Investigating Obesity and Chronic Disease-Related Risk Factors of Alaska Natives

调查阿拉斯加原住民的肥胖和慢性病相关危险因素

• 批准号: 7848438
• 负责人: Gerald Mohatt
• 金额: $ 3.06万
• 依托单位: UNIVERSITY OF ALASKA FAIRBANKS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-08 至 2010-06-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7848438
• 关键词: Investigating; Obesity; Chronic; Disease; Related

DESCRIPTION (provided by applicant): The overall goal of the proposed COBRE-funded Center for Alaska Native Health Research (CANHR) is to achieve a permanent and sustainable research center at the University of Alaska Fairbanks (UAF) with the primary theme of investigating obesity and chronic disease-related risk, control, and prevention among Alaska Natives. Specific Aim 1. To enhance the biomedical research infrastructure for Alaska Native health research at the University of Alaska. This will be achieved through an increase in the University's commitment to biomedical research with Alaska Natives, additional research opportunities through an expansion of the number of Alaska Native research sites, formation of statewide research partnerships; and strengthening the integrated organizational structure for COBRE II research. Standing cores have been strengthened and functions consolidated; a Nutrition and Physical Activity Core has been added. The cores are aligned with the long-term CANHR research agenda. Specific Aim 2. Increase the number of investigators at the University of Alaska receiving NIH independent investigator funding for CANHR-related research. This will be achieved by completing four research projects by highly talented new CANHR investigators. Investigators are pursuing research that 1) develops a cultural understanding of the perceptions of weight and diabetes etiology and their relationships to health among Yup'ik Eskimos; 2) investigates a methodology of unbiased biomarkers of dietary intake based on variations in food stable isotope ratios and compares those biomarkers to concurrent diet records; 3) determines nutrients and contaminants in Yup'ik subsistence food sources; and 4) understands more precisely and measures stressors and coping methods among Yup'ik Eskimos. Each investigation will provide a more differentiated understanding of health disparities of Alaska Natives. They will serve as the basis for applications to NIH and a foundation for prevention, applied, and basic research into Alaska Native health disparities. CANHR will increase capacity and strengthen its mentorship ability by hiring two Associate Professors with a record of success in NIH funding. CANHR contributes to the public health of the Alaskan population by identifying risk and protective factors for chronic diseases among an underserved population. Results have implications for understanding the causes and contributing factors of health disparities of other rural minorities in America and in the circumpolar North. They have the potential for translation into additional research that will develop evidence-based practices for primary and secondary prevention. The COBRE provides a foundation for sustaining a research environment with a mission of utilizing research to influence policy and practices that can reduce health disparities.

描述（由申请人提供）：拟议的由阿拉斯加本地卫生研究中心（CANHR）提议的总体目标是在阿拉斯加大学费尔班克斯大学（UAF）实现一个永久且可持续的研究中心，其主要主题是研究肥胖和慢性疾病与疾病相关的风险，控制和预防阿拉斯加地区的疾病风险。具体目的1。为了增强阿拉斯加大学阿拉斯加本地健康研究的生物医学研究基础设施。这将通过增加大学与阿拉斯加本地人的生物医学研究的承诺，通过扩大阿拉斯加本地研究地点的数量，全州研究伙伴关系的形成来实现这一目标；并加强综合组织结构的COBRE II研究。站立核心已得到加强并功能合并；已经增加了营养和体育活动核心。核心与长期CANHR研究议程保持一致。具体目的2。增加阿拉斯加大学的调查人员数量，以接受NIH独立研究人员的研究资助CANHR相关研究。这将通过完成高才有才华的新CANHR调查人员完成四个研究项目来实现。研究人员正在追求研究，即1）对体重和糖尿病病因的看法及其与Yup'ik Eskimos的健康关系有一种文化理解； 2）研究了一种基于食物稳定同位素比的变化的饮食摄入量的无偏生物标志物的方法，并将这些生物标志物与并发饮食记录进行了比较； 3）确定Yup'ik生存食物来源中的营养和污染物； 4）更精确地了解Yup'ik Eskimos中的压力源和应对方法。每项调查都将为阿拉斯加原住民的健康差异提供更加不同的理解。他们将作为NIH申请的基础，并为阿拉斯加本地健康差异的预防，应用和基础研究的基础。 CANHR将通过在NIH资金中聘请两名副教授，从而提高能力并增强其指导能力。 CANHR通过确定服务不足人群中慢性疾病的风险和保护因素来为阿拉斯加人口的公共卫生做出贡献。结果对理解美国其他农村少数民族和北极北部少数民族的健康差异的原因和促成因素具有影响。他们有可能转化为其他研究，这些研究将开发基于证据的预防循证实践。该鞋底为维持研究环境的基础提供了利用研究来影响可以减少健康差异的政策和实践的使命。