The Evolutionary Basis of the Developmental Course and Etiologies of Anxiety and Disruptive Behaviors during Early Adolescence

青春期早期焦虑和破坏性行为的发展过程和病因的进化基础

• 批准号: 10737103
• 负责人: Yoko Nomura
• 金额: $ 78.07万
• 依托单位: QUEENS COLLEGE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-17 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10737103
• 关键词: Acceleration; Adolescence; Adolescent; Age; Aggressive behavior; Amygdaloid structure; Anxiety; Area; Back; Behavior; Behavioral; Behavioral Symptoms; Biological; Birth; Brain; Buffers; COVID-19 pandemic; Child; Child Rearing; Childhood; Clinical; Cluster Analysis; Complement; Data Collection; Data Set; Development; Developmental Course; Diagnostic; Diffusion; Disease; Disruptive Behavior Disorder; Emotional; Environment; Etiology; Exposure to; Face; Family; Fright; Goals; Growth; Hair; Hippocampus; Individual; Individual Differences; Intervention; Interview; Life; Link; Measurable; Measures; Mediating; Mental Depression; Mental Health; Minority; Modeling; Mothers; Multimodal Imaging; National Institute of Mental Health; Natural Disasters; Natural experiment; Nature; Negative Valence; New York; Organ; Outcome; Participant; Phenotype; Population; Positioning Attribute; Pregnancy; Pregnant Women; Preparation; Protocols documentation; Psychopathology; Psychosocial Stress; Puberty; Quasi-experiment; Race; Random Allocation; Randomized; Regulation; Research Domain Criteria; Rest; Risk; Role; Sampling; Sex Differences; Signal Transduction; Source; Specimen; Stress; Structure; Surface; Symptoms; System; Testing; Thick; Time; United States National Institutes of Health; Work; behavior measurement; behavioral outcome; behavioral phenotyping; boys; childhood adversity; cognitive control; cohort; comorbidity; comparison control; coronavirus disease; early adolescence; early onset; fetal; fetal programming; follow up assessment; girls; gray matter; hazard; high risk; in utero; indexing; longitudinal analysis; low socioeconomic status; neural; neuroadaptation; neurobehavior; neurobehavioral; neuroimaging; neuromechanism; offspring; pandemic disease; pandemic impact; pandemic stress; postnatal; predictive modeling; preempt; prenatal; prenatal exposure; prenatal influence; prenatal stress; prospective; psychosocial; public health relevance; random forest; rate of change; recruit; repository; response; sex; sexual dimorphism; socioeconomics; stressor; substance use; symptomatology; white matter

Summary/Abstract: Accumulating evidence, including our own, indicates that in utero exposure to psychosocial stress is associated with risks for elevated anxiety (ANX) and disruptive behavior (DB) symptomatology. In this application, we will build on our existing birth cohort of children exposed and unexposed to Superstorm Sandy (SS) in utero. SS randomly “assigned” stressful conditions to pregnant women and their offspring in our cohort, giving us a unique opportunity to conduct a quasi-experiment of in utero stress. Using our deeply phenotyped cohort, we propose to investigate whether in utero SS exposure modulates the impact of the postnatal stressful environment, either amplifying (double-hit acceleration model) or shielding (stress inoculation model) the effects of postnatal stress on ANX and DB symptomatology. We will continue to measure different types of postnatal stress (normative, poor parenting, and COVID-related) to examine if magnitude, nature, timing and duration of the postnatal stressors influences the direction and impact on such symptomatology. As well as the DSM-based diagnostic outcomes, we will utilize the NIMH RDoC and focus on Negative Valence and Cognitive Control Systems (NVS/CCS), which will enable a transdiagnostic perspective of pre- and postnatal stress-related changes in behavior and the brain. Following our prior work, we will also examine sex-specific manifestations of the behavioral phenotypes (more internalizing problems in girls and more externalizing in boys) and explore the moderating role of SES when intersecting with individual differences in behaviors. As the brain is the central modulatory organ of stress/adaptation and regulation, we will use neuroimaging to assess changes in brain structure, function, and connectivity in limbic-frontal circuitry during early pre- and post-puberty, using a subsample of our cohort. Our cohort was followed from in utero, with completed follow-up assessments (neurobehavioral, clinical, and biological specimens), which will continue as they enter pre/puberty (ages 9-13), a time of peak risks for such problems and sex-dimorphism. Specifically, we will: 1) examine the effects of SS-related stress and the postnatal psychosocial environment on trajectories of clinical and adaptive neurobehaviors; 2) study the impact of prenatal SS stress and postnatal stress on NVS/CCS brain outcomes (structure and function) and evaluate the extent to which NVS/CCS structural changes mediate between prenatal SS-exposure and child anxiety and DB symptoms; and 3) develop predictive models for NVS/CCS outcomes in early adolescence based on biological and behavioral measures obtained in utero and/or the first decade of the child’s life. As pre/puberty is an important period of developmental transition and heightened risk for ANX and DB, we will build on our unique repository of both clinical and stored hair samples and continue to chart children’s neurobehavioral development and risk for psychopathology through ages 9-13. Together with the inclusion of neuroimaging to investigate neural mechanisms centered on the NVS/CCS and using tasks from the ABCD study, our study is uniquely positioned to elucidate the mechanisms of fetal programing and threat sensitivity in the NVS/SSV that modulate the risks for anxiety and reactive aggression.

