Functional And Phenotypic Characterization Of T Cells In Man

人类 T 细胞的功能和表型特征

• 批准号: 7964822
• 负责人: Mario Roederer
• 金额: $ 34.79万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7964822
• 关键词: Acquired Immunodeficiency Syndrome; Adult; Antigens; Cells; Clinical; Complex; Cytotoxic T-Lymphocytes; Disease; Evaluation; HIV; HIV Infections; Health; Heterogeneity; Immune response; Immune system; Maintenance; Memory; Molecular Profiling; Pathogenesis; Role; T-Lymphocyte; T-Lymphocyte Subsets; Vaccines; Viral; Virus; chemokine receptor; cytokine; cytotoxic; man; response

The immune system in man is extremely complex, comprised of dozens of functionally-unique cell subsets. Each of these subsets may have a special role in the protection from viruses or other challenges to the immune system; only now are we beginning to recognize the extent of this heterogeneity and correlate the presence and functional state of these cells with clinical status of subjects. We have focused on four main topics within this broad subject: The expression of cytotoxic effector molecules; the expression profile of chemokine receptors; the functional evaluation of cytolytic T cells; and the detailed cytokine profile of antigen-specific T cells.

人类的免疫系统极其复杂，由数十个功能独特的细胞亚群组成。这些子集中的每一个都可能在保护免疫系统免受病毒或其他挑战方面发挥特殊作用；直到现在，我们才开始认识到这种异质性的程度，并将这些细胞的存在和功能状态与受试者的临床状态联系起来。我们重点关注这个广泛主题中的四个主要主题：细胞毒性效应分子的表达；趋化因子受体的表达谱；溶细胞T细胞的功能评估；以及抗原特异性 T 细胞的详细细胞因子谱。