Identification of HIV-specific B cells in blood

血液中 HIV 特异性 B 细胞的鉴定

• 批准号: 7184286
• 负责人: Mario Roederer
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7184286
• 关键词: AIDS vaccines; B lymphocyte; HIV infections; antibody formation; antiviral antibody; cell population study; epitope mapping; flow cytometry; human immunodeficiency virus; human tissue; leukocyte activation /transformation; vaccine evaluation; virus antigen

We are using sophisticated flow cytometric techniques to characterize, in detail, the B cell responses to HIV infection and to HIV vaccination. Our goal is to identify the antigen-specific B cells, isolate them, and then map the responses of the B cells to the viral proteins.

我们正在使用复杂的流式细胞仪技术来详细表征B细胞对HIV感染和HIV疫苗接种的反应。我们的目标是鉴定抗原特异性B细胞，将它们隔离，然后绘制B细胞对病毒蛋白的反应。