CONTE CENTER

孔特中心

• 批准号: 8357428
• 负责人: Stuart Zola
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357428
• 关键词: Animals; Anxiety; Award; Behavior; Behavioral; Brain; Brain Chemistry; Brain imaging; Cerebrum; Cocaine; Cognitive; Development; Emotional; Extinction (Psychology); Fright; Funding; Grant; Investigation; Life Stress; Memory; Monkeys; National Center for Research Resources; Primates; Principal Investigator; Research; Research Infrastructure; Resistance; Resources; Self Administration; Source; Stress; United States National Institutes of Health; cohort; cost; glucose metabolism; neurochemistry; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project (which was the final five-year renewal of the Conte grant) ended during the current period. It funded three studies that utilized the cohorts of stressed and control nonhuman primates generated during the initial funding period of the Conte grant. Study 1 examined the effects of early stress on subsequent cognitive abilities, with an emphasis on declarative and non-declarative memory functions. Study 2 looked at the effects of early stress on the development of emotional behavior, with an emphasis on fear and anxiety, and changes in cerebral glucose metabolism. Study 3 asked whether early stress results in acquiring cocaine self-administration more rapidly than control monkeys, and whether there is more resistance to extinction compared to control monkeys. The studies used structural and/or functional brain imaging to clarify the relationship between behavioral changes and changes in brain, and examined neurochemical assessments to clarify the relation between behavioral changes and brain chemistry due to early life stress. Studies 1 and 2 used the same groups of monkeys, and Study 3 used a separate group. Because the Conte Center grant funding has ended, the animals were reassigned to projects funded by a new Challenge Grant and Supplement awards that will allow us to continue investigations into the effects of early life stress.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 该项目（这是孔戴赠款的最后五年续约）在当前时期结束。它资助了三项研究，利用了在孔戴赠款的初始资金期间产生的压力和控制非人类灵长类动物的同类。研究1研究了早期应力对随后的认知能力的影响，并重点是声明性和非定性记忆功能。研究2研究了早期压力对情绪行为发展的影响，重点是恐惧和焦虑，以及脑葡萄糖代谢的变化。研究3询问早期压力是否会比对照猴子更快地获得可卡因自我给药，以及与对照猴子相比，对灭绝的抵抗力更大。该研究使用结构和/或功能性脑成像来阐明行为变化与大脑变化之间的关系，并检查了神经化学评估，以阐明由于早期生命压力而导致的行为变化与大脑化学之间的关系。研究1和2使用了相同的猴子组，研究3使用了单独的组。由于孔戴中心赠款的资金已经结束，因此将这些动物重新分配给了由新的挑战补助金和补充奖项资助的项目，这将使我们能够继续调查早期生活压力的影响。