Perinatal risk factors and genetic susceptibility for childhood psychopathology

儿童精神病理学的围产期危险因素和遗传易感性

基本信息

批准号：
7993148
负责人：
Yoko Nomura
金额：
$ 16.16万
依托单位：
QUEENS COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-18 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7993148
关键词：
Accounting Address Adult Age Amniocentesis Anxiety Anxiety Disorders Attention deficit hyperactivity disorder Behavior Behavioral Biological Birth Birth Weight Characteristics Child Child Development Childhood Chronic Clinical Clinical Research Cognitive Communities Data Data Analyses Data Collection Development Diagnostic Discipline Disease Disruptive Behavior Disorder Drops Educational process of instructing Emotional Enrollment Environment Epidemiologic Studies Etiology Exhibits Family Follow-Up Studies Fright Future Genetic Genetic Predisposition to Disease Goals Heritability Hyperactive behavior Impairment Incidence Infant Mortality Intervention Interview Investigation K-Series Research Career Programs Learning Length Life Cycle Stages Longitudinal Studies Low Birth Weight Infant Measures Medicine Mental Health Mental disorders Mentored Research Scientist Development Award Mentors Methods Modeling Monitor Morbidity - disease rate Mothers Neonatal Intensive Care Neonatal Intensive Care Units Neonatal Mortality New England Outcome Panic Disorder Pathway interactions Perinatal Perinatal Epidemiology Post-Traumatic Stress Disorders Pregnancy Pregnancy Outcome Premature Birth Problem behavior Psychiatry Psychopathology Public Health Recording of previous events Relative (related person)Reporting Research Research Infrastructure Research Personnel Research Training Risk Risk Factors Sampling Schools Scientist Social Phobia Societies Structure Survivors Technology Testing Training Training Activity Training Programs Ultrasonography Work base cohort cost depression design early childhood effective intervention epidemiological model experience fetal high school improved in utero inattention modifiable risk mortality multidisciplinary outcome forecast prenatal programs psychogenetics psychologic social

项目摘要

DESCRIPTION (provided by applicant): A notable recent advance in psychiatry is the recognition that mental health problems can originate in-utero. Research in developmental psychopathology has shown that preterm birth is associated with a 2- to 3-fold increased risk of both disruptive behavior and anxiety disorders. However, no prior studies have examined why preterm birth is associated with a wide range of childhood disorders. Furthermore, few studies have integrated models based on research in perinatal epidemiology and psychiatric genetics to understand the trajectory of developmental psychopathology. The purpose of this Mentored Research Scientist Development Award (K01) is to support the development of the candidate to become an independent scientist whose work will focus on the impact of modifiable prenatal predictors on mental illness, taking into account genetic influences. To achieve this goal, the candidate's multidisciplinary group of mentors will teach her specific methods for studying fetal/child development and psychiatric genetics, and guide her selection of coursework. For the candidate successfully integrate these disparate scientific disciplines, the team of mentors will actively monitor and review the candidate's progress. The research plan was significantly refined and simplified, and proposes a program of research comprised of two related studies: 1) a longitudinal epidemiologic study of 2,022 children who were enrolled in the National Collaborative Perinatal Study - New England and followed into adulthood and 2) a longitudinal study of 225 children at high and low risk for Attention Deficit Hyperactivity Disorder. Two competing hypotheses will be tested: (1) that different causes of preterm birth independently influence the risk of disruptive behavior and anxiety disorders; and (2) that preterm birth, regardless of its cause, interacts with genetic susceptibility to directly increase the risk for each disorder. In this revised application, genetic and epigenetic training at Jackson Lab is proposed in a place of the additional longitudinal statistics workshop. As a part of the training, the candidate will conduct retrospective data collection to gather supplemental information on the early developmental environment during pregnancy while maximizing the infrastructure available in the second study. This research has significant public health implications in helping to elucidate the developmental, biological, and genetic pathways through which childhood disorders develop. Subsequent identification of very early modifiable risk factors for childhood disorders will create new possibilities for earlier and more effective interventions. This may help relieve the burden in families with young children exhibiting psychopathology by informing new treatment approaches for young children. Together, this research and training program will effect the candidate's transition to independence as an investigator and will contribute greatly to our understanding of modifiable risk factors for disruptive behavior and anxiety disorders for planning and testing future interventions.

描述（由申请人提供）：精神病学的最新进展是，人们认识到心理健康问题可能起源于Utero。发育心理病理学的研究表明，早产与破坏性行为和焦虑症的风险增加了2至3倍。但是，没有先前的研究研究了为什么早产与多种儿童疾病有关。此外，很少有研究基于围产期流行病学和精神遗传学研究的研究模型，以了解发育心理病理学的轨迹。这项受过指导的研究科学家发展奖（K01）的目的是支持候选人成为独立科学家的发展，其工作将重点关注可修改的产前预测因素对精神疾病的影响，并考虑到遗传影响。为了实现这一目标，候选人的多学科导师小组将教她研究胎儿/儿童发育和精神遗传学的特定方法，并指导她选择课程工作。对于候选人成功整合了这些不同的科学学科，导师团队将积极监视和审查候选人的进步。该研究计划得到了大量完善和简化的研究，并提出了一项研究计划，包括两项相关研究：1）对2,022名儿童进行了纵向流行病学研究，这些儿童已入学，这是新英格兰的全国合作围产期研究 - 新英格兰并遵循了成年和225名在高风险中的纵向研究，并遵循225名儿童的纵向研究。将检验两个相互竞争的假设：（1）自早产的不同原因独立影响破坏性行为和焦虑症的风险；（2）早产，无论其原因如何，都与遗传敏感性相互作用，直接增加了每种疾病的风险。在此修订后的应用中，在杰克逊实验室的遗传和表观遗传训练中提出了其他纵向统计研讨会的位置。作为培训的一部分，候选人将进行回顾性数据收集，以收集有关怀孕期间早期发育环境的补充信息，同时最大程度地提高第二项研究中可用的基础设施。这项研究在帮助阐明儿童疾病发展的发展，生物学和遗传途径方面具有重要的公共卫生影响。随后确定儿童疾病的非常早期的可修改风险因素将为早期和更有效的干预措施创造新的可能性。这可能有助于通过为幼儿提供新的治疗方法来减轻有年幼的孩子表现出心理病理学的家庭的负担。这项研究和培训计划将影响候选人作为研究者的过渡到独立性的过渡，并将为我们对可修改的风险因素的理解做出很大的贡献，以实现颠覆性行为和焦虑症，以计划和测试未来的干预措施。