摘要/摘要：累积证据，包括我们自己的证据，表明在子宫内暴露于社会心理 压力与动画升高（ANX）和破坏性行为（DB）症状的风险有关。在这个 应用，我们将建立在现有的出生队列中，暴露于Superstorm Sandy（SS） 在子宫里。 SS在我们的队列中为孕妇及其后代随机“分配”压力条件，给予 我们有一个独特的机会，可以在子宫压力中进行准经验。使用我们深厚的表型队列，我们 提议研究子宫内的暴露是否会调节产后压力环境的影响， 放大（双重加速模型）或屏蔽（应力接种模型）产后的影响 对ANX和DB症状的压力。我们将继续衡量不同类型的产后应力（规范性， 育儿不良，与共同相关），以检查产后应力源的大小，性质，时间和持续时间是否是 影响对这种症状的方向和影响。以及基于DSM的诊断结果，我们 将利用NIMH RDOC并专注于负价和认知控制系统（NVS/CC） 在行为和大脑的前后应力发生变化时，实现了经诊断的视角。 在先前的工作之后，我们还将研究行为表型的性别特定表现（更多 在女孩中内部化问题，男孩的外在化），并探讨SES的调节作用 与行为的个体差异相交。因为大脑是中心调节器官 压力/适应和调节，我们将使用神经影像来评估大脑结构，功能和 使用我们同类的子样本，在早期和木星前和puberty期间边缘额外电路中的连通性。我们的 从子宫内随后进行了队列，并完成了随访评估（神经行为，临床和生物学 标本），它将在进入前/青春期（9-13岁）时继续，这是此类问题的峰值风险和 性二态。特别是，我们将：1）检查与SS相关压力和产后心理社会的影响 关于临床和自适应神经行为轨迹的环境； 2）研究产前SS应力和 NVS/CCS脑结果（结构和功能）的产后应力（结构和功能），并评估NVS/CCS的程度 结构变化在产前SS暴露与儿童动画和DB符号之间介导； 3）发展 基于生物学和行为测量的早期青少年的NVS/CC结果的预测模型 在子宫和/或孩子一生的第一十年获得。因为预/青春期是发展的重要时期 过渡并增加了Anx和DB的风险，我们将建立在临床和存储的独特存储库的基础上 头发样本并继续绘制儿童的神经行为的发展和心理病理的风险 年龄9-13岁。再加上神经影像学以研究集中在以上的神经力学 NVS/CCS并使用ABCD研究的任务，我们的研究是独特的，以阐明 NVS/SSV中的胎儿编程和威胁敏感性调节动画和反应性侵略的风险。