觉配对比较任务中表现不佳的受试者很可能在4年。这项工作很重要，因为它使我们能够识别出最有可能出现认知能力下降风险的 MCI 患者子集。一旦治疗干预措施可用，这将成为重点针对的高危人群，此时神经系统受到的损害较小，因此更有可能受益。