Investigating the impact of physical activity in modulating PCOS risk among peripubertal females

调查体力活动对调节青春期前后女性 PCOS 风险的影响

• 批准号: 10591971
• 负责人: Rachel Whooten
• 金额: $ 19.42万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591971
• 关键词: Adolescence; Adolescent; Adult; Advisory Committees; Affect; Age; Androgens; Area; Attenuated; Behavior; Behavior Therapy; Behavioral; Biometry; Cardiovascular Diseases; Caregivers; Childhood; Chronic Disease; Clinical; Clinical Trials Design; Collection; Communities; Complex; Data; Development; Diabetes Mellitus; Dissemination and Implementation; Endocrine; Endocrine Physiology; Endocrinologist; Enrollment; Epidemiology; Female; Female Adolescents; Focus Groups; Functional disorder; Goals; Health; Health Care Costs; Health Services; Health behavior; Hormones; Hyperandrogenemia; Infertility; Insulin; Insulin Resistance; Intervention; Irregular Menstruation; K-Series Research Career Programs; Knowledge; Lead; Life Cycle Stages; Literature; Longitudinal cohort; Measurement; Measures; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentorship; Metabolic; Metabolic Diseases; Methods; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Obesity; Outcome; Phenotype; Physical activity; Physiological; Polycystic Ovary Syndrome; Prevention; Prevention strategy; Primary Prevention; Process; Public Health; Randomized; Reproductive Health; Research; Research Personnel; Research Priority; Risk; Series; Strenuous Exercise; Structure; Target Populations; Teenagers; Time; Training; Treatment Efficacy; Woman; Work; actigraphy; career; cohort; comorbidity; critical period; design; disorder prevention; early adolescence; effective intervention; efficacy trial; evidence base; exercise intervention; feasibility testing; follow-up; girls; implementation intervention; implementation science; improved; insight; insulin sensitivity; intervention participants; longitudinal analysis; metabolomics; multidisciplinary; obesity prevention; pilot trial; preventive intervention; reproductive; skills; therapy design; tool; young woman

PROJECT ABSTRACT Polycystic Ovary Syndrome (PCOS) affects 1 out of 10 women worldwide. While PCOS is primarily characterized by menstrual irregularity and hyperandrogenemia, it is also associated with multiple comorbidities – including diabetes, cardiovascular disease, depression, and infertility – that lead to substantial morbidity and health care costs. A complex interaction between adiposity, decreased insulin sensitivity, and increased androgen concentrations underlies the pathophysiology of PCOS. These signs often first appear in early adolescence, representing a key opportunity for preventive interventions. While physical activity is a promising strategy for targeting the factors underlying PCOS development, there is a significant literature gap regarding effective strategies for use in PCOS prevention. The goal of this proposal is to identify the time course of changes in insulin dynamics and androgen concentrations in females from mid-childhood through adolescence and the impact of physical activity during early adolescence on these endpoints (Aim 1) and use implementation science methods to refine (Aim 2) and pilot a targeted and evidence-based physical activity intervention in peripubertal girls ages 8-10 at risk for PCOS while assessing the interventions’ feasibility, acceptability, and preliminary efficacy in relation to physical activity levels, insulin sensitivity, and androgen concentrations (Aim 3). The findings from this study will inform the development, dissemination, and implementation of effective and scalable preventive interventions, a high priority area for the NIDDK. Additionally, by specifically targeting young females at risk for later metabolic disease, this proposal takes a life-course approach to chronic disease prevention. The PI, Dr. Whooten, is an early career clinician investigator and pediatric endocrinologist, as well as health services researcher. She will use this career development award to build her skills in (1) the longitudinal analysis of epidemiological cohorts, (2) design and implementation of behavioral interventions informed by an implementation science approach, and (3) collection and measurement of objective behavioral and physiologic outcomes which will be essential for evaluating intervention efficacy. Dr. Whooten will work closely with a multidisciplinary mentorship and advisory team with expertise in epidemiology, objective measurement of health behaviors, measurement of endocrine physiologic outcomes, implementation science, and biostatistics to carry out her stated career objectives and specific aims.

项目摘要 多囊卵巢综合征（PCOS）影响全球10名女性中的1个。而PCOS是 主要特征是月经不规则性和高雄激素血症，也是相关的 具有多种合并症 - 包括糖尿病，心血管疾病，抑郁症和 不孕症 - 导致大量发病率和医疗保健成本。复杂的相互作用 在肥胖，胰岛素敏感性降低和雄激素浓度升高之间 PCOS的病理生理基础。这些迹象通常首先出现在青春期早期 代表预防干预措施的关键机会。虽然身体活动是一个承诺 针对PCOS开发的因素的策略，有重要的文献 关于预防PCOS的有效策略的差距。该提议的目的是 确定女性胰岛素动力学和雄激素浓度变化的时间过程 从年龄中期到青少年，以及早期体育锻炼的影响 青少年在这些终点上（AIM 1）并使用实施科学方法来完善 （AIM 2）并在周围的有针对性的循证体育锻炼干预 8-10岁的女孩在评估干预措施的可行性，可接受性和 与身体活动水平，胰岛素敏感性和雄激素有关的初步效率 浓度（目标3）。这项研究的发现将为发展，传播， 以及实施有效且可扩展的预防干预措施，这是高优先级领域 niddk。另外，通过专门针对有后来代谢疾病风险的年轻女性， 该提案采取了慢性疾病预防的生活方式方法。 PI，Whooten博士， 是早期职业临床研究者和小儿内分泌学家，以及健康服务 研究员。她将使用这个职业发展奖来建立自己的技能 流行病学队列的分析，（2）行为干预的设计和实施 通过实施科学方法告知，（3）收集和测量 客观行为和生理结果，这对于评估干预至关重要 功效。 Whooten博士将与多学科的心态和咨询团队紧密合作 具有流行病学专业知识，对健康行为的客观测量，测量 内分泌生理结果，实施科学和生物统计学以执行她 陈述了职业目标和具体目标